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INPP4A/INPP4B and P-Rex proteins: related but different?
Rynkiewicz NK, Liu HJ, Balamatsias D, Mitchell CA. Rynkiewicz NK, et al. Adv Biol Regul. 2012 Jan;52(1):265-79. doi: 10.1016/j.advenzreg.2011.09.001. Adv Biol Regul. 2012. PMID: 21925199 Review. No abstract available.
Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.
Tran DM, Yoshioka N, Bizen N, Mori-Ochiai Y, Yano M, Yanai S, Hasegawa J, Miyashita S, Hoshino M, Sasaki J, Sasaki T, Takebayashi H. Tran DM, et al. Dis Model Mech. 2023 Jul 1;16(7):dmm050169. doi: 10.1242/dmm.050169. Epub 2023 Jul 28. Dis Model Mech. 2023. PMID: 37415561 Free PMC article.
Both strains exhibited reduced expression of Inpp4a mutant proteins in the cerebellum. N-terminal-truncated Inpp4a proteins were expressed from the Inpp4adeltaEx1,2 allele by alternative translation initiation and had phosphatase activity for PI(3,4)P2, whereas the …
Both strains exhibited reduced expression of Inpp4a mutant proteins in the cerebellum. N-terminal-truncated Inpp4a proteins we …
Cytosolic cytochrome c represses ferroptosis.
Song X, Zhou Z, Liu J, Li J, Yu C, Zeh HJ, Klionsky DJ, Stockwell BR, Wang J, Kang R, Kroemer G, Tang D. Song X, et al. Cell Metab. 2025 Jun 3;37(6):1326-1343.e10. doi: 10.1016/j.cmet.2025.03.014. Epub 2025 Apr 14. Cell Metab. 2025. PMID: 40233758
Mass spectrometry and site-directed mutagenesis revealed the existence of a cytosolic complex composed of inositol polyphosphate-4-phosphatase type I A (INPP4A) and CYCS. This CYCS-INPP4A complex is distinct from the CYCS-apoptotic peptidase activating factor 1 (APA …
Mass spectrometry and site-directed mutagenesis revealed the existence of a cytosolic complex composed of inositol polyphosphate-4-phosphata …
The hMeDIP-Seq identified INPP4A as a novel biomarker for eosinophilic chronic rhinosinusitis with nasal polyps.
Tan H, Tong X, Gao Z, Xu Y, Tan L, Zhang W, Xiang R, Xu Y. Tan H, et al. Epigenomics. 2022 Jun;14(12):757-775. doi: 10.2217/epi-2022-0053. Epub 2022 Jun 29. Epigenomics. 2022. PMID: 35765979
Consistent with their hydroxymethylation level, GNAL, INPP4A and IRF4 expression levels were significantly different between ECRSwNP and the other two groups. ...INPP4A mRNA was markedly decreased in ECRSwNP polyps and can predict ECRSwNP....
Consistent with their hydroxymethylation level, GNAL, INPP4A and IRF4 expression levels were significantly different between ECRSwNP …
Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps.
Xu Y, Tong X, Liu P, Huang J, Chen S, Liu D, Gu T, Xie Y, Guo D, Xu Y. Xu Y, et al. Inflamm Res. 2024 Apr;73(4):581-595. doi: 10.1007/s00011-024-01855-y. Epub 2024 Feb 16. Inflamm Res. 2024. PMID: 38363325
Inositol polyphosphate-4-phosphatase type IA (INPP4A), a lipid phosphatase, has been implicated in allergic asthma. However, the expression and function of INPP4A in E-CRSwNP remain unclear. This study aims to investigate the role of INPP4A in macrophages in …
Inositol polyphosphate-4-phosphatase type IA (INPP4A), a lipid phosphatase, has been implicated in allergic asthma. However, the expr …
Elucidating the clinical and genetic spectrum of inositol polyphosphate phosphatase INPP4A-related neurodevelopmental disorder.
