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hoxc12/c13 as key regulators for rebooting the developmental program in Xenopus limb regeneration.
Kawasumi-Kita A, Lee SW, Ohtsuka D, Niimi K, Asakura Y, Kitajima K, Sakane Y, Tamura K, Ochi H, Suzuki KT, Morishita Y. Kawasumi-Kita A, et al. Nat Commun. 2024 Apr 22;15(1):3340. doi: 10.1038/s41467-024-47093-y. Nat Commun. 2024. PMID: 38649703 Free PMC article.
Transcriptomic analysis of larval limb blastema reveals that hoxc12/c13 show the highest regeneration specificity in expression. Knocking out each of them through genome editing inhibits cell proliferation and expression of a group of genes that are essential for developme …
Transcriptomic analysis of larval limb blastema reveals that hoxc12/c13 show the highest regeneration specificity in expression. Knoc …
HOXC12 promotes the invasion and migration of gastric cancer cells by upregulating SALL4 and activating Wnt/beta-catenin signaling pathway.
Zhang J, Hou N, Rao D, Chen Q, Ning Z, Lu M. Zhang J, et al. Discov Oncol. 2024 Nov 5;15(1):620. doi: 10.1007/s12672-024-01502-2. Discov Oncol. 2024. PMID: 39500780 Free PMC article.
However, the relationship between Homeobox C12 (HOXC12) and gastric cancer is still unclear. METHODS: TCGA-STAD and HPA data were analyzed to explore HOXC12 level. ...HOXC12 upregulated the transcription of SALL4 by binding to its promoter. HOXC12 was …
However, the relationship between Homeobox C12 (HOXC12) and gastric cancer is still unclear. METHODS: TCGA-STAD and HPA data were ana …
Hoxc12 expression pattern in developing and cycling murine hair follicles.
Shang L, Pruett ND, Awgulewitsch A. Shang L, et al. Mech Dev. 2002 May;113(2):207-10. doi: 10.1016/s0925-4773(02)00022-9. Mech Dev. 2002. PMID: 11960714 Free article.
We examine the Hoxc12 RNA expression pattern during both hair follicle morphogenesis and cycling in direct comparison to its only upstream neighbor, Hoxc13. ...During the progressive growth phase (anagen) of developing and cycling follicles, the distinct proximo-distal exp …
We examine the Hoxc12 RNA expression pattern during both hair follicle morphogenesis and cycling in direct comparison to its only ups …
Hox-C12 coordinates β2-adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer.
Lam T, Cardwell B, Liu B, Peng C, Spark M, Sursock S, Nowell CJ, Ellisdon AM, Chang A, Keen AC, Sloan EK, Halls ML. Lam T, et al. Sci Signal. 2025 Aug 19;18(900):eadq8279. doi: 10.1126/scisignal.adq8279. Epub 2025 Aug 19. Sci Signal. 2025. PMID: 40828908
Knocking out HOXC12 prevented beta(2)-adrenoceptor-mediated calcium signaling and invasion in cultured TNBC cells. In basal breast cancers, HOXC12 expression in tumors negatively correlated with overall and disease-free survival in patients. ...
Knocking out HOXC12 prevented beta(2)-adrenoceptor-mediated calcium signaling and invasion in cultured TNBC cells. In basal breast ca …
Genetic and Epigenetic Regulation of the Innate Immune Response to Gout.
de Lima JD, de Paula AGP, Yuasa BS, de Souza Smanioto CC, da Cruz Silva MC, Dos Santos PI, Prado KB, Winter Boldt AB, Braga TT. de Lima JD, et al. Immunol Invest. 2023 Apr;52(3):364-397. doi: 10.1080/08820139.2023.2168554. Epub 2023 Feb 6. Immunol Invest. 2023. PMID: 36745138 Review.
Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast canc …
Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomat …
Akt1 mediates the posterior Hoxc gene expression through epigenetic modifications in mouse embryonic fibroblasts.
Kong KA, Lee JY, Oh JH, Lee Y, Kim MH. Kong KA, et al. Biochim Biophys Acta. 2014 Sep;1839(9):793-9. doi: 10.1016/j.bbagrm.2014.06.011. Epub 2014 Jun 21. Biochim Biophys Acta. 2014. PMID: 24955524
A knockdown study revealed that Hdac6 is mediated in the Hoxc12 repression through direct binding to the transcription start site (TSS) in the presence of Akt1. ...Furthermore, exogenous Akt1 was enriched at the promoter region of the posterior Hoxc genes such as Hoxc11 an …
A knockdown study revealed that Hdac6 is mediated in the Hoxc12 repression through direct binding to the transcription start site (TS …
HOTAIR as a diagnostic and prognostic biomarker of gastrointestinal cancers: an updated meta-analysis and bioinformatics analysis based on TCGA data.
Yang J, Xu S, Wang S, Zou X, Duan M, Zhang Q, Wang C. Yang J, et al. Biosci Rep. 2023 Mar 31;43(3):BSR20222174. doi: 10.1042/BSR20222174. Biosci Rep. 2023. PMID: 36924407 Free PMC article.
The high correlation between the expression of homeobox C (HOXC) family genes and HOTAIR, with correlation coefficients of 0.863 (HOXC11), 0.664 (HOXC10), 0.645 (HOXC8), and 0.581 (HOXC12). The 'cell cycle' pathway and pathways relating to infections, namely 'herpes simple …
The high correlation between the expression of homeobox C (HOXC) family genes and HOTAIR, with correlation coefficients of 0.863 (HOXC11), 0 …
Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients.
Shahbaz S, Rezaeifar M, Syed H, Redmond D, Terveart JWC, Osman M, Elahi S. Shahbaz S, et al. Brain Behav Immun. 2025 Feb;124:97-114. doi: 10.1016/j.bbi.2024.11.032. Epub 2024 Nov 29. Brain Behav Immun. 2025. PMID: 39615603 Free article.
Key findings include the upregulation of genes involved in immune dysregulation and neuronal development, such as Fezf2, BRINP2, HOXC12, MEIS2, ZFHX3, and RELN. These genes are linked to neuroinflammatory responses, cognitive impairments, and hematopoietic disturbances, su …
Key findings include the upregulation of genes involved in immune dysregulation and neuronal development, such as Fezf2, BRINP2, HOXC12 …
HOXC4 Is Associated with the Prognosis and Immune Cell Infiltration in the Progression of Prostate Cancer.
Chen Z, Wang D, Xie Y, Fang Z, Wang J, Yu Z, Chen Z, Zou Y, Chen Z, Liu Q, Huang H. Chen Z, et al. Curr Gene Ther. 2026 May 20. doi: 10.2174/0115665232480070260518114905. Online ahead of print. Curr Gene Ther. 2026. PMID: 42227542
RESULTS: Upregulated expressions of HOXC4, HOXC5, HOXC12, and HOXC13 in PCa tissues were found to be correlated with a worse prognosis. A prognostic model incorporating HOXC4 expression level, T stage, and Gleason score was constructed, exhibiting excellent performance in …
RESULTS: Upregulated expressions of HOXC4, HOXC5, HOXC12, and HOXC13 in PCa tissues were found to be correlated with a worse prognosi …
33 results