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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
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2000 1
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2003 6
2004 6
2005 9
2006 13
2007 11
2008 12
2009 11
2010 11
2011 5
2012 26
2013 35
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561 results

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Page 1
A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes.
Nguyen NUN, Canseco DC, Xiao F, Nakada Y, Li S, Lam NT, Muralidhar SA, Savla JJ, Hill JA, Le V, Zidan KA, El-Feky HW, Wang Z, Ahmed MS, Hubbi ME, Menendez-Montes I, Moon J, Ali SR, Le V, Villalobos E, Mohamed MS, Elhelaly WM, Thet S, Anene-Nzelu CG, Tan WLW, Foo RS, Meng X, Kanchwala M, Xing C, Roy J, Cyert MS, Rothermel BA, Sadek HA. Nguyen NUN, et al. Nature. 2020 Jun;582(7811):271-276. doi: 10.1038/s41586-020-2228-6. Epub 2020 Apr 22. Nature. 2020. PMID: 32499640 Free PMC article.
Chromatin immunoprecipitation with sequencing demonstrates that Meis1 and Hoxb13 act cooperatively to regulate cardiomyocyte maturation and cell cycle. Finally, we show that the calcium-activated protein phosphatase calcineurin dephosphorylates Hoxb13 at serine-204, …
Chromatin immunoprecipitation with sequencing demonstrates that Meis1 and Hoxb13 act cooperatively to regulate cardiomyocyte maturati …
HOXB13 in cancer development: molecular mechanisms and clinical implications.
Zhang J, Li YJ, Peng B, Yang X, Chen M, Li Y, Gao H, Li H, Zheng J. Zhang J, et al. Front Med. 2025 Jun;19(3):439-455. doi: 10.1007/s11684-024-1119-x. Epub 2025 Mar 11. Front Med. 2025. PMID: 40067581 Review.
The level of HOXB13 differs significantly between healthy and cancer tissues, which indicates that the level of HOXB13 is closely related to carcinogenesis. ...Moreover, HOXB13 variants play distinct roles in different cancers and populations. By understandin …
The level of HOXB13 differs significantly between healthy and cancer tissues, which indicates that the level of HOXB13 is clos …
Hoxb13, a potential prognostic biomarker for prostate cancer.
Ouhtit A, Al-Kindi MN, Kumar PR, Gupta I, Shanmuganathan S, Tamimi Y. Ouhtit A, et al. Front Biosci (Elite Ed). 2016 Jan 1;8(1):40-5. doi: 10.2741/E749. Front Biosci (Elite Ed). 2016. PMID: 26709644 Free article. Review.
HOXB13, a member of the homeobox proteins family, is a key regulator of the epithelial differentiation in the prostate gland. ...In this report, we review the functions attributed to HOXB13, by highlighting the most recent findings supporting the hypothesis that …
HOXB13, a member of the homeobox proteins family, is a key regulator of the epithelial differentiation in the prostate gland. ...In t …
HOXB13 controls cell state through super-enhancers.
Aspuria PJ, Cheon DJ, Gozo MC, Beach JA, Recouvreux MS, Walts AE, Karlan BY, Orsulic S. Aspuria PJ, et al. Exp Cell Res. 2020 Aug 1;393(1):112039. doi: 10.1016/j.yexcr.2020.112039. Epub 2020 May 4. Exp Cell Res. 2020. PMID: 32376288 Free article.
In a xenograft model of rhabdoid tumor, knockout of HOXB13 diminished tumor growth while partial knockdown of HOXB13 promoted differentiation of tumor cells into bone. These results suggest that HOXB13 enhances rhabdoid malignancy by interfering with mesenchy …
In a xenograft model of rhabdoid tumor, knockout of HOXB13 diminished tumor growth while partial knockdown of HOXB13 promoted …
Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer.
Patel RA, Sayar E, Coleman I, Roudier MP, Hanratty B, Low JY, Jaiswal N, Ajkunic A, Dumpit R, Ercan C, Salama N, O'Brien VP, Isaacs WB, Epstein JI, De Marzo AM, Trock BJ, Luo J, Brennen WN, Tretiakova M, Vakar-Lopez F, True LD, Goodrich DW, Corey E, Morrissey C, Nelson PS, Hurley PJ, Gulati R, Haffner MC. Patel RA, et al. J Pathol. 2024 Jan;262(1):105-120. doi: 10.1002/path.6216. Epub 2023 Oct 18. J Pathol. 2024. PMID: 37850574 Free PMC article.
We observed that HOXB13 expression increases during later stages of murine prostate development. All localized prostate cancers showed HOXB13 protein expression. Interestingly, lower HOXB13 expression levels were observed in higher-grade tumors, although no s …
We observed that HOXB13 expression increases during later stages of murine prostate development. All localized prostate cancers showe …
Association of HOXB13 G84E With Prostate Cancer Among 592,158 Men.
