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Did you mean inube (200 results)?
Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.
Deaton AM, Dubey A, Ward LD, Dornbos P, Flannick J; AMP-T2D-GENES Consortium; Yee E, Ticau S, Noetzli L, Parker MM, Hoffing RA, Willis C, Plekan ME, Holleman AM, Hinkle G, Fitzgerald K, Vaishnaw AK, Nioi P. Deaton AM, et al. Nat Commun. 2022 Jul 27;13(1):4319. doi: 10.1038/s41467-022-31757-8. Nat Commun. 2022. PMID: 35896531 Free PMC article.
Predicted loss of function (pLOF) variants in INHBE associate with lower WHRadjBMI and this association replicates in data from AMP-T2D-GENES. INHBE encodes a secreted protein, the hepatokine activin E. In vitro characterization of the most common INHBE pLOF …
Predicted loss of function (pLOF) variants in INHBE associate with lower WHRadjBMI and this association replicates in data from AMP-T …
Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.
Akbari P, Sosina OA, Bovijn J, Landheer K, Nielsen JB, Kim M, Aykul S, De T, Haas ME, Hindy G, Lin N, Dinsmore IR, Luo JZ, Hectors S, Geraghty B, Germino M, Panagis L, Parasoglou P, Walls JR, Halasz G, Atwal GS; Regeneron Genetics Center; DiscovEHR Collaboration; Jones M, LeBlanc MG, Still CD, Carey DJ, Giontella A, Orho-Melander M, Berumen J, Kuri-Morales P, Alegre-Díaz J, Torres JM, Emberson JR, Collins R, Rader DJ, Zambrowicz B, Murphy AJ, Balasubramanian S, Overton JD, Reid JG, Shuldiner AR, Cantor M, Abecasis GR, Ferreira MAR, Sleeman MW, Gusarova V, Altarejos J, Harris C, Economides AN, Idone V, Karalis K, Della Gatta G, Mirshahi T, Yancopoulos GD, Melander O, Marchini J, Tapia-Conyer R, Locke AE, Baras A, Verweij N, Lotta LA. Akbari P, et al. Nat Commun. 2022 Aug 23;13(1):4844. doi: 10.1038/s41467-022-32398-7. Nat Commun. 2022. PMID: 35999217 Free PMC article.
We describe an association with favorable fat distribution (p = 1.8 10(-09)), favorable metabolic profile and protection from type 2 diabetes (~28% lower odds; p = 0.004) for heterozygous protein-truncating mutations in INHBE, which encodes a circulating growth factor of …
We describe an association with favorable fat distribution (p = 1.8 10(-09)), favorable metabolic profile and protection from type 2 diabe …
Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids.
Griffin JD, Buxton JM, Culver JA, Barnes R, Jordan EA, White AR, Flaherty SE, Bernardo B, Ross T, Bence KK, Birnbaum MJ. Griffin JD, et al. Mol Metab. 2023 Dec;78:101830. doi: 10.1016/j.molmet.2023.101830. Epub 2023 Oct 28. Mol Metab. 2023. PMID: 38787338 Free PMC article.
RESULTS: Increasing hepatocyte NEFA exposure in vivo by inducing adipose lipolysis through fasting or CL 316,243 treatment increased hepatic Inhbe expression. Similarly, incubation of Huh7 human hepatocytes with fatty acids increased expression of INHBE. Genetic abl …
RESULTS: Increasing hepatocyte NEFA exposure in vivo by inducing adipose lipolysis through fasting or CL 316,243 treatment increased hepatic …
Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice.
Adam RC, Pryce DS, Lee JS, Zhao Y, Mintah IJ, Min S, Halasz G, Mastaitis J, Atwal GS, Aykul S, Idone V, Economides AN, Lotta LA, Murphy AJ, Yancopoulos GD, Sleeman MW, Gusarova V. Adam RC, et al. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2309967120. doi: 10.1073/pnas.2309967120. Epub 2023 Jul 31. Proc Natl Acad Sci U S A. 2023. PMID: 37523551 Free PMC article.
Body fat distribution is a heritable risk factor for cardiovascular and metabolic disease. In humans, rare Inhibin beta E (INHBE, activin E) loss-of-function variants are associated with a lower waist-to-hip ratio and protection from type 2 diabetes. Hepatic fatty acid sen …
Body fat distribution is a heritable risk factor for cardiovascular and metabolic disease. In humans, rare Inhibin beta E (INHBE, act …
Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease.
