Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
2007 1
2009 1
2010 3
2011 7
2012 10
2013 8
2014 24
2015 21
2016 18
2017 19
2018 13
2019 10
2020 17
2021 22
2022 19
2023 3
Text availability
Article attribute
Article type
Publication date

Search Results

172 results
Results by year
Filters applied: . Clear all
Page 1
The INPP4B paradox: Like PTEN, but different.
Hamila SA, Ooms LM, Rodgers SJ, Mitchell CA. Hamila SA, et al. Adv Biol Regul. 2021 Dec;82:100817. doi: 10.1016/j.jbior.2021.100817. Epub 2021 Jun 16. Adv Biol Regul. 2021. PMID: 34216856 Review.
However, evidence has since emerged revealing INPP4B as a paradoxical oncogene in several malignancies, with increased INPP4B expression reported in AML, melanoma and colon cancers among others. ...Nevertheless, research is ongoing to identify the factors that dicta …
However, evidence has since emerged revealing INPP4B as a paradoxical oncogene in several malignancies, with increased INPP4B …
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer.
Rodgers SJ, Ooms LM, Oorschot VMJ, Schittenhelm RB, Nguyen EV, Hamila SA, Rynkiewicz N, Gurung R, Eramo MJ, Sriratana A, Fedele CG, Caramia F, Loi S, Kerr G, Abud HE, Ramm G, Papa A, Ellisdon AM, Daly RJ, McLean CA, Mitchell CA. Rodgers SJ, et al. Nat Commun. 2021 May 25;12(1):3140. doi: 10.1038/s41467-021-23241-6. Nat Commun. 2021. PMID: 34035258 Free PMC article.
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P(2) to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to P …
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P(2) to PI(3)P and INPP4B inactivation is common in triple-negative …
INPP4B exerts a dual role in gastric cancer progression and prognosis.
Wu Y, Wang X, Lu Y, Wang H, Wang M, You Y, Su X, Sun D, Sun Y, Li Y. Wu Y, et al. J Cancer. 2021 Oct 22;12(23):7201-7213. doi: 10.7150/jca.58397. eCollection 2021. J Cancer. 2021. PMID: 34729121 Free PMC article.
Our study aimed to investigate the function and clinical relevance of INPP4B in GC. INPP4B expression was detected in GC tissues and nontumour tissues. ...Mechanistically, we found that INPP4B overexpression enhanced the phosphorylation of SGK3 (p-SGK3) in AG …
Our study aimed to investigate the function and clinical relevance of INPP4B in GC. INPP4B expression was detected in GC tissu …
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Sun X, Chen Y, Tao X, Zhang W, Wang X, Wang X, Ruan Z, Chen Z. Sun X, et al. Front Oncol. 2022 Sep 6;12:983537. doi: 10.3389/fonc.2022.983537. eCollection 2022. Front Oncol. 2022. PMID: 36147923 Free PMC article.
Notably, whether INPP4B participates in immune escape of glioma deserves urgent attention. ...Thus, INPP4B may constitute a valuable target for glioma treatment....
Notably, whether INPP4B participates in immune escape of glioma deserves urgent attention. ...Thus, INPP4B may constitute a va …
INPP4B protects from metabolic syndrome and associated disorders.
Zhang M, Ceyhan Y, Kaftanovskaya EM, Vasquez JL, Vacher J, Knop FK, Nathanson L, Agoulnik AI, Ittmann MM, Agoulnik IU. Zhang M, et al. Commun Biol. 2021 Mar 26;4(1):416. doi: 10.1038/s42003-021-01940-6. Commun Biol. 2021. PMID: 33772116 Free PMC article.
INPP4B suppresses AKT and PKC signaling in the liver thereby improving insulin sensitivity. ...When treated with high fat diet, Inpp4b(-/-) males develop type II diabetes and inflammation of adipose tissue and prostate. ...
INPP4B suppresses AKT and PKC signaling in the liver thereby improving insulin sensitivity. ...When treated with high fat diet, In …
INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.
Jin H, Yang L, Wang L, Yang Z, Zhan Q, Tao Y, Zou Q, Tang Y, Xian J, Zhang S, Jing Y, Zhang L. Jin H, et al. J Exp Clin Cancer Res. 2018 Jan 17;37(1):8. doi: 10.1186/s13046-018-0675-9. J Exp Clin Cancer Res. 2018. PMID: 29343273 Free PMC article.
RESULTS: High expression of INPP4B was observed in NPM1-mutated AML. Knockdown of INPP4B repressed cell proliferation in OCI-AML3 cells, whereas recovered INPP4B rescued this inhibitory effect in vitro. ...SGK3 was required for INPP4B-induced cell prol …
RESULTS: High expression of INPP4B was observed in NPM1-mutated AML. Knockdown of INPP4B repressed cell proliferation in OCI-A …
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Liu H, Paddock MN, Wang H, Murphy CJ, Geck RC, Navarro AJ, Wulf GM, Elemento O, Haucke V, Cantley LC, Toker A. Liu H, et al. Cancer Discov. 2020 Aug;10(8):1226-1239. doi: 10.1158/2159-8290.CD-19-1262. Epub 2020 Jun 8. Cancer Discov. 2020. PMID: 32513774 Free PMC article.
Inactivation of the tumor suppressor lipid phosphatase INPP4B is common in triple-negative breast cancer (TNBC). We generated a genetically engineered TNBC mouse model deficient in INPP4B. ...INPP4B regulates RTK trafficking and degradation, such that loss of …
Inactivation of the tumor suppressor lipid phosphatase INPP4B is common in triple-negative breast cancer (TNBC). We generated a genet …
Endosome and INPP4B.
Chew CL, Chen M, Pandolfi PP. Chew CL, et al. Oncotarget. 2016 Jan 5;7(1):5-6. doi: 10.18632/oncotarget.6663. Oncotarget. 2016. PMID: 26700619 Free PMC article. No abstract available.
INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma.
Tang W, Yang L, Yang T, Liu M, Zhou Y, Lin J, Wang K, Ding C. Tang W, et al. Onco Targets Ther. 2019 May 7;12:3491-3507. doi: 10.2147/OTT.S196832. eCollection 2019. Onco Targets Ther. 2019. PMID: 31123408 Free PMC article.
Materials and methods: We evaluated the expression of INPP4B in 86 cases of paired human HCC samples by immunohistochemistry, and the clinical significance of INPP4B expression was analyzed. ...Furthermore, INPP4B was found to inhibit the activation of PI3K/A …
Materials and methods: We evaluated the expression of INPP4B in 86 cases of paired human HCC samples by immunohistochemistry, and the …
INPP4B: the new kid on the PI3K block.
Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM. Agoulnik IU, et al. Oncotarget. 2011 Apr;2(4):321-8. doi: 10.18632/oncotarget.260. Oncotarget. 2011. PMID: 21487159 Free PMC article. Review.
Recently, another lipid phosphatase, Inositol Polyphosphate 4-phosphatase type II (INPP4B), has emerged as a potential tumor suppressor in prostate, breast, and ovarian cancers and possibly in leukemia. We will review its structure and function, crosstalk with androgen rec …
Recently, another lipid phosphatase, Inositol Polyphosphate 4-phosphatase type II (INPP4B), has emerged as a potential tumor suppress …
172 results