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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 2
1958 2
1982 1
1983 1
1984 1
1993 1
2000 1
2002 1
2003 1
2004 1
2006 1
2007 3
2008 5
2009 4
2010 6
2011 7
2012 3
2013 5
2014 5
2015 8
2016 4
2017 11
2018 11
2019 12
2020 14
2021 12
2022 10
2023 13
2024 5

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136 results

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Page 1
C9orf72-mediated ALS and FTD: multiple pathways to disease.
Balendra R, Isaacs AM. Balendra R, et al. Among authors: isaacs am. Nat Rev Neurol. 2018 Sep;14(9):544-558. doi: 10.1038/s41582-018-0047-2. Nat Rev Neurol. 2018. PMID: 30120348 Free PMC article. Review.
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.
Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IOC, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, Hendrich O, Fratta P, Fisher EMC, Partridge L, Isaacs AM. Mizielinska S, et al. Among authors: isaacs am. Science. 2014 Sep 5;345(6201):1192-1194. doi: 10.1126/science.1256800. Epub 2014 Aug 7. Science. 2014. PMID: 25103406 Free PMC article.
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.
Vahsen BF, Nalluru S, Morgan GR, Farrimond L, Carroll E, Xu Y, Cramb KML, Amein B, Scaber J, Katsikoudi A, Candalija A, Carcolé M, Dafinca R, Isaacs AM, Wade-Martins R, Gray E, Turner MR, Cowley SA, Talbot K. Vahsen BF, et al. Among authors: isaacs am. Nat Commun. 2023 Sep 22;14(1):5898. doi: 10.1038/s41467-023-41603-0. Nat Commun. 2023. PMID: 37736756 Free PMC article.
CHMP2B Frontotemporal Dementia.
Roos P, Holm IE, Nielsen JE, Nielsen TT, Brown JM, Johannsen P, Isaacs AM. Roos P, et al. Among authors: isaacs am. 2007 Aug 23 [updated 2020 Jul 2]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2007 Aug 23 [updated 2020 Jul 2]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301378 Free Books & Documents. Review.
Ageing as a risk factor for ALS/FTD.
Niccoli T, Partridge L, Isaacs AM. Niccoli T, et al. Among authors: isaacs am. Hum Mol Genet. 2017 Oct 1;26(R2):R105-R113. doi: 10.1093/hmg/ddx247. Hum Mol Genet. 2017. PMID: 28977441 Review.
Opinion: more mouse models and more translation needed for ALS.
Fisher EMC, Greensmith L, Malaspina A, Fratta P, Hanna MG, Schiavo G, Isaacs AM, Orrell RW, Cunningham TJ, Arozena AA. Fisher EMC, et al. Among authors: isaacs am. Mol Neurodegener. 2023 May 4;18(1):30. doi: 10.1186/s13024-023-00619-2. Mol Neurodegener. 2023. PMID: 37143081 Free PMC article. Review.
Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides.
Balendra R, Ruiz de Los Mozos I, Odeh HM, Glaria I, Milioto C, Wilson KM, Ule AM, Hallegger M, Masino L, Martin S, Patani R, Shorter J, Ule J, Isaacs AM. Balendra R, et al. Among authors: isaacs am. Life Sci Alliance. 2023 Jul 12;6(9):e202201824. doi: 10.26508/lsa.202201824. Print 2023 Sep. Life Sci Alliance. 2023. PMID: 37438085 Free PMC article.
Genetic models of C9orf72: what is toxic?
Moens TG, Partridge L, Isaacs AM. Moens TG, et al. Among authors: isaacs am. Curr Opin Genet Dev. 2017 Jun;44:92-101. doi: 10.1016/j.gde.2017.01.006. Epub 2017 Mar 29. Curr Opin Genet Dev. 2017. PMID: 28364657 Review.
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.
Milioto C, Carcolé M, Giblin A, Coneys R, Attrebi O, Ahmed M, Harris SS, Lee BI, Yang M, Ellingford RA, Nirujogi RS, Biggs D, Salomonsson S, Zanovello M, de Oliveira P, Katona E, Glaria I, Mikheenko A, Geary B, Udine E, Vaizoglu D, Anoar S, Jotangiya K, Crowley G, Smeeth DM, Adams ML, Niccoli T, Rademakers R, van Blitterswijk M, Devoy A, Hong S, Partridge L, Coyne AN, Fratta P, Alessi DR, Davies B, Busche MA, Greensmith L, Fisher EMC, Isaacs AM. Milioto C, et al. Among authors: isaacs am. Nat Neurosci. 2024 Apr;27(4):643-655. doi: 10.1038/s41593-024-01589-4. Epub 2024 Feb 29. Nat Neurosci. 2024. PMID: 38424324 Free PMC article.
Frontotemporal dementia caused by CHMP2B mutations.
Isaacs AM, Johannsen P, Holm I, Nielsen JE; FReJA consortium. Isaacs AM, et al. Curr Alzheimer Res. 2011 May;8(3):246-51. doi: 10.2174/156720511795563764. Curr Alzheimer Res. 2011. PMID: 21222599 Free PMC article. Review.
136 results