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77 results

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Page 1
Downregulation of HS6ST2 Inhibits Cervical Cancer Cell Migration and Invasion in Vivo and in Vitro.
Li S, Shen H, Wan Q, Chen P, Shu C, Wang H, Zhu W. Li S, et al. Discov Med. 2023 Dec;35(179):1147-1159. doi: 10.24976/Discov.Med.202335179.111. Discov Med. 2023. PMID: 38058080 Free article.
The impact of HS6ST2 knockdown in CC proliferation was also evaluated in vivo using a nude mice model. ...Fluorescent quantitative PCR and immunohistochemistry experiments identified HS6ST2 as highly upregulated within patients CC tissues. Survival analysis taking i …
The impact of HS6ST2 knockdown in CC proliferation was also evaluated in vivo using a nude mice model. ...Fluorescent quantitative PC …
Pan-cancer analysis of HS6ST2: associations with prognosis, tumor immunity, and drug resistance.
Huang L, Irshad S, Sultana U, Ali S, Jamil A, Zubair A, Sultan R, Abdel-Maksoud MA, Mubarak A, Almunqedhi BM, Almanaa TN, Malik A, Alamri A, Kodous AS, Mares M, Zaky MY, Saba Sajjad S, Hameed Y. Huang L, et al. Am J Transl Res. 2024 Mar 15;16(3):873-888. doi: 10.62347/NCPH5416. eCollection 2024. Am J Transl Res. 2024. PMID: 38586106 Free PMC article.
Moreover, HS6ST2 expression correlated with pathological stages in CESC, KICH, LUAD, and STAD patients. ...Single-cell functional states analysis demonstrated associations between HS6ST2 and diverse cellular processes. Moreover, gene enrichment analysis revealed the …
Moreover, HS6ST2 expression correlated with pathological stages in CESC, KICH, LUAD, and STAD patients. ...Single-cell functional sta …
A HS6ST2 gene variant associated with X-linked intellectual disability and severe myopia in two male twins.
Paganini L, Hadi LA, Chetta M, Rovina D, Fontana L, Colapietro P, Bonaparte E, Pezzani L, Marchisio P, Tabano SM, Costanza J, Sirchia SM, Riboni L, Milani D, Miozzo M. Paganini L, et al. Clin Genet. 2019 Mar;95(3):368-374. doi: 10.1111/cge.13485. Epub 2018 Dec 26. Clin Genet. 2019. PMID: 30471091 Free PMC article.
WES analysis detected the novel, maternally inherited, mutation c.916G > C (G306R) in the X-linked heparan sulfate 6-O-sulfotransferase 2 (HS6ST2) gene. HS6ST2 transfers sulfate from adenosine 3'-phosphate, 5'-phosphosulfate to the sixth position of the N-sulphog …
WES analysis detected the novel, maternally inherited, mutation c.916G > C (G306R) in the X-linked heparan sulfate 6-O-sulfotransferase 2 …
Pancancer analysis of the correlations of HS6ST2 with prognosis, tumor immunity, and drug resistance.
Chen W, Li X, Jiang Y, Ni D, Yang L, Wu J, Gao M, Wang J, Song J, Shi W. Chen W, et al. Sci Rep. 2023 Nov 6;13(1):19209. doi: 10.1038/s41598-023-46525-x. Sci Rep. 2023. PMID: 37932473 Free PMC article.
Although mounting evidence supports a vital role for HS6ST2 in tumorigenesis of some cancers, no pan-cancer analysis of HS6ST2 has been reported. ...Eventually, HS6ST2 was validated in human lung adenocarcinoma tissues. Our study reveals that HS6ST2 ca …
Although mounting evidence supports a vital role for HS6ST2 in tumorigenesis of some cancers, no pan-cancer analysis of HS6ST2 …
Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis.
Guo Y, Min Z, Jiang C, Wang W, Yan J, Xu P, Xu K, Xu J, Sun M, Zhao Y, Hussain S, Zhang R, Wang Q, Han Y, Zhang F, Zhu W, Li D, Meng L, Sun J, Lu S. Guo Y, et al. Cell Death Dis. 2018 Jun 13;9(6):699. doi: 10.1038/s41419-018-0729-0. Cell Death Dis. 2018. PMID: 29899528 Free PMC article.
