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1988 1
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2,172 results

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Page 1
IL2RA Promotes Aggressiveness and Stem Cell-Related Properties of Acute Myeloid Leukemia.
Nguyen CH, Schlerka A, Grandits AM, Koller E, van der Kouwe E, Vassiliou GS, Staber PB, Heller G, Wieser R. Nguyen CH, et al. Cancer Res. 2020 Oct 15;80(20):4527-4539. doi: 10.1158/0008-5472.CAN-20-0531. Epub 2020 Sep 1. Cancer Res. 2020. PMID: 32873636
The clinical potential of anti-IL2RA therapy is, therefore, being explored in early-stage clinical trials. Notwithstanding, only very limited information regarding the biological function of IL2RA in AML is available. Using genetic manipulation of IL2RA expre …
The clinical potential of anti-IL2RA therapy is, therefore, being explored in early-stage clinical trials. Notwithstanding, only very …
IL2RA is a prognostic indicator and correlated with immune characteristics of pancreatic ductal adenocarcinoma.
Fan L, Wang X, Chang Q, Wang Y, Yang W, Liu L. Fan L, et al. Medicine (Baltimore). 2022 Oct 21;101(42):e30966. doi: 10.1097/MD.0000000000030966. Medicine (Baltimore). 2022. PMID: 36281157 Free PMC article.
Wilcoxon rank sum test was conducted to compare the difference of immunological characteristics of PDAC samples between low IL2RA and high IL2RA. Spearman correlation analysis was used to explore the correlations of IL2RA expression and immune checkpoint gene …
Wilcoxon rank sum test was conducted to compare the difference of immunological characteristics of PDAC samples between low IL2RA and …
IL2RA(+)VSIG4(+) tumor-associated macrophage is a key subpopulation of the immunosuppressive microenvironment in anaplastic thyroid cancer.
Pan Z, Bao L, Lu X, Hu X, Li L, Chen J, Jin T, Zhang Y, Tan Z, Huang P, Ge M. Pan Z, et al. Biochim Biophys Acta Mol Basis Dis. 2023 Jan 1;1869(1):166591. doi: 10.1016/j.bbadis.2022.166591. Epub 2022 Oct 31. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 36328145 Free article.
Notably, we identified one ATC-specific subset, IL2RA(+) VSIG4(+) ATAMs, co-expressed M1 and M2 markers. The infiltration of IL2RA(+) VSIG4(+) ATAMs showed strong correlation with BRAF and RAS signaling, and its high infiltration was associated with favorable progno …
Notably, we identified one ATC-specific subset, IL2RA(+) VSIG4(+) ATAMs, co-expressed M1 and M2 markers. The infiltration of IL2RA …
IL2RA Methylation and Gene Expression in Relation to the Multiple Sclerosis-Associated Gene Variant rs2104286 and Soluble IL-2Ralpha in CD8(+) T Cells.
Buhelt S, Laigaard HM, von Essen MR, Ullum H, Oturai A, Sellebjerg F, Søndergaard HB. Buhelt S, et al. Front Immunol. 2021 Jul 27;12:676141. doi: 10.3389/fimmu.2021.676141. eCollection 2021. Front Immunol. 2021. PMID: 34386002 Free PMC article.
The interleukin-2 receptor alpha (IL-2Ralpha) is important for CD8(+) T cell function, and single nucleotide polymorphisms (SNPs) in the IL2RA gene encoding IL-2Ralpha increase the risk of MS. Therefore, in isolated CD8(+) T cells we investigated IL2RA gene methylat …
The interleukin-2 receptor alpha (IL-2Ralpha) is important for CD8(+) T cell function, and single nucleotide polymorphisms (SNPs) in the …
High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia.
Du W, He J, Zhou W, Shu S, Li J, Liu W, Deng Y, Lu C, Lin S, Ma Y, He Y, Zheng J, Zhu J, Bai L, Li X, Yao J, Hu D, Gu S, Li H, Guo A, Huang S, Feng X, Hu D. Du W, et al. J Transl Med. 2019 Jun 6;17(1):191. doi: 10.1186/s12967-019-1926-z. J Transl Med. 2019. PMID: 31171000 Free PMC article.
In core binding factor (CBF) AML, high IL2RA mRNA expression correlated with FLT3-ITD status (p = 0.023). Multivariable analyses revealed that high IL2RA expression (p = 0.002), along with c-KIT D816V status (p = 0.013) significantly predicted shorter RFS, whereas o …