Crawford TB, Nelson T, Karunamuni R, Desai H, Hausler R, Teerlink C, Carter H, Pagadala MS, Alba PR, DuVall SL, Danowski ME, Brunette CA, Ratner D, Garraway IP, Rose BS, Smith JR, Cooney KA, Vassy JL, Hauger RL, Lynch JA, Seibert TM, Maxwell KN. Crawford TB, et al. J Natl Compr Canc Netw. 2025 Sep 15;23(10):e257055. doi: 10.6004/jnccn.2025.7055. J Natl Compr Canc Netw. 2025. PMID: 40953603
CONCLUSIONS: In the largest cohort of men with the HOXB13 p.G84E variant studied to date, we demonstrate a moderately increased lifetime risk of PrCa. ...Further research is warranted to determine whether early PrCa screening in HOXB13 p.G84E heterozygotes improves …
CONCLUSIONS: In the largest cohort of men with the HOXB13 p.G84E variant studied to date, we demonstrate a moderately increased lifet …
HOXB13-Mediated Lipid Metabolism Regulates Prostate Cancer Metastasis.
Xiong J. Xiong J. Serican J Med. 2024 Dec;1(1):23157. doi: 10.17161/sjm.v1i1.23157. Serican J Med. 2024. PMID: 42146319 Free PMC article.
Their study demonstrates how HOXB13 modulates PCa metastasis through epigenetic reprogramming, specifically by interacting with histone deacetylase 3 (HDAC3). These findings not only deepen our understanding of the molecular processes underlying PCa metastasis but also sug …
Their study demonstrates how HOXB13 modulates PCa metastasis through epigenetic reprogramming, specifically by interacting with histo …
Distinct transcription factor interactions drive HOXB13 activity in different stages of prostate cancer.
Ersoy-Fazlioglu B, Lingadahalli S, Altintas UB, Cingoz A, Tekoglu E, Lok Yu IP, Dikbas M, Missaghimamaghani O, Yavuz K, Adomat H, Kulac I, Morova T, Xiao K, Gleave M, Fazli L, Cejas P, Cherkasov A, Zwart W, Haffner MC, Long HW, Collins C, Bagci-Onder T, Lack NA. Ersoy-Fazlioglu B, et al. Proc Natl Acad Sci U S A. 2025 Dec 9;122(49):e2500327122. doi: 10.1073/pnas.2500327122. Epub 2025 Dec 4. Proc Natl Acad Sci U S A. 2025. PMID: 41343677 Free PMC article.
Strikingly, HOXB13 is remarkably selective and has almost no effect on nonprostatic tissues. Despite this common essentiality in PCa, HOXB13 activity is markedly different in AR-negative stem cell-like tumors, where interactions with the AP-1 change the HOXB13 …
Strikingly, HOXB13 is remarkably selective and has almost no effect on nonprostatic tissues. Despite this common essentiality in PCa, …
HOXB13 facilitates hepatocellular carcinoma progression by activating AKT/mTOR signaling pathway.
Li M, Tan T, Geng Y, Tao Y, Pan J, Zhang J, Xu Q, Shen H, Zuo L, Chen Y. Li M, et al. Ann Hepatol. 2023 Jan-Feb;28(1):100759. doi: 10.1016/j.aohep.2022.100759. Epub 2022 Sep 28. Ann Hepatol. 2023. PMID: 36179794 Free article.
Western blot assay was applied to analyze the effect of HOXB13 on related signaling pathways. In addition, the role of HOXB13 on HCC in vivo was explored using a HCC mouse model. ...HOXB13 may be a novel target for HCC therapy....
Western blot assay was applied to analyze the effect of HOXB13 on related signaling pathways. In addition, the role of HOXB13 …
ACK1-AR and AR-HOXB13 signaling axes: epigenetic regulation of lethal prostate cancers.
Kim EH, Cao D, Mahajan NP, Andriole GL, Mahajan K. Kim EH, et al. NAR Cancer. 2020 Aug 27;2(3):zcaa018. doi: 10.1093/narcan/zcaa018. eCollection 2020 Sep. NAR Cancer. 2020. PMID: 32885168 Free PMC article. Review.
CRPCs also deploy the bromodomain and extra-terminal domain protein BRD4 to epigenetically increase HOXB13 gene expression, which in turn activates the MYC target genes AURKA/AURKB. HOXB13 also facilitates ligand-independent recruitment of the AR splice variant AR-V …
CRPCs also deploy the bromodomain and extra-terminal domain protein BRD4 to epigenetically increase HOXB13 gene expression, which in …
561 results