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Year Number of Results
2004 1
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Page 1
HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death.
Wenta T, Rychlowski M, Jarzab M, Lipinska B. Wenta T, et al. Cells. 2019 Sep 20;8(10):1112. doi: 10.3390/cells8101112. Cells. 2019. PMID: 31546993 Free PMC article.
The HtrA4 human protease is crucial in placentation and embryo implantation, and its altered level is connected with pre-eclampsia. ...The effect is dependent on the HtrA4 proteolytic activity, and the N-terminally deleted HtrA4 is more efficient in the cell …
The HtrA4 human protease is crucial in placentation and embryo implantation, and its altered level is connected with pre-eclampsia. . …
Deficiency of HtrA4 in BeWo cells downregulates angiogenesis through IL-6/JAK/STAT3 signaling.
Pei CZ, Seok J, Kim GJ, Choi BC, Baek KH. Pei CZ, et al. Biomed Pharmacother. 2023 Oct;166:115288. doi: 10.1016/j.biopha.2023.115288. Epub 2023 Aug 12. Biomed Pharmacother. 2023. PMID: 37579694 Free article.
To explore the role of HtrA4 in angiogenesis, HUVECs were co-cultured with wild-type BeWo cells (BeWo WT), BeWo KO, and HtrA4-rescued BeWo KO (BeWo KO-HtrA4 rescue) cells. ...HtrA4 deficiency in trophoblasts hinders angiogenesis and may contribute to p …
To explore the role of HtrA4 in angiogenesis, HUVECs were co-cultured with wild-type BeWo cells (BeWo WT), BeWo KO, and HtrA4- …
Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes.
Wang Y, Lim R, Nie G. Wang Y, et al. Placenta. 2020 Jan 15;90:71-81. doi: 10.1016/j.placenta.2019.12.012. Epub 2019 Dec 14. Placenta. 2020. PMID: 32056555
The results were then validated by RT-PCR and ELISA in HUVECs and EPCs treated with HtrA4 for 24 and 48h. RESULTS: We observed that HtrA4 significantly up-regulated IGFBP3, SERPINE1 and SERPINB2, which all promote senescence. IGFBP-3 protein was also significantly e …
The results were then validated by RT-PCR and ELISA in HUVECs and EPCs treated with HtrA4 for 24 and 48h. RESULTS: We observed that …
HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia.
Wang Y, Lim R, Nie G. Wang Y, et al. Sci Rep. 2019 Feb 25;9(1):2728. doi: 10.1038/s41598-019-39565-9. Sci Rep. 2019. PMID: 30804477 Free PMC article.
Here we investigated the impact of HtrA4 on endothelial proliferation and repair. We demonstrated that high levels of HtrA4 halted endothelial cell proliferation and significantly down-regulated a number of genes that are critical for cell cycle progression, includi …
Here we investigated the impact of HtrA4 on endothelial proliferation and repair. We demonstrated that high levels of HtrA4 ha …
Endoplasmic reticulum stress impairs trophoblast syncytialization through upregulation of HtrA4 and causes early-onset preeclampsia.
Yuan X, Liu X, Zhu F, Huang B, Lin L, Huang J, Wen L, Kilby MD, Baker PN, Fu Y, Wu W, Qi H, Tang J, Tong C. Yuan X, et al. J Hypertens. 2023 Dec 1;41(12):2095-2106. doi: 10.1097/HJH.0000000000003541. Epub 2023 Sep 18. J Hypertens. 2023. PMID: 37728094
BeWo cells were used to stimulate the effects of HtrA4 and ERS on syncytialization. RESULTS: HtrA4 expression was upregulated in EO-PE and positively correlated with ERS. HtrA4 activity was increased in preeclampsia. Under normoxia, HtrA4 overexpressio …
BeWo cells were used to stimulate the effects of HtrA4 and ERS on syncytialization. RESULTS: HtrA4 expression was upregulated …
Cellular substrates and pro-apoptotic function of the human HtrA4 protease.
Wenta T, Jarzab M, Rychlowski M, Borysiak M, Latala A, Zurawa-Janicka D, Filipek A, Lipinska B. Wenta T, et al. J Proteomics. 2019 Oct 30;209:103505. doi: 10.1016/j.jprot.2019.103505. Epub 2019 Aug 27. J Proteomics. 2019. PMID: 31470122
The recombinant HtrA4 degraded XIAP, the caspases, beta-tubulin and actin but not TCP1alpha or S100A6. ...Furthermore, the panel of potential HtrA4 partners may serve as a basis for future studies of HtrA4 function....
The recombinant HtrA4 degraded XIAP, the caspases, beta-tubulin and actin but not TCP1alpha or S100A6. ...Furthermore, the panel of p …
HtrA4 is required for human trophoblast stem cell differentiation into syncytiotrophoblast.
Thach B, Wang Y, Heng S, Nie G. Thach B, et al. Placenta. 2024 Mar 6;147:68-77. doi: 10.1016/j.placenta.2024.01.018. Epub 2024 Feb 1. Placenta. 2024. PMID: 38325051 Free article.
TSCs were then differentiated into STB and the success of syncytialization was confirmed by RT-PCR, IF and ELISA of known markers. TSCs were next stably transfected with a HtrA4-targetting CRISPR/Cas9 plasmid, and cells with severe HtrA4 knockdown (HtrA4-KD) …
TSCs were then differentiated into STB and the success of syncytialization was confirmed by RT-PCR, IF and ELISA of known markers. TSCs were …
Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia.
Inagaki A, Nishizawa H, Ota S, Suzuki M, Inuzuka H, Miyamura H, Sekiya T, Kurahashi H, Udagawa Y. Inagaki A, et al. Placenta. 2012 Nov;33(11):919-26. doi: 10.1016/j.placenta.2012.08.003. Epub 2012 Sep 8. Placenta. 2012. PMID: 22964307
Elevated expression levels of placental HtrA4 in pre-eclampsia patients were observed by qRT-PCR. Western blotting also showed an increased production of HtrA4 at the protein level in pre-eclamptic placentas. ...In contrast, the amount of HtrA4 protein in syn …
Elevated expression levels of placental HtrA4 in pre-eclampsia patients were observed by qRT-PCR. Western blotting also showed an inc …
Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin.
Tseng E, Yee Teoh SS, Wang Y, Nie G. Tseng E, et al. Placenta. 2019 Jan 15;76:51-53. doi: 10.1016/j.placenta.2019.01.001. Epub 2019 Jan 2. Placenta. 2019. PMID: 30638949
In this study, we found HtrA4 cleaved the key endothelial junctional protein VE-cadherin in vitro. HtrA4 at concentrations found in preeclampsia also cleaved VE-cadherin in HUVECs as an endothelial model, disrupted cell-cell connections and induced intercellular gap …
In this study, we found HtrA4 cleaved the key endothelial junctional protein VE-cadherin in vitro. HtrA4 at concentrations fou …
High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR.
Wang Y, La M, Pham T, Lovrecz GO, Nie G. Wang Y, et al. FASEB J. 2019 Apr;33(4):5058-5066. doi: 10.1096/fj.201802151RR. Epub 2019 Jan 2. FASEB J. 2019. PMID: 30601675
We first demonstrated that HtrA4 cleaved recombinant KDR in vitro. We then confirmed that HtrA4 reduced the level of KDR in HUVECs and inhibited the VEGFA-induced phosphorylation of Akt kinase, which is essential for downstream signaling. ...Our studies therefore su …
We first demonstrated that HtrA4 cleaved recombinant KDR in vitro. We then confirmed that HtrA4 reduced the level of KDR in HU …
44 results