In core binding factor (CBF) AML, high IL2RA mRNA expression correlated with FLT3-ITD status (p = 0.023). Multivariable analyses reve …
Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases.
Ohkura N, Sakaguchi S. Ohkura N, et al. Cell Res. 2020 Jun;30(6):465-474. doi: 10.1038/s41422-020-0324-7. Epub 2020 May 4. Cell Res. 2020. PMID: 32367041 Free PMC article. Review.
Furthermore, in humans, single nucleotide polymorphisms in Treg-specific DNA demethylated regions associated with Treg signature genes, such as IL2RA (CD25) and CTLA4, can affect the development and function of naive Treg cells rather than effector T cells. ...
Furthermore, in humans, single nucleotide polymorphisms in Treg-specific DNA demethylated regions associated with Treg signature genes, such …
Effect of PTPN22, FAS/FASL, IL2RA and CTLA4 genetic polymorphisms on the risk of developing alopecia areata: A systematic review of the literature and meta-analysis.
Gil-Quiñones SR, Sepúlveda-Pachón IT, Sánchez Vanegas G, Gutierrez-Castañeda LD. Gil-Quiñones SR, et al. PLoS One. 2021 Nov 4;16(11):e0258499. doi: 10.1371/journal.pone.0258499. eCollection 2021. PLoS One. 2021. PMID: 34735462 Free PMC article.
The aim of the current review was to synthesize the results of said studies to estimate the impact of FAS, FASL, PTPN22, CTLA4 and IL2RA gene polymorphisms on AA susceptibility. DESIGN: A systematic literature search was conducted in the Medline, Web of Science, Scopus, EM …
The aim of the current review was to synthesize the results of said studies to estimate the impact of FAS, FASL, PTPN22, CTLA4 and IL2RA …
Association of IL2RA and multiple sclerosis risk: A case control, systematic review, and meta-analysis study.
Rangani F, Rakhshi N, Kadkhoda Mezerji Z, Alikhah A, Dehghanzad R, Abbasi B, Ahmadi A, Nikravesh A, Pahlevan Kakhki M. Rangani F, et al. J Neurol Sci. 2025 May 15;472:123461. doi: 10.1016/j.jns.2025.123461. Epub 2025 Mar 10. J Neurol Sci. 2025. PMID: 40086235 Free article.
The interleukin-2 receptor alpha chain (IL2RA) gene has been implicated in multiple sclerosis (MS) susceptibility, particularly through the rs2104286 and rs12722489 SNPs. ...This study aimed to investigate the association of IL2RA SNPs with MS risk in eastern Irania …
The interleukin-2 receptor alpha chain (IL2RA) gene has been implicated in multiple sclerosis (MS) susceptibility, particularly throu …
Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk.
Jia Z, Zhang Z, Yang Q, Deng C, Li D, Ren L. Jia Z, et al. Int Immunopharmacol. 2019 Sep;74:105716. doi: 10.1016/j.intimp.2019.105716. Epub 2019 Jul 3. Int Immunopharmacol. 2019. PMID: 31279323

After stratification analysis, the results showed that IL2RA rs12569923 (non-smokers), IL2RA rs791588 (60 years old, non-drinkers, BMI < 24 kg/m(2)), IL2RA rs12722498 (60 years old, non-drinkers, BMI < 24 kg/m(2), female) and IL2RB rs2281089 (female, st

…
After stratification analysis, the results showed that IL2RA rs12569923 (non-smokers), IL2RA rs791588 (60 years old, non-drink …
KIAA0101 and IL2RA Were Identified as Core Genes in Hormone-Resistant Nephropathy.
Chen Y, Qian S, Chen Y, Liu K, Yin W, Luo X. Chen Y, et al. Dis Markers. 2022 Sep 17;2022:6545266. doi: 10.1155/2022/6545266. eCollection 2022. Dis Markers. 2022. PMID: 36164371 Free PMC article.
The seed gene obtained through the MCODE plug-in calculation was IL2RA, whose HALLMARK pathway was significantly enriched in the KRAS signaling pathway. ...Therefore, IL2RA and KIAA0101 can be used as diagnostic markers for hormone-resistant nephropathy....
The seed gene obtained through the MCODE plug-in calculation was IL2RA, whose HALLMARK pathway was significantly enriched in the KRAS …
2,172 results