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The nicotine metabolite, cotinine, attenuates glutamate (NMDA) antagonist-related effects on the performance of the five choice serial reaction time task (5C-SRTT) in rats.
Terry AV Jr, Buccafusco JJ, Schade RF, Vandenhuerk L, Callahan PM, Beck WD, Hutchings EJ, Chapman JM, Li P, Bartlett MG. Terry AV Jr, et al. Among authors: hutchings ej. Biochem Pharmacol. 2012 Apr 1;83(7):941-51. doi: 10.1016/j.bcp.2011.12.043. Epub 2012 Jan 8. Biochem Pharmacol. 2012. PMID: 22244928 Free PMC article.