Rawlins LE, Maroofian R, Cannon SJ, Daana M, Zamani M, Ghani S, Leslie JS, Ubeyratna N, Khan N, Khan H, Scardamaglia A, Cloarec R, Khan SA, Umair M, Sadeghian S, Galehdari H, Al-Maawali A, Al-Kindi A, Azizimalamiri R, Shariati G, Ahmad F, Al-Futaisi A, Rodriguez Cruz PM, Salazar-Villacorta A, Ndiaye M, Diop AG, Sedaghat A, Saberi A, Hamid M, Zaki MS, Vona B, Owrang D, Alhashem AM, Obeid M, Khan A, Beydoun A, Najjar M, Tajsharghi H, Zifarelli G, Bauer P, Hakami WS, Al Hashem AM, Boustany RN, Burglen L, Alavi S, Gunning AC, Owens M, Karimiani EG, Gleeson JG, Milh M, Salah S, Khan J, Haucke V, Wright CF, McGavin L, Elpeleg O, Shabbir MI, Houlden H, Ebner M, Baple EL, Crosby AH. Rawlins LE, et al. Genet Med. 2025 Feb;27(2):101278. doi: 10.1016/j.gim.2024.101278. Epub 2024 Sep 21. Genet Med. 2025. PMID: 39315527 Free article.
PURPOSE: Biallelic INPP4A variants have recently been associated with severe neurodevelopmental disease in single-case reports. ...CONCLUSION: Our studies comprehensively characterize INPP4A-related neurodevelopmental disorder and suggest genotype-specific clinical …
PURPOSE: Biallelic INPP4A variants have recently been associated with severe neurodevelopmental disease in single-case reports. ...CO …
Plausible role of INPP4A dysregulation in idiopathic pulmonary fibrosis.
Arvind M, Pattnaik B, Gheware A, Prakash YS, Srivastava M, Agrawal A, Bhatraju NK. Arvind M, et al. Physiol Rep. 2024 May;12(9):e16032. doi: 10.14814/phy2.16032. Physiol Rep. 2024. PMID: 38720166 Free PMC article.
In the current study, we made an attempt to understand the regulation of INPP4A in idiopathic pulmonary fibrosis (IPF). Through integration of relevant INPP4A gene expression data from public repositories with our results from in vitro experiments and mouse models, …
In the current study, we made an attempt to understand the regulation of INPP4A in idiopathic pulmonary fibrosis (IPF). Through integ …
INPP4A-related genetic and phenotypic spectrum and functional relevance of subcellular targeting of INPP4A isoforms.
Hecher L, Harms FL, Lisfeld J, Alawi M, Denecke J, Kutsche K. Hecher L, et al. Neurogenetics. 2023 Apr;24(2):79-93. doi: 10.1007/s10048-023-00709-9. Epub 2023 Jan 19. Neurogenetics. 2023. PMID: 36653678
INPP4A produces multiple transcripts encoding shorter and longer INPP4A isoforms with hydrophilic or hydrophobic C-terminus. ...The level of mutant INPP4A mRNAs in proband-derived leukocytes was comparable to controls suggesting production of C-terminally alt …
INPP4A produces multiple transcripts encoding shorter and longer INPP4A isoforms with hydrophilic or hydrophobic C-terminus. . …
MicroRNA-223-3p regulates allergic inflammation by targeting INPP4A.
Zhou Y, Zhang T, Yan Y, You B, You Y, Zhang W, Chen J. Zhou Y, et al. Braz J Otorhinolaryngol. 2021 Sep-Oct;87(5):591-600. doi: 10.1016/j.bjorl.2020.05.020. Epub 2020 Jun 25. Braz J Otorhinolaryngol. 2021. PMID: 32631807 Free PMC article.
Subsequently, we demonstrated for the first time that microRNA-223-3p negatively regulated INPP4A expression by binding with the 3' untranslated region (3'UTR) of INPP4A. CONCLUSIONS: These findings indicate that microRNA-223-3p plays an important role in regulating …
Subsequently, we demonstrated for the first time that microRNA-223-3p negatively regulated INPP4A expression by binding with the 3' u …
A novel INPP4A mutation with pontocerebellar hypoplasia, myoclonic epilepsy, microcephaly, and severe developmental delay.
Özkan Kart P, Citli S, Yildiz N, Cansu A. Özkan Kart P, et al. Brain Dev. 2023 May;45(5):300-305. doi: 10.1016/j.braindev.2023.01.006. Epub 2023 Feb 8. Brain Dev. 2023. PMID: 36759255
CASE REPORTS: A seven-year-old girl with pontocerebellar hypoplasia, resistant myoclonic epilepsy with axial hypotonia, microcephaly, atypical facial appearance, nystagmus, ophthalmoplegia, hyperactive tendon reflexes, spasticity, clonus, extensor plantar response, contractures i …
CASE REPORTS: A seven-year-old girl with pontocerebellar hypoplasia, resistant myoclonic epilepsy with axial hypotonia, microcephaly, atypic …
61 results