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Year Number of Results
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301 results

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Page 1
Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
Moye AL, Dost AF, Ietswaart R, Sengupta S, Ya V, Aluya C, Fahey CG, Louie SM, Paschini M, Kim CF. Moye AL, et al. EMBO J. 2024 Jul;43(14):2843-2861. doi: 10.1038/s44318-024-00113-5. Epub 2024 May 16. EMBO J. 2024. PMID: 38755258 Free PMC article.
The injury state in AT2(KRAS) cells of patients, mice, and organoids was distinguishable from AT2(WT) states via altered receptor expression, including co-expression of ITGA3 and SRC. The combination of clinically relevant KRAS(G12D) and SRC inhibitors impaired AT2(KRAS) o …
The injury state in AT2(KRAS) cells of patients, mice, and organoids was distinguishable from AT2(WT) states via altered receptor expression …
ITGA3-MET interaction promotes papillary thyroid cancer progression via ERK and PI3K/AKT pathways.
Lan Y, Liu D, Liang B, Song X, Xie L, Peng H, Guo H, Hong C, Weng X, Wei X, Liao X, Liang R, Huang D, Liu M. Lan Y, et al. Ann Med. 2025 Dec;57(1):2483379. doi: 10.1080/07853890.2025.2483379. Epub 2025 Mar 26. Ann Med. 2025. PMID: 40138447 Free PMC article.
BACKGROUND: Studies have examined the role of integrin alpha3 (ITGA3) in papillary thyroid carcinoma (PTC). However, the functional and molecular mechanism by which ITGA3 is involved in the progression of PTC remains poorly understood. ...ITGA3-MET cooperatio …
BACKGROUND: Studies have examined the role of integrin alpha3 (ITGA3) in papillary thyroid carcinoma (PTC). However, the functional a …
YY1/ITGA3 pathway may affect trophoblastic cells migration and invasion ability.
Wang Y, Yang D, Zhu R, Dai F, Yuan M, Zhang L, Zheng Y, Liu S, Yang X, Cheng Y. Wang Y, et al. J Reprod Immunol. 2022 Sep;153:103666. doi: 10.1016/j.jri.2022.103666. Epub 2022 Jul 26. J Reprod Immunol. 2022. PMID: 35970081
Chip-seq dataset analysis results predict YY1 can regulate ITGA3/7 expression by binding to the promoter region of ITGA3/7. Furthermore, results from chip experiment, RT-PCR, Dual-luciferase reporter gene assay showed that YY1 was able to bind to the promoter region …
Chip-seq dataset analysis results predict YY1 can regulate ITGA3/7 expression by binding to the promoter region of ITGA3/7. Fu …
ITGA3 participates in the pathogenesis of recurrent spontaneous abortion by downregulating ULK1-mediated autophagy to inhibiting trophoblast function.
Wang R, Dai F, Deng Z, Tang L, Liu H, Xia L, Cheng Y. Wang R, et al. Am J Physiol Cell Physiol. 2025 Jun 1;328(6):C1941-C1956. doi: 10.1152/ajpcell.00563.2024. Epub 2024 Oct 22. Am J Physiol Cell Physiol. 2025. PMID: 39437445 Free article.
Subsequent in vitro analyses indicated that ITGA3 knockdown inhibited the migration, invasion, and proliferation of trophoblast cells. ...ITGA3 facilitates the expression of ULK1, thereby promoting autophagy formation and elevating autophagy levels in trophoblast ce …
Subsequent in vitro analyses indicated that ITGA3 knockdown inhibited the migration, invasion, and proliferation of trophoblast cells …
ITGA3 interacts with VASP to regulate stemness and epithelial-mesenchymal transition of breast cancer cells.
Zhang H, Cui X, Cao A, Li X, Li L. Zhang H, et al. Gene. 2020 Apr 15;734:144396. doi: 10.1016/j.gene.2020.144396. Epub 2020 Jan 25. Gene. 2020. PMID: 31987909
However, the mechanism of ITGA3 in breast cancer is unknown. METHODS: The impact of ITGA3 on the biological features of breast cancer cells was explored using the Transwell and wound healing assays. ...Our findings indicate that ITGA3 interacts with VASP and …
However, the mechanism of ITGA3 in breast cancer is unknown. METHODS: The impact of ITGA3 on the biological features of breast …
ITGA3 serves as a diagnostic and prognostic biomarker for pancreatic cancer.
Jiao Y, Li Y, Liu S, Chen Q, Liu Y. Jiao Y, et al. Onco Targets Ther. 2019 May 27;12:4141-4152. doi: 10.2147/OTT.S201675. eCollection 2019. Onco Targets Ther. 2019. PMID: 31213833 Free PMC article.
Survival analysis and Cox regression analysis were used to examine the prognostic value of ITGA3 expression. Gene Set Enrichment Analysis (GSEA) was used to identify signaling pathways related to ITGA3 expression. ...Cox analysis indicated that high ITGA3 exp …
Survival analysis and Cox regression analysis were used to examine the prognostic value of ITGA3 expression. Gene Set Enrichment Anal …
ITGA3 acts as a purity-independent biomarker of both immunotherapy and chemotherapy resistance in pancreatic cancer: bioinformatics and experimental analysis.
Zheng X, Du Y, Liu M, Wang C. Zheng X, et al. Funct Integr Genomics. 2023 Jun 4;23(2):196. doi: 10.1007/s10142-023-01122-z. Funct Integr Genomics. 2023. Retraction in: Funct Integr Genomics. 2024 May 11;24(3):86. doi: 10.1007/s10142-024-01373-4. PMID: 37270717 Free PMC article. Retracted.
After constructing a three-gene (TMEM80, EIF4EBP1, and ITGA3) purity-independent Cox regression model using machine learning, ITGA3 was identified as a critical integrin subunit gene in pancreatic cancer. ITGA3 is involved in the molecular transformation from …
After constructing a three-gene (TMEM80, EIF4EBP1, and ITGA3) purity-independent Cox regression model using machine learning, ITGA …
Evaluation of ITGA3 as a Biomarker of Progression and Recurrence in Papillary Thyroid Carcinoma.
Zhang G, Li B, Lin Y. Zhang G, et al. Front Oncol. 2022 Jan 31;11:614955. doi: 10.3389/fonc.2021.614955. eCollection 2021. Front Oncol. 2022. PMID: 35174063 Free PMC article.

