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The dark sides of the GPCR tree - research progress on understudied GPCRs.
Scharf MM, Humphrys LJ, Berndt S, Di Pizio A, Lehmann J, Liebscher I, Nicoli A, Niv MY, Peri L, Schihada H, Schulte G. Scharf MM, et al. Among authors: humphrys lj. Br J Pharmacol. 2024 Feb 10. doi: 10.1111/bph.16325. Online ahead of print. Br J Pharmacol. 2024. PMID: 38339984 Review.
Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain.
Szczepańska K, Karcz T, Dichiara M, Mogilski S, Kalinowska-Tłuścik J, Pilarski B, Leniak A, Pietruś W, Podlewska S, Popiołek-Barczyk K, Humphrys LJ, Ruiz-Cantero MC, Reiner-Link D, Leitzbach L, Łażewska D, Pockes S, Górka M, Zmysłowski A, Calmels T, Cobos EJ, Marrazzo A, Stark H, Bojarski AJ, Amata E, Kieć-Kononowicz K. Szczepańska K, et al. Among authors: humphrys lj. J Med Chem. 2023 Jul 27;66(14):9658-9683. doi: 10.1021/acs.jmedchem.3c00430. Epub 2023 Jul 7. J Med Chem. 2023. PMID: 37418295 Free PMC article.
Ergometrine stimulates histamine H2 receptors in the isolated human atrium.
Jacob H, Braekow P, Hofmann B, Kirchhefer U, Forster L, Mönnich D, Humphrys LJ, Pockes S, Neumann J, Gergs U. Jacob H, et al. Among authors: humphrys lj. Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec;396(12):3809-3822. doi: 10.1007/s00210-023-02573-8. Epub 2023 Jun 24. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 37354215 Free PMC article.
Clonidine stimulates force of contraction via histamine H2 receptors in the human atrium.
Neumann J, Pockes S, Humphrys LJ, Mönnich D, Forster L, Kirchhefer U, Hofmann B, Gergs U. Neumann J, et al. Among authors: humphrys lj. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan;397(1):617-626. doi: 10.1007/s00210-023-02635-x. Epub 2023 Jul 25. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37490122 Free PMC article.
Illuminating Neuropeptide Y Y4 Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools.
Gleixner J, Kopanchuk S, Grätz L, Tahk MJ, Laasfeld T, Veikšina S, Höring C, Gattor AO, Humphrys LJ, Müller C, Archipowa N, Köckenberger J, Heinrich MR, Kutta RJ, Rinken A, Keller M. Gleixner J, et al. Among authors: humphrys lj. ACS Pharmacol Transl Sci. 2024 Mar 20;7(4):1142-1168. doi: 10.1021/acsptsci.4c00013. eCollection 2024 Apr 12. ACS Pharmacol Transl Sci. 2024. PMID: 38633582
13 results