In this study, we demonstrated that the expression of HS6ST2 was lower in OA-damaged cartilage than smooth cartilage from the same patient. In chondrocytes, HS6ST2 could be targeted by miR-23b-3p, which was higher expressed in OA-damaged cartilage. Under TNF-alpha s …
In this study, we demonstrated that the expression of HS6ST2 was lower in OA-damaged cartilage than smooth cartilage from the same pa …
Knockout of the intellectual disability-linked gene Hs6st2 in mice decreases heparan sulfate 6-O-sulfation, impairs dendritic spines of hippocampal neurons, and affects memory.
Moon S, Lee HH, Archer-Hartmann S, Nagai N, Mubasher Z, Parappurath M, Ahmed L, Ramos RL, Kimata K, Azadi P, Cai W, Zhao JY. Moon S, et al. Glycobiology. 2024 Mar 26;34(2):cwad095. doi: 10.1093/glycob/cwad095. Glycobiology. 2024. PMID: 38015989 Free PMC article.
To determine the role of Hs6st2 in the brain, we carried out a series of molecular and behavioral assessments on Hs6st2 knockout mice. ...Taken together, our study provides novel molecular and behavioral insights into the role of Hs6st2 in the brain, which fa …
To determine the role of Hs6st2 in the brain, we carried out a series of molecular and behavioral assessments on Hs6st2 knocko …
Heparan sulfate 6-O-sulfotransferase 2 promotes gastric cancer progression by modulating the TGF-β/smad2/3 pathway.
Wu S, Xu C, Sun W, Xu Q, Zhou F, Jia R, Xu H. Wu S, et al. Am J Transl Res. 2024 Dec 15;16(12):7924-7936. doi: 10.62347/LWZR1836. eCollection 2024. Am J Transl Res. 2024. PMID: 39822499 Free PMC article.
The correlation between the expression level of HS6ST2 and clinicopathological parameters were observed. The protein expression of HS6ST2 in AGS, MKN45 and GES-1 cells was examined using Western blotting. ...Compared with GES-1 cells, the expression level of HS6S …
The correlation between the expression level of HS6ST2 and clinicopathological parameters were observed. The protein expression of …
A novel missense variant of HS6ST2 gene in Paganini-Miozzo syndrome with a rare neurodevelopmental and Endocrine phenotypes.
Zhang M, Chang X, Du X, Chen Z, Zhang X, Cai F. Zhang M, et al. Front Genet. 2025 Jul 4;16:1515260. doi: 10.3389/fgene.2025.1515260. eCollection 2025. Front Genet. 2025. PMID: 40686562 Free PMC article.
Paganini-Miozzo syndrome (MRXSPM) is a globally rare disease caused by hemizygous mutations in the HS6ST2 gene on chromosome Xq26. This study presents the first case of MRXSPM in China, meanwhile the fourth case worldwide. ...In vitro cell experiments demonstrated that thi …
Paganini-Miozzo syndrome (MRXSPM) is a globally rare disease caused by hemizygous mutations in the HS6ST2 gene on chromosome Xq26. Th …
Overexpression of HS6ST2 is associated with poor prognosis in patients with gastric cancer.
Jin Y, He J, Du J, Zhang RX, Yao HB, Shao QS. Jin Y, et al. Oncol Lett. 2017 Nov;14(5):6191-6197. doi: 10.3892/ol.2017.6944. Epub 2017 Sep 14. Oncol Lett. 2017. PMID: 29113266 Free PMC article.
Survival analysis revealed an association between patients with increased expression of HS6ST2 and a poor prognosis of gastric cancer. Cox regression analysis indicated that the expression of HS6ST2 was an independent negative prognostic factor for GC. The expressio …
Survival analysis revealed an association between patients with increased expression of HS6ST2 and a poor prognosis of gastric cancer …
Role of lncRNA FAM83H antisense RNA1 (FAM83H-AS1) in the progression of non-small cell lung cancer by regulating the miR-545-3p/heparan sulfate 6-O-sulfotransferase (HS6ST2) axis.
Zhang Y, Yu Y, Cao X, Chen P. Zhang Y, et al. Bioengineered. 2022 Mar;13(3):6476-6489. doi: 10.1080/21655979.2022.2031668. Bioengineered. 2022. PMID: 35260044 Free PMC article.
Simultaneously, miR-545-3p negatively regulates heparan sulfate 6-O-sulfotransferase (HS6ST2). Moreover, inhibition of miR-545-3p promoted HS6ST2 protein expression and lung cancer cell invasion. FAM83H-AS1 favors non-small cell lung cancer by targeting the miR-545- …
Simultaneously, miR-545-3p negatively regulates heparan sulfate 6-O-sulfotransferase (HS6ST2). Moreover, inhibition of miR-545-3p pro …
77 results