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1,352 results

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Page 1
HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.
Stricher F, Macri C, Ruff M, Muller S. Stricher F, et al. Autophagy. 2013 Dec;9(12):1937-54. doi: 10.4161/auto.26448. Epub 2013 Oct 8. Autophagy. 2013. PMID: 24121476 Free article. Review.
HSPA8/HSC70 protein is a fascinating chaperone protein. It represents a constitutively expressed, cognate protein of the HSP70 family, which is central in many cellular processes. ...
HSPA8/HSC70 protein is a fascinating chaperone protein. It represents a constitutively expressed, cognate protein of the HSP70 family …
HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation.
Wu E, He W, Wu C, Chen Z, Zhou S, Wu X, Hu Z, Jia K, Pan J, Wang L, Qin J, Liu D, Lu J, Wang H, Li J, Wang S, Sun L. Wu E, et al. Cell Res. 2023 Nov;33(11):851-866. doi: 10.1038/s41422-023-00859-3. Epub 2023 Aug 14. Cell Res. 2023. PMID: 37580406 Free PMC article.
The SBD domain of HSPA8 interacts with RHIM-containing proteins, preventing proximate RHIM monomers from stacking into functional fibrils; furthermore, with the NBD domain supplying energy via ATP hydrolysis, HSPA8 breaks down pre-formed RHIM-amyloids into non-funct …
The SBD domain of HSPA8 interacts with RHIM-containing proteins, preventing proximate RHIM monomers from stacking into functional fib …
HBx-Induced HSPA8 Stimulates HBV Replication and Suppresses Ferroptosis to Support Liver Cancer Progression.
Wang Y, Zhao M, Zhao L, Geng Y, Li G, Chen L, Yu J, Yuan H, Zhang H, Yun H, Yuan Y, Wang G, Feng J, Xu L, Wang S, Hou C, Yang G, Zhang N, Lu W, Zhang X. Wang Y, et al. Cancer Res. 2023 Apr 4;83(7):1048-1061. doi: 10.1158/0008-5472.CAN-22-3169. Cancer Res. 2023. PMID: 36745032
In conclusion, HBx-elevated HSPA8 regulates both HBV replication and ferroptosis in liver cancer. Targeting HSPA8 could be a promising strategy for controlling HBV and hepatocarcinogenesis. SIGNIFICANCE: HBV-induced upregulation of HSPA8 promotes hepatocarcin …
In conclusion, HBx-elevated HSPA8 regulates both HBV replication and ferroptosis in liver cancer. Targeting HSPA8 could be a p …
HSPA8 Activates Wnt/beta-Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA-Mediated CAV1 Degradation.
Li B, Ming H, Qin S, Zhou L, Huang Z, Jin P, Peng L, Luo M, Zhang T, Wang K, Liu R, Liou YC, Nice EC, Jiang J, Huang C. Li B, et al. Adv Sci (Weinh). 2024 Jan;11(3):e2306535. doi: 10.1002/advs.202306535. Epub 2023 Nov 16. Adv Sci (Weinh). 2024. PMID: 37973552 Free PMC article.
Furthermore, pharmacological targeting HSPA8 by VER155008 exhibits synergistic effects with BRAF inhibitors on CRC mouse models. In summary, these findings discover the important role of the HSPA8/CAV1/beta-catenin axis in the development of refractory BRAF V600E CR …
Furthermore, pharmacological targeting HSPA8 by VER155008 exhibits synergistic effects with BRAF inhibitors on CRC mouse models. In s …
RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination.
Zhang C, Wang Y, Wu G, Sun N, Bai H, Li X, Han S, Zhou H, Qi R, Zhang J. Zhang C, et al. Biol Direct. 2024 Feb 23;19(1):16. doi: 10.1186/s13062-024-00453-6. Biol Direct. 2024. PMID: 38395908 Free PMC article.
RPL35A knockdown inhibited the proliferation and migration of HCCC-9810 and HUCCT1 cells, induced apoptosis, and arrested the cell cycle in G1 phase. HSPA8 was a downstream protein of RPL35A and overexpressed in CCA. RPL35A knockdown impaired HSPA8 protein stability …
RPL35A knockdown inhibited the proliferation and migration of HCCC-9810 and HUCCT1 cells, induced apoptosis, and arrested the cell cycle in …
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation.