Survival analysis showed that patients with high expression of ITGA3 in PTC had a poorer relapse-free survival (RFS) than patients with low expression of ITGA3 (P < 0.05). ...High expression of ITGA3 may have the potential role of predicting PTC recurrence

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Survival analysis showed that patients with high expression of ITGA3 in PTC had a poorer relapse-free survival (RFS) than patients wi …
ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer.
Li Y, Li F, Bai X, Li Y, Ni C, Zhao X, Zhang D. Li Y, et al. Front Oncol. 2021 May 20;11:658547. doi: 10.3389/fonc.2021.658547. eCollection 2021. Front Oncol. 2021. PMID: 34094951 Free PMC article.
High expression of ITGA3 was associated with better prognosis of breast cancer patients. ROC analysis indicated that ITGA3 had significant diagnostic value. Genomic analysis revealed that promoter methylation of ITGA3 leads to transcriptional silencing, which …
High expression of ITGA3 was associated with better prognosis of breast cancer patients. ROC analysis indicated that ITGA3 had …
Detection of bladder cancer with aberrantly fucosylated ITGA3.
Islam MK, Syed P, Dhondt B, Gidwani K, Pettersson K, Lamminmäki U, Leivo J. Islam MK, et al. Anal Biochem. 2021 Sep 1;628:114283. doi: 10.1016/j.ab.2021.114283. Epub 2021 Jun 5. Anal Biochem. 2021. PMID: 34102169 Free article.
We describe a simple, non-invasive assay to identify fucosylated-glycoisoform of integrin alpha-3 (ITGA3) directly from unprocessed urine. ITGA3 was detected directly from the urine of bladder cancer (BlCa) (n = 13) and benign prostatic hyperplasia (BPH) (n = 9) pat …
We describe a simple, non-invasive assay to identify fucosylated-glycoisoform of integrin alpha-3 (ITGA3) directly from unprocessed u …
301 results