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1,103 results

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Page 1
The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth.
Sandovici I, Georgopoulou A, Pérez-García V, Hufnagel A, López-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constância M. Sandovici I, et al. Dev Cell. 2022 Jan 10;57(1):63-79.e8. doi: 10.1016/j.devcel.2021.12.005. Epub 2021 Dec 27. Dev Cell. 2022. PMID: 34963058 Free PMC article.
The angiocrine effects of IGF2 on placental microvasculature expansion are mediated, in part, through IGF2R and angiopoietin-Tie2/TEK signaling. Additionally, IGF2 exerts IGF2R-ERK1/2-dependent pro-proliferative and angiogenic effects on primary feto-placental endot …
The angiocrine effects of IGF2 on placental microvasculature expansion are mediated, in part, through IGF2R and angiopoietin-Tie2/TEK …
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C.
Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T. Pluvinage JV, et al. Sci Transl Med. 2021 Dec;13(622):eabg2919. doi: 10.1126/scitranslmed.abg2919. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851695 Free PMC article.
Using unbiased genetic and proteomic screens, we identify insulin-like growth factor 2 receptor (IGF2R) as the binding partner of sCD22 on human myeloid cells. Targeted truncation of IGF2R revealed that sCD22 docks near critical mannose 6-phosphate-binding domains, …
Using unbiased genetic and proteomic screens, we identify insulin-like growth factor 2 receptor (IGF2R) as the binding partner of sCD …
Regulatory Roles of IGF2R in Insulin Secretion and Adaptive beta-Cell Proliferation.
Shirakawa J, De Jesus DF, Tsuno T, Basile G, Inoue R, Takatani T, Nishiyama A, Okawa ER, Tamura T, Terauchi Y, Kulkarni RN. Shirakawa J, et al. Diabetes. 2025 Dec 1;74(12):2351-2364. doi: 10.2337/db25-0215. Diabetes. 2025. PMID: 41042627 Free PMC article.
ARTICLE HIGHLIGHTS: The significance of insulin-like growth factor-2 receptor (IGF2R) in beta-cells remains unclear. To assess the physiological role of IGF2R in beta-cells, the effects of IGF2R deficiency in vivo and in vitro were investigated. IGF2R …
ARTICLE HIGHLIGHTS: The significance of insulin-like growth factor-2 receptor (IGF2R) in beta-cells remains unclear. To assess the ph …
IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages.
Wang X, Lin L, Lan B, Wang Y, Du L, Chen X, Li Q, Liu K, Hu M, Xue Y, Roberts AI, Shao C, Melino G, Shi Y, Wang Y. Wang X, et al. Sci Adv. 2020 Nov 25;6(48):eabb7389. doi: 10.1126/sciadv.abb7389. Print 2020 Nov. Sci Adv. 2020. PMID: 33239287 Free PMC article.
We demonstrate that IGF2 exhibits dual and opposing roles in controlling inflammatory phenotypes in macrophages by regulating glucose metabolism, relying on the dominant activation of the IGF2 receptor (IGF2R) by low-dose IGF2 (L-IGF2) and IGF1R by high-dose IGF2. IGF2R …
We demonstrate that IGF2 exhibits dual and opposing roles in controlling inflammatory phenotypes in macrophages by regulating glucose metabo …
Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate receptor mechanism and biological outcomes.
Brown J, Jones EY, Forbes BE. Brown J, et al. Vitam Horm. 2009;80:699-719. doi: 10.1016/S0083-6729(08)00625-0. Vitam Horm. 2009. PMID: 19251056 Review.
This review highlights recent advances in understanding the IGF2R structure and mechanism of interaction with its ligands, in particular IGF-II. Recent mutagenesis studies combined with the crystal structure of domains 11-14 in complex with IGF-II have mapped the sites of …
This review highlights recent advances in understanding the IGF2R structure and mechanism of interaction with its ligands, in particu …
IGF2R, KCNQ1, PLAGL1, and SNRPN DNA methylation is completed in bovine by the early antral follicle stage.
Lafontaine S, Sirard MA. Lafontaine S, et al. Mol Reprod Dev. 2022 Jul;89(7):290-297. doi: 10.1002/mrd.23621. Epub 2022 Jun 13. Mol Reprod Dev. 2022. PMID: 35698757
We hypothesized that in bovine oocytes, some of the methylation patterns on maternally imprinted genes are acquired in the last phase of folliculogenesis. The pyrosequencing analysis of IGF2R, KCNQ1, PLAGL1, and SNRPN imprinted genes showed no clear progression of methylat …
We hypothesized that in bovine oocytes, some of the methylation patterns on maternally imprinted genes are acquired in the last phase of fol …
Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy.
Bella P, Farini A, Banfi S, Parolini D, Tonna N, Meregalli M, Belicchi M, Erratico S, D'Ursi P, Bianco F, Legato M, Ruocco C, Sitzia C, Sangiorgi S, Villa C, D'Antona G, Milanesi L, Nisoli E, Mauri P, Torrente Y. Bella P, et al. EMBO Mol Med. 2020 Jan 9;12(1):e11019. doi: 10.15252/emmm.201911019. Epub 2019 Dec 2. EMBO Mol Med. 2020. PMID: 31793167 Free PMC article.
We found that IGF2R and the store-operated Ca(2+) channel CD20 share a common hydrophobic binding motif that stabilizes their association. ...Interestingly, we found that IGF2R expression was increased in dystrophic skeletal muscle of human DMD patients and mdx mice …
We found that IGF2R and the store-operated Ca(2+) channel CD20 share a common hydrophobic binding motif that stabilizes their associa …
Myocardial IGF2R is a critical mediator of inflammation and fibrosis after ischemia-reperfusion injury.
Wu Z, Huang W, He X, Dutta S, Paul C, Fan GC, Kanisicak O, Xu M, Liang J, Wang Y. Wu Z, et al. bioRxiv [Preprint]. 2023 Apr 24:2023.04.21.537835. doi: 10.1101/2023.04.21.537835. bioRxiv. 2023. PMID: 37131709 Free PMC article. Preprint.
Loss-of-function studies (including myocardial conditional knockout and CRISPR interference) were performed to clarify the role of IGF2R in I/R injuries. Following hypoxia, IGF2R expression increased, but this effect was reversed upon restoration of oxygen levels. . …
Loss-of-function studies (including myocardial conditional knockout and CRISPR interference) were performed to clarify the role of IGF2R …
Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis.
Martin-Kleiner I, Gall Troselj K. Martin-Kleiner I, et al. Cancer Lett. 2010 Mar 1;289(1):11-22. doi: 10.1016/j.canlet.2009.06.036. Epub 2009 Jul 30. Cancer Lett. 2010. PMID: 19646808 Review.
The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer. ...This review presents critical and focused highlights of dat …
The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is inv …
IGF2/IGF2R/Sting signaling as a therapeutic target in DSS-induced ulcerative colitis.
Chen L, Zhong XL, Cao WY, Mao ML, Liu DD, Liu WJ, Zu XY, Liu JH. Chen L, et al. Eur J Pharmacol. 2023 Dec 5;960:176122. doi: 10.1016/j.ejphar.2023.176122. Epub 2023 Oct 19. Eur J Pharmacol. 2023. PMID: 37863414
IGF2 expression was reduced in colon tissues but not plasma of DSS-induced colitis mice. IGF2R expression was also decreased in colitis colons, which was then elevated by recombinant IGF2. ...Additionally, IGF2 treatment can maintain colonic stemness and further repair col …
IGF2 expression was reduced in colon tissues but not plasma of DSS-induced colitis mice. IGF2R expression was also decreased in colit …
1,103 results