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108 results

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Page 1
Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial.
Loo C, Glozier N, Barton D, Baune BT, Mills NT, Fitzgerald P, Glue P, Sarma S, Galvez-Ortiz V, Hadzi-Pavlovic D, Alonzo A, Dong V, Martin D, Nikolin S, Mitchell PB, Berk M, Carter G, Hackett M, Leyden J, Hood S, Somogyi AA, Lapidus K, Stratton E, Gainsford K, Garg D, Thornton NLR, Fourrier C, Richardson K, Rozakis D, Scaria A, Mihalopoulos C, Chatterton ML, McDonald WM, Boyce P, Holtzheimer PE, Kozel FA, Riva-Posse P, Rodgers A. Loo C, et al. Br J Psychiatry. 2023 Dec;223(6):533-541. doi: 10.1192/bjp.2023.79. Br J Psychiatry. 2023. PMID: 38108319 Free PMC article. Clinical Trial.
Erratum for the Technical Comment "Comment on 'Principles of connectivity among morphologically defined cell types in adult neocortex'" by A. L. Barth, A. Burkhalter, E. M. Callaway, B. W. Connors, B. Cauli, J. DeFelipe, D. Feldmeyer, T. Freund, Y. Kawaguchi, Z. Kisvarday, Y. Kubota, C. McBain, M. Oberlaender, J. Rossier, B. Rudy, J. F. Staiger, P. Somogyi, G. Tamas, R. Yuste.
[No authors listed] [No authors listed] Science. 2016 Sep 23;353(6306):aaj2094. doi: 10.1126/science.aaj2094. Science. 2016. PMID: 27708009 No abstract available.
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.
Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators. Ridker PM, et al. N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17. N Engl J Med. 2017. PMID: 28304242 Free article. Clinical Trial.
Tacrolimus dose, blood concentrations and acute nephrotoxicity, but not CYP3A5/ABCB1 genetics, are associated with allograft tacrolimus concentrations in renal transplant recipients.
Sallustio BC, Noll BD, Hu R, Barratt DT, Tuke J, Coller JK, Russ GR, Somogyi AA. Sallustio BC, et al. Br J Clin Pharmacol. 2021 Oct;87(10):3901-3909. doi: 10.1111/bcp.14806. Epub 2021 Mar 19. Br J Clin Pharmacol. 2021. PMID: 33646566 Free article.
RESULTS: C(0Blood) ranged from 2.6 to 52.3 ng/mL and C(Graft) from 33 to 828 pg/mg tissue. Adjusting for dose, recipients who were CYP3A5 expressors had lower C(0Blood) compared to nonexpressors, whilst delayed graft function was associated with higher C …
RESULTS: C(0Blood) ranged from 2.6 to 52.3 ng/mL and C(Graft) from 33 to 828 pg/mg tissue. Adjusting for dose, recipients who …
Euphane and Tirucallane Triterpenes with Trypanocidal Activity from Euphorbia desmondii.
Saidu MB, Krstić G, Barta A, Hunyadi A, Berkecz R, Gallah US, Cholke K, Gertsch J, Rédei D, Hohmann J. Saidu MB, et al. J Nat Prod. 2024 Sep 27;87(9):2281-2291. doi: 10.1021/acs.jnatprod.4c00730. Epub 2024 Sep 14. J Nat Prod. 2024. PMID: 39276089 Free PMC article.
The phytochemical investigation of Euphorbia desmondii resulted in the isolation of 15 previously undescribed triterpenoids (desmondiins A, C-P) and 8 already described compounds. The structures of the isolated compounds were determined by extensive spectroscopic analyses. …
The phytochemical investigation of Euphorbia desmondii resulted in the isolation of 15 previously undescribed triterpenoids (desmondiins A, …
Ingol, ent-atisane, and stachane-type diterpenoids from Euphorbia deightonii with multidrug resistance reversing activity.
