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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2005 1
2006 1
2009 1
2010 1
2011 3
2012 5
2013 3
2014 2
2015 2
2016 3
2017 3
2018 3
2019 7
2020 4
2021 5
2022 6
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49 results
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Page 1
Quantitative metrics for drug-target ligandability.
Vukovic S, Huggins DJ. Vukovic S, et al. Among authors: huggins dj. Drug Discov Today. 2018 Jun;23(6):1258-1266. doi: 10.1016/j.drudis.2018.02.015. Epub 2018 Mar 6. Drug Discov Today. 2018. PMID: 29522887 Free article. Review.
Deglycase-activity oriented screening to identify DJ-1 inhibitors.
Maksimovic I, Finkin-Groner E, Fukase Y, Zheng Q, Sun S, Michino M, Huggins DJ, Myers RW, David Y. Maksimovic I, et al. Among authors: huggins dj. RSC Med Chem. 2021 Jun 2;12(7):1232-1238. doi: 10.1039/d1md00062d. eCollection 2021 Jul 21. RSC Med Chem. 2021. PMID: 34355187 Free PMC article.
Rational approaches to improving selectivity in drug design.
Huggins DJ, Sherman W, Tidor B. Huggins DJ, et al. J Med Chem. 2012 Feb 23;55(4):1424-44. doi: 10.1021/jm2010332. Epub 2012 Jan 12. J Med Chem. 2012. PMID: 22239221 Free PMC article. Review. No abstract available.
A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors.
Liang R, Tomita D, Sasaki Y, Ginn J, Michino M, Huggins DJ, Baxt L, Kargman S, Shahid M, Aso K, Duggan M, Stamford AW, DeStanchina E, Liverton N, Meinke PT, Foley MA, Phillips RE. Liang R, et al. Among authors: huggins dj. ACS Med Chem Lett. 2022 Feb 10;13(3):377-387. doi: 10.1021/acsmedchemlett.1c00448. eCollection 2022 Mar 10. ACS Med Chem Lett. 2022. PMID: 35300079
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
Fushimi M, Buck H, Balbach M, Gorovyy A, Ferreira J, Rossetti T, Kaur N, Levin LR, Buck J, Quast J, van den Heuvel J, Steegborn C, Finkin-Groner E, Kargman S, Michino M, Foley MA, Miller M, Liverton NJ, Huggins DJ, Meinke PT. Fushimi M, et al. Among authors: huggins dj. ACS Med Chem Lett. 2021 Jul 14;12(8):1283-1287. doi: 10.1021/acsmedchemlett.1c00273. eCollection 2021 Aug 12. ACS Med Chem Lett. 2021. PMID: 34413957 Free PMC article.
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Scott DE, Francis-Newton NJ, Marsh ME, Coyne AG, Fischer G, Moschetti T, Bayly AR, Sharpe TD, Haas KT, Barber L, Valenzano CR, Srinivasan R, Huggins DJ, Lee M, Emery A, Hardwick B, Ehebauer M, Dagostin C, Esposito A, Pellegrini L, Perrior T, McKenzie G, Blundell TL, Hyvönen M, Skidmore J, Venkitaraman AR, Abell C. Scott DE, et al. Among authors: huggins dj. Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5. doi: 10.1016/j.chembiol.2021.02.006. Epub 2021 Mar 3. Cell Chem Biol. 2021. PMID: 33662256 Free PMC article.
49 results