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121 results

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Page 1
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG. Anastasiou D, et al. Nat Chem Biol. 2012 Oct;8(10):839-47. doi: 10.1038/nchembio.1060. Nat Chem Biol. 2012. PMID: 22922757 Free PMC article.
Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development.
Jordan R, Ford-Scheimer SL, Alarcon RM, Atala A, Borenstein JT, Brimacombe KR, Cherry S, Clevers H, Davis MI, Funnell SGP, Gehrke L, Griffith LG, Grossman AC, Hartung T, Ingber DE, Kleinstreuer NC, Kuo CJ, Lee EM, Mummery CL, Pickett TE, Ramani S, Rosado-Olivieri EA, Struble EB, Wan Z, Williams MS, Hall MD, Ferrer M, Markossian S. Jordan R, et al. J Infect Dis. 2023 Oct 3;228(Suppl 5):S337-S354. doi: 10.1093/infdis/jiad334. J Infect Dis. 2023. PMID: 37669225 Free PMC article.
A quantitative model of the Escherichia coli 16 S RNA in the 30 S ribosomal subunit.
Malhotra A, Harvey SC. Malhotra A, et al. J Mol Biol. 1994 Jul 22;240(4):308-40. doi: 10.1006/jmbi.1994.1448. J Mol Biol. 1994. PMID: 7518524
Our models are based on the 16 S RNA secondary structure, the small angle neutron scatter map of 30 S proteins, tertiary RNA-RNA and RNA-protein contacts as suggested by cross-linking, chemical footprinting and other experimental studies, and electron microscopy dat …
Our models are based on the 16 S RNA secondary structure, the small angle neutron scatter map of 30 S proteins, tertiary RNA-R …
The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution.
Mueller F, Sommer I, Baranov P, Matadeen R, Stoldt M, Wöhnert J, Görlach M, van Heel M, Brimacombe R. Mueller F, et al. J Mol Biol. 2000 Apr 21;298(1):35-59. doi: 10.1006/jmbi.2000.3635. J Mol Biol. 2000. PMID: 10756104
The Escherichia coli 23 S and 5 S rRNA molecules have been fitted helix by helix to a cryo-electron microscopic (EM) reconstruction of the 50 S ribosomal subunit, using an unfiltered version of the recently published 50 S reconstruction at 7.5 A resolu …
The Escherichia coli 23 S and 5 S rRNA molecules have been fitted helix by helix to a cryo-electron microscopic (EM) reconstru …
Solution scattering structural analysis of the 70 S Escherichia coli ribosome by contrast variation. I. Invariants and validation of electron microscopy models.
Svergun DI, Burkhardt N, Pedersen JS, Koch MH, Volkov VV, Kozin MB, Meerwink W, Stuhrmann HB, Diedrich G, Nierhaus KH. Svergun DI, et al. J Mol Biol. 1997 Aug 29;271(4):588-601. doi: 10.1006/jmbi.1997.1190. J Mol Biol. 1997. PMID: 9281427
The data allow an experimental validation of the two most recent electron microscopy reconstructions of the 70 S ribosome presented by the groups of J. Frank (Albany) and of M. van Heel & R. Brimacombe (Berlin). ...For the 50 S subunit of van Heel …
The data allow an experimental validation of the two most recent electron microscopy reconstructions of the 70 S ribosome presented b …
Fresh frozen plasma and cryoprecipitate: Can we safely reduce their use in the NICU?
Sarkar S, Brimacombe M, Herson V. Sarkar S, et al. J Perinatol. 2023 Feb;43(2):226-230. doi: 10.1038/s41372-022-01438-x. Epub 2022 Jul 4. J Perinatol. 2023. PMID: 35789197
Charts of neonates admitted between 1/1/2010 to 12/31/2017 to CT Children's level 4 NICU were reviewed. Transfusions were assigned as "supported" or "non-supported" based on available evidence. ...
Charts of neonates admitted between 1/1/2010 to 12/31/2017 to CT Children's level 4 NICU were reviewed. Transfusions were assigned as …
Distribution of cross-links between mRNA analogues and 16 S rRNA in Escherichia coli 70 S ribosomes made under equilibrium conditions and their response to tRNA binding.
Juzumiene DI, Shapkina TG, Wollenzien P. Juzumiene DI, et al. J Biol Chem. 1995 May 26;270(21):12794-800. doi: 10.1074/jbc.270.21.12794. J Biol Chem. 1995. PMID: 7759534 Free article.
The sequences of the mRNA analogues were described earlier (Stade, K., Rinke-Appel, J., and Brimacombe, R. (1989) Nucleic Acids Res. 17, 9889-9908; Rinke-Appel, J., Stade, K., and Brimacombe, R. (1991) EMBO J. 10, 2195-2202). ...Three other cros …
The sequences of the mRNA analogues were described earlier (Stade, K., Rinke-Appel, J., and Brimacombe, R. (1989) Nucleic Acid …
Solution scattering structural analysis of the 70 S Escherichia coli ribosome by contrast variation. II. A model of the ribosome and its RNA at 3.5 nm resolution.
Svergun DI, Burkhardt N, Pedersen JS, Koch MH, Volkov VV, Kozin MB, Meerwink W, Stuhrmann HB, Diedrich G, Nierhaus KH. Svergun DI, et al. J Mol Biol. 1997 Aug 29;271(4):602-18. doi: 10.1006/jmbi.1997.1191. J Mol Biol. 1997. PMID: 9281428
Selectively deuterated 70 S E. coli ribosomes and isolated 30 S and 50 S subunits were analyzed by X-ray and neutron solution scattering. ...Brimacombe (Berlin). The rRNA moiety in the 30 S subunit is more anisometric than the subunit itself, wh …
Selectively deuterated 70 S E. coli ribosomes and isolated 30 S and 50 S subunits were analyzed by X-ray and neutron so …
121 results