Cao J, Zhong Q, Huang Y, Zhu M, Wang Z, Xiong Z. Cao J, et al. Biochem Biophys Res Commun. 2023 Dec 17;686:149180. doi: 10.1016/j.bbrc.2023.149180. Epub 2023 Oct 30. Biochem Biophys Res Commun. 2023. PMID: 37922570
INHBE and P4HA1 were up-regulated and down-regulated in the steatosis hepatocyte model, respectively. Animal experiments also showed that INHBE was up-regulated in the liver of mice fed with high fat diet (HFD). CONCLUSION: INHBE and P4HA1 are the hub genes o …
INHBE and P4HA1 were up-regulated and down-regulated in the steatosis hepatocyte model, respectively. Animal experiments also showed …
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
Nault JC, Couchy G, Balabaud C, Morcrette G, Caruso S, Blanc JF, Bacq Y, Calderaro J, Paradis V, Ramos J, Scoazec JY, Gnemmi V, Sturm N, Guettier C, Fabre M, Savier E, Chiche L, Labrune P, Selves J, Wendum D, Pilati C, Laurent A, De Muret A, Le Bail B, Rebouissou S, Imbeaud S; GENTHEP Investigators; Bioulac-Sage P, Letouzé E, Zucman-Rossi J. Nault JC, et al. Gastroenterology. 2017 Mar;152(4):880-894.e6. doi: 10.1053/j.gastro.2016.11.042. Epub 2016 Dec 7. Gastroenterology. 2017. PMID: 27939373 Free article.
These tumors were characterized by activation of sonic hedgehog signaling, due to focal deletions that fuse the promoter of INHBE with GLI1. Analysis of genetic heterogeneity among multiple HCAs, from different patients, revealed a molecular subtype field effect; multiple …
These tumors were characterized by activation of sonic hedgehog signaling, due to focal deletions that fuse the promoter of INHBE wit …
The Significance of INHBE Expression in the Cancer Cells of Clear-Cell Renal Cell Carcinoma.
Xu ZB, Gan MF, Yu HY, Mo LC, Xia YH, Yu QX, Zheng JM. Xu ZB, et al. Urol Int. 2022;106(4):376-386. doi: 10.1159/000518161. Epub 2021 Aug 31. Urol Int. 2022. PMID: 34515260
No study has reported the expression of INHBE in kidney cancer. The purpose of this study was to examine the expressions of INHBE in the tumor tissue of patients with clear-cell renal cell carcinoma (ccRCC) and to explore the pathologic significance. METHODS: The …
No study has reported the expression of INHBE in kidney cancer. The purpose of this study was to examine the expressions of INHBE …
Activin E is a new guardian protecting against hepatic steatosis via inhibiting lipolysis in white adipose tissue.
Park SY, Cho Y, Son SM, Hur JH, Kim Y, Oh H, Lee HY, Jung S, Park S, Kim IY, Lee SJ, Choi CS. Park SY, et al. Exp Mol Med. 2025 Feb;57(2):466-477. doi: 10.1038/s12276-025-01403-6. Epub 2025 Feb 13. Exp Mol Med. 2025. PMID: 39948368 Free PMC article.
The deficiency of Inhbe resulted in increased lipolysis in adipose tissue, leading to increased fatty acid influx into the liver. Conversely, hepatic overexpression of Inhbe ameliorated hepatic steatosis by suppressing lipolysis in adipose tissue through ALK7-Smad s …
The deficiency of Inhbe resulted in increased lipolysis in adipose tissue, leading to increased fatty acid influx into the liver. Con …
Inhibin betaE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.
Sugiyama M, Kikuchi A, Misu H, Igawa H, Ashihara M, Kushima Y, Honda K, Suzuki Y, Kawabe Y, Kaneko S, Takamura T. Sugiyama M, et al. PLoS One. 2018 Mar 29;13(3):e0194798. doi: 10.1371/journal.pone.0194798. eCollection 2018. PLoS One. 2018. PMID: 29596463 Free PMC article.
Additionally, Inhbe gene expression increased in the livers of db/db mice, a rodent model of type 2 diabetes. To preliminarily screen the role of Inhbe in vivo in whole-body energy metabolic status, hepatic mRNA was knocked down with siRNA for Inhbe (siINHBE) …
Additionally, Inhbe gene expression increased in the livers of db/db mice, a rodent model of type 2 diabetes. To preliminarily screen …
Mechanistic insights into Y-Box binding protein-1 mediated regulation of lipid metabolism and oxidative stress in NAFLD via INHBE/TNF-beta pathway.
Ren Z, Wang R, Wei J, Ma Z, Ke X. Ren Z, et al. Biomol Biomed. 2025 May 8;25(7):1528-1539. doi: 10.17305/bb.2024.11249. Biomol Biomed. 2025. PMID: 39748602 Free PMC article.
Notably, we observed an increase in Inhibin beta E (INHBE) expression, while EGR1, GDF15, NUPR1, and FOSB were decreased in NAFLD LO2 cells. ...Specifically, we observed decreased levels of TGF-beta1, p-Smad2, and p-Smad3 following YB1 and INHBE knockdown. Furthermo …
Notably, we observed an increase in Inhibin beta E (INHBE) expression, while EGR1, GDF15, NUPR1, and FOSB were decreased in NAFLD LO2 …
77 results