Yang G, Ma C, Chen Y, Xiang J, Li L, Li Y, Kang L, Liang Z, Yang S. Yang G, et al. Cell Rep. 2025 Mar 25;44(3):115339. doi: 10.1016/j.celrep.2025.115339. Epub 2025 Feb 19. Cell Rep. 2025. PMID: 39977267 Free article.
TEC-specific overexpression of HSPA8 restrains these changes. INSIG1/2 can be phosphorylated by protein kinase R (PKR), while HSPA8 recognizes PKR and recruits the E3 ubiquitin ligase to promote PKR ubiquitination and degradation. Under temporary hyperglycemic stimu …
TEC-specific overexpression of HSPA8 restrains these changes. INSIG1/2 can be phosphorylated by protein kinase R (PKR), while HSPA …
HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates.
Bonam SR, Ruff M, Muller S. Bonam SR, et al. Cells. 2019 Aug 7;8(8):849. doi: 10.3390/cells8080849. Cells. 2019. PMID: 31394830 Free PMC article. Review.
HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. ...We also exemplify the interest of targeting HSPA8 to regulate pathological immune dysfunctions....
HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. ...We also exemplify the interest of targeting …
Pristimerin Promotes Ubiquitination of HSPA8 and Activates the VAV1/ERK Pathway to Suppress TNBC Proliferation.
Liu QW, Fan QL, Chen JY, Liu JX, Li Y, Luo Q, Chen YP, Wu HT, Xu AQ, Wang S, Lu AP, Guan DG. Liu QW, et al. Adv Sci (Weinh). 2025 Mar;12(10):e2413174. doi: 10.1002/advs.202413174. Epub 2025 Jan 15. Adv Sci (Weinh). 2025. PMID: 39813169 Free PMC article.
The further results suggested that pristimerin promoted the ubiquitination and degradation of HSPA8, leading to a decrease in the degradation of Vac Guanine Nucleotide Exchange Factor 1 (VAV1), a downstream client protein of HSPA8 which plays a crucial role in activ …
The further results suggested that pristimerin promoted the ubiquitination and degradation of HSPA8, leading to a decrease in the deg …
Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression.
Deng W, Ai J, Zhang W, Zhou Z, Li M, Yan L, Zhang L, Huang Z, Wu Z, Ai J, Jiang H. Deng W, et al. J Transl Med. 2023 Sep 15;21(1):625. doi: 10.1186/s12967-023-04408-9. J Transl Med. 2023. PMID: 37715221 Free PMC article.
PRMT9 suppressed ferroptosis to accelerate HCC progression in vivo. PRMT9 targeted HSPA8 and enhanced arginine methylation of HSPA8 at R76 and R100 to regulate ferroptosis in HCC. ...HSPA8 overexpression up-regulated CD44 expression and knockdown of CD44 sign …
PRMT9 suppressed ferroptosis to accelerate HCC progression in vivo. PRMT9 targeted HSPA8 and enhanced arginine methylation of HSPA …
BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly.
Gan S, Zhou S, Ma J, Xiong M, Xiong W, Fan X, Liu K, Gui Y, Chen B, Zhang B, Wang X, Wang F, Li Z, Yan W, Ma M, Yuan S. Gan S, et al. EMBO Rep. 2024 Apr;25(4):2045-2070. doi: 10.1038/s44319-024-00112-x. Epub 2024 Mar 7. EMBO Rep. 2024. PMID: 38454159 Free PMC article.
Mechanistically, we find that BAG5 forms a complex with HSPA8 and promotes the folding of SPATA6 by enhancing HSPA8's affinity for substrate proteins. Collectively, our findings reveal a novel protein-regulated network in sperm formation in which BAG5 governs the as …
Mechanistically, we find that BAG5 forms a complex with HSPA8 and promotes the folding of SPATA6 by enhancing HSPA8's affinity …
1,352 results