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2016 1
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2021 0
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Page 1
A Concise Synthesis of Forskolin.
Hylse O, Maier L, Kučera R, Perečko T, Svobodová A, Kubala L, Paruch K, Švenda J. Hylse O, et al. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12586-12589. doi: 10.1002/anie.201706809. Epub 2017 Sep 5. Angew Chem Int Ed Engl. 2017. PMID: 28782270
Diastereoselective Flexible Synthesis of Carbocyclic C-Nucleosides.
Maier L, Khirsariya P, Hylse O, Adla SK, Černová L, Poljak M, Krajčovičová S, Weis E, Drápela S, Souček K, Paruch K. Maier L, et al. Among authors: hylse o. J Org Chem. 2017 Apr 7;82(7):3382-3402. doi: 10.1021/acs.joc.6b02594. Epub 2017 Mar 20. J Org Chem. 2017. PMID: 28267331
BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors.
Paculová H, Kramara J, Šimečková Š, Fedr R, Souček K, Hylse O, Paruch K, Svoboda M, Mistrík M, Kohoutek J. Paculová H, et al. Among authors: hylse o. Tumour Biol. 2017 Oct;39(10):1010428317727479. doi: 10.1177/1010428317727479. Tumour Biol. 2017. PMID: 29025359 Free article.
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation.
Samadder P, Suchánková T, Hylse O, Khirsariya P, Nikulenkov F, Drápela S, Straková N, Vaňhara P, Vašíčková K, Kolářová H, Binó L, Bittová M, Ovesná P, Kollár P, Fedr R, Ešner M, Jaroš J, Hampl A, Krejčí L, Paruch K, Souček K. Samadder P, et al. Among authors: hylse o. Mol Cancer Ther. 2017 Sep;16(9):1831-1842. doi: 10.1158/1535-7163.MCT-17-0018. Epub 2017 Jun 15. Mol Cancer Ther. 2017. PMID: 28619751 Free article.
Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells.
Zemanova J, Hylse O, Collakova J, Vesely P, Oltova A, Borsky M, Zaprazna K, Kasparkova M, Janovska P, Verner J, Kohoutek J, Dzimkova M, Bryja V, Jaskova Z, Brychtova Y, Paruch K, Trbusek M. Zemanova J, et al. Among authors: hylse o. Oncotarget. 2016 Sep 20;7(38):62091-62106. doi: 10.18632/oncotarget.11388. Oncotarget. 2016. PMID: 27556692 Free PMC article.