Saidu MB, Kúsz N, Berkecz R, Rácz B, Spengler G, Hohmann J, Rédei D. Saidu MB, et al. Phytochemistry. 2022 Dec;204:113344. doi: 10.1016/j.phytochem.2022.113344. Epub 2022 Aug 8. Phytochemistry. 2022. PMID: 35952771
The structures were established by extensive spectroscopic analysis involving 1D ((1)H, (13)C J-modulation) and 2D NMR experiments, HRESIMS measurements, and the comparison of the spectroscopic data with reported literature values. ...
The structures were established by extensive spectroscopic analysis involving 1D ((1)H, (13)C J-modulation) and 2D NMR experim …
Interactions of Hsp90 with histones and related peptides.
Schnaider T, Oikarinen J, Ishiwatari-Hayasaka H, Yahara I, Csermely P. Schnaider T, et al. Life Sci. 1999;65(22):2417-26. doi: 10.1016/s0024-3205(99)00508-1. Life Sci. 1999. PMID: 10597896
The 90 kDa heat shock protein (Hsp90) induces the condensation of the chromatin structure [Csermely, P., Kajtar, J., Hollosi, M., Oikarinen, J., and Somogyi, J. (1994) Biochem. Biophys. Res. Commun. 202, 1657-1663]. In our present studies we used surfa …
The 90 kDa heat shock protein (Hsp90) induces the condensation of the chromatin structure [Csermely, P., Kajtar, J., Hollosi, M., Oik …
Effects of Low-Dose and Very Low-Dose Ketamine among Patients with Major Depression: a Systematic Review and Meta-Analysis.
Xu Y, Hackett M, Carter G, Loo C, Gálvez V, Glozier N, Glue P, Lapidus K, McGirr A, Somogyi AA, Mitchell PB, Rodgers A. Xu Y, et al. Int J Neuropsychopharmacol. 2016 Apr 20;19(4):pyv124. doi: 10.1093/ijnp/pyv124. Print 2016 Apr. Int J Neuropsychopharmacol. 2016. PMID: 26578082 Free PMC article. Review.
Six trials assessed low-dose ketamine (0.5 mg/kg i.v.) and 3 tested very low-dose ketamine (one trial assessed 50 mg intra-nasal spray, another assessed 0.1-0.4 mg/kg i.v., and another assessed 0.1-0.5 mg/kg i.v., intramuscular, or s.c.). At day 3, the reduction in depress …
Six trials assessed low-dose ketamine (0.5 mg/kg i.v.) and 3 tested very low-dose ketamine (one trial assessed 50 mg intra-nasal spray, anot …
Biocompatible poly(ethylene succinate) polyester with molecular weight dependent drug release properties.
Abdelghafour MM, Orbán Á, Deák Á, Lamch Ł, Frank É, Nagy R, Ziegenheim S, Sipos P, Farkas E, Bari F, Janovák L. Abdelghafour MM, et al. Int J Pharm. 2022 Apr 25;618:121653. doi: 10.1016/j.ijpharm.2022.121653. Epub 2022 Mar 9. Int J Pharm. 2022. PMID: 35278604
To prove this, poly(ethylene succinate) (PES) polyesters with polycondensation time regulated molecular weights were synthesized via catalyst-free direct polymerization in an equimolar ratio of ethylene glycol and succinic acid monomers at 185 C. DSC and contact angle meas …
To prove this, poly(ethylene succinate) (PES) polyesters with polycondensation time regulated molecular weights were synthesized via catalys …
Zfp206 regulates ES cell gene expression and differentiation.
Zhang W, Walker E, Tamplin OJ, Rossant J, Stanford WL, Hughes TR. Zhang W, et al. Nucleic Acids Res. 2006;34(17):4780-90. doi: 10.1093/nar/gkl631. Epub 2006 Sep 13. Nucleic Acids Res. 2006. PMID: 16971461 Free PMC article.
Expression surveys suggest that the putative SCAN-Zinc finger transcription factor Zfp206 is expressed specifically in ES cells [Zhang,W., Morris,Q.D., Chang,R., Shai,O., Bakowski,M.A., Mitsakakis,N., Mohammad,N., Robinson,M.D., Zirngibl,R., Somogyi,E. et al., (2004) J …
Expression surveys suggest that the putative SCAN-Zinc finger transcription factor Zfp206 is expressed specifically in ES cells [Zhang,W., M …
108 results