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Year Number of Results
2006 1
2007 1
2009 1
2010 3
2011 7
2012 10
2013 8
2014 24
2015 21
2016 18
2017 19
2018 13
2019 10
2020 17
2021 22
2022 19
2023 14
2024 5

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187 results

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Page 1
The INPP4B paradox: Like PTEN, but different.
Hamila SA, Ooms LM, Rodgers SJ, Mitchell CA. Hamila SA, et al. Adv Biol Regul. 2021 Dec;82:100817. doi: 10.1016/j.jbior.2021.100817. Epub 2021 Jun 16. Adv Biol Regul. 2021. PMID: 34216856 Review.
However, evidence has since emerged revealing INPP4B as a paradoxical oncogene in several malignancies, with increased INPP4B expression reported in AML, melanoma and colon cancers among others. ...Nevertheless, research is ongoing to identify the factors that dicta …
However, evidence has since emerged revealing INPP4B as a paradoxical oncogene in several malignancies, with increased INPP4B
INPP4B promotes PI3Kalpha-dependent late endosome formation and Wnt/beta-catenin signaling in breast cancer.
Rodgers SJ, Ooms LM, Oorschot VMJ, Schittenhelm RB, Nguyen EV, Hamila SA, Rynkiewicz N, Gurung R, Eramo MJ, Sriratana A, Fedele CG, Caramia F, Loi S, Kerr G, Abud HE, Ramm G, Papa A, Ellisdon AM, Daly RJ, McLean CA, Mitchell CA. Rodgers SJ, et al. Nat Commun. 2021 May 25;12(1):3140. doi: 10.1038/s41467-021-23241-6. Nat Commun. 2021. PMID: 34035258 Free PMC article.
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P(2) to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to P
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P(2) to PI(3)P and INPP4B inactivation is common in triple-negative
INPP4B exerts a dual role in gastric cancer progression and prognosis.
Wu Y, Wang X, Lu Y, Wang H, Wang M, You Y, Su X, Sun D, Sun Y, Li Y. Wu Y, et al. J Cancer. 2021 Oct 22;12(23):7201-7213. doi: 10.7150/jca.58397. eCollection 2021. J Cancer. 2021. PMID: 34729121 Free PMC article.
Our study aimed to investigate the function and clinical relevance of INPP4B in GC. INPP4B expression was detected in GC tissues and nontumour tissues. ...Mechanistically, we found that INPP4B overexpression enhanced the phosphorylation of SGK3 (p-SGK3) in AG …
Our study aimed to investigate the function and clinical relevance of INPP4B in GC. INPP4B expression was detected in GC tissu …
Endosome and INPP4B.
Chew CL, Chen M, Pandolfi PP. Chew CL, et al. Oncotarget. 2016 Jan 5;7(1):5-6. doi: 10.18632/oncotarget.6663. Oncotarget. 2016. PMID: 26700619 Free PMC article. No abstract available.
INPP4B protects from metabolic syndrome and associated disorders.
Zhang M, Ceyhan Y, Kaftanovskaya EM, Vasquez JL, Vacher J, Knop FK, Nathanson L, Agoulnik AI, Ittmann MM, Agoulnik IU. Zhang M, et al. Commun Biol. 2021 Mar 26;4(1):416. doi: 10.1038/s42003-021-01940-6. Commun Biol. 2021. PMID: 33772116 Free PMC article.
INPP4B suppresses AKT and PKC signaling in the liver thereby improving insulin sensitivity. ...When treated with high fat diet, Inpp4b(-/-) males develop type II diabetes and inflammation of adipose tissue and prostate. ...
INPP4B suppresses AKT and PKC signaling in the liver thereby improving insulin sensitivity. ...When treated with high fat diet, In
INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.
Jin H, Yang L, Wang L, Yang Z, Zhan Q, Tao Y, Zou Q, Tang Y, Xian J, Zhang S, Jing Y, Zhang L. Jin H, et al. J Exp Clin Cancer Res. 2018 Jan 17;37(1):8. doi: 10.1186/s13046-018-0675-9. J Exp Clin Cancer Res. 2018. PMID: 29343273 Free PMC article.
RESULTS: High expression of INPP4B was observed in NPM1-mutated AML. Knockdown of INPP4B repressed cell proliferation in OCI-AML3 cells, whereas recovered INPP4B rescued this inhibitory effect in vitro. ...SGK3 was required for INPP4B-induced cell prol …
RESULTS: High expression of INPP4B was observed in NPM1-mutated AML. Knockdown of INPP4B repressed cell proliferation in OCI-A …
INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma.
Tang W, Yang L, Yang T, Liu M, Zhou Y, Lin J, Wang K, Ding C. Tang W, et al. Onco Targets Ther. 2019 May 7;12:3491-3507. doi: 10.2147/OTT.S196832. eCollection 2019. Onco Targets Ther. 2019. PMID: 31123408 Free PMC article.
Materials and methods: We evaluated the expression of INPP4B in 86 cases of paired human HCC samples by immunohistochemistry, and the clinical significance of INPP4B expression was analyzed. ...Furthermore, INPP4B was found to inhibit the activation of PI3K/A …
Materials and methods: We evaluated the expression of INPP4B in 86 cases of paired human HCC samples by immunohistochemistry, and the …
Tumor Suppressor Role of INPP4B in Chemoresistant Retinoblastoma.
Miroschnikov N, Dräger O, Van Meenen D, Metz K, Budeus B, Dünker N, Busch MA. Miroschnikov N, et al. J Oncol. 2023 Mar 8;2023:2270097. doi: 10.1155/2023/2270097. eCollection 2023. J Oncol. 2023. PMID: 36993823 Free PMC article.
In the study presented, we investigated the expression of INPP4B in RB cell lines and patients and analyzed the effect of INPP4B overexpression on etoposide resistant RB cell growth in vitro and in vivo. ...RNAseq analysis of INPP4B overexpressing, etoposide- …
In the study presented, we investigated the expression of INPP4B in RB cell lines and patients and analyzed the effect of INPP4B
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Sun X, Chen Y, Tao X, Zhang W, Wang X, Wang X, Ruan Z, Chen Z. Sun X, et al. Front Oncol. 2022 Sep 6;12:983537. doi: 10.3389/fonc.2022.983537. eCollection 2022. Front Oncol. 2022. PMID: 36147923 Free PMC article.
Notably, whether INPP4B participates in immune escape of glioma deserves urgent attention. ...Thus, INPP4B may constitute a valuable target for glioma treatment....
Notably, whether INPP4B participates in immune escape of glioma deserves urgent attention. ...Thus, INPP4B may constitute a va …
INPP4B: the new kid on the PI3K block.
Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM. Agoulnik IU, et al. Oncotarget. 2011 Apr;2(4):321-8. doi: 10.18632/oncotarget.260. Oncotarget. 2011. PMID: 21487159 Free PMC article. Review.
Recently, another lipid phosphatase, Inositol Polyphosphate 4-phosphatase type II (INPP4B), has emerged as a potential tumor suppressor in prostate, breast, and ovarian cancers and possibly in leukemia. We will review its structure and function, crosstalk with androgen rec …
Recently, another lipid phosphatase, Inositol Polyphosphate 4-phosphatase type II (INPP4B), has emerged as a potential tumor suppress …
187 results