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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 7
1995 47
1996 57
1997 47
1998 49
1999 55
2000 59
2001 67
2002 67
2003 18
2004 12
2005 6
2006 34
2007 49
2008 69
2009 36
2010 64
2011 109
2012 114
2013 47
2014 40
2015 87
2016 52
2017 24
2018 49
2019 39
2020 64
2021 35
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1,347 results
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Page 1
Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets.
Izzo A, Mollo N, Nitti M, Paladino S, Calì G, Genesio R, Bonfiglio F, Cicatiello R, Barbato M, Sarnataro V, Conti A, Nitsch L. Izzo A, et al. Mol Med. 2018 Mar 15;24(1):2. doi: 10.1186/s10020-018-0004-y. Mol Med. 2018. PMID: 30134785 Free PMC article. Review.
In this short review we first provide a basic overview of mitochondrial phenotype in DS cells and tissues. We then discuss how specific Hsa21 genes may be involved in determining the disruption of mitochondrial DS phenotype and biogenesis. ...
In this short review we first provide a basic overview of mitochondrial phenotype in DS cells and tissues. We then discuss how specif …
Zinc in human health: effect of zinc on immune cells.
Prasad AS. Prasad AS. Mol Med. 2008 May-Jun;14(5-6):353-7. doi: 10.2119/2008-00033.Prasad. Mol Med. 2008. PMID: 18385818 Free PMC article. Review.
In our studies in an experimental human model of zinc deficiency, we documented decreased serum testosterone level, oligospermia, severe immune dysfunctions mainly affecting T helper cells, hyperammonemia, neurosensory disorders, and decreased lean body mass. ...The therap …
In our studies in an experimental human model of zinc deficiency, we documented decreased serum testosterone level, oligospermia, severe imm …
Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis.
Yang J, Pan X, Wang L, Yu G. Yang J, et al. Mol Med. 2020 Oct 14;26(1):95. doi: 10.1186/s10020-020-00223-w. Mol Med. 2020. PMID: 33054759 Free PMC article. Review.
However, increasing mechanical stress likely exists before the establishment of fibrosis since early micro injuries increase local vascular permeability and prompt cytoskeletal remodeling which alter cellular mechanical forces. It is noteworthy that COVID-19 patients with …
However, increasing mechanical stress likely exists before the establishment of fibrosis since early micro injuries increase local vascular …
High co-expression of TNF-α and CARDS toxin is a good predictor for refractory Mycoplasma pneumoniae pneumonia.
Li G, Fan L, Wang Y, Huang L, Wang M, Zhu C, Hao C, Ji W, Liang H, Yan Y, Chen Z. Li G, et al. Mol Med. 2019 Aug 9;25(1):38. doi: 10.1186/s10020-019-0105-2. Mol Med. 2019. PMID: 31399022 Free PMC article.
The recombinant CARDS toxin was constructed and prepared at different concentrations for stimulation of RAW264.7 cells. After co-culture with CARDS toxin, cytokines were detected by ELISA and the mRNA levels were measured by real-time PCR. ...
The recombinant CARDS toxin was constructed and prepared at different concentrations for stimulation of RAW264.7 cells. After co-cult …
Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation.
Yang H, Liu H, Zeng Q, Imperato GH, Addorisio ME, Li J, He M, Cheng KF, Al-Abed Y, Harris HE, Chavan SS, Andersson U, Tracey KJ. Yang H, et al. Mol Med. 2019 Apr 11;25(1):13. doi: 10.1186/s10020-019-0081-6. Mol Med. 2019. PMID: 30975096 Free PMC article.
The aim of the study was to identify molecules inhibiting HMGB1 or HMGB1/LPS cellular internalization. METHODS: Endocytosis was studied in cultured macrophages using Alexa Fluor-labeled HMGB1 or complexes of HMGB1 and Alexa Fluor-labeled LPS in the presence of an anti-HMGB …
The aim of the study was to identify molecules inhibiting HMGB1 or HMGB1/LPS cellular internalization. METHODS: Endocytosis was studi …
Disorders of FZ-CRD; insights towards FZ-CRD folding and therapeutic landscape.
Milhem RM, Ali BR. Milhem RM, et al. Mol Med. 2019 Dec 31;26(1):4. doi: 10.1186/s10020-019-0129-7. Mol Med. 2019. PMID: 31892318 Free PMC article. Review.
FZD4 and MuSK mutants were tagged with polyubiquitin chains confirming targeting for proteasomal degradation. Investigating the cellular and molecular mechanisms of these mutations is important since misfolded protein and ER-targeted therapies are in development. ...
FZD4 and MuSK mutants were tagged with polyubiquitin chains confirming targeting for proteasomal degradation. Investigating the cellular
Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers.
Itskovitz-Eldor J, Schuldiner M, Karsenti D, Eden A, Yanuka O, Amit M, Soreq H, Benvenisty N. Itskovitz-Eldor J, et al. Mol Med. 2000 Feb;6(2):88-95. Mol Med. 2000. PMID: 10859025 Free PMC article.
BACKGROUND: Embryonic stem (ES) cells are lines of cells that are isolated from blastocysts. The murine ES cells were demonstrated to be true pluripotent cells as they differentiate into all embryonic lineages. Yet, in vitro differentiation of rhesus E …
BACKGROUND: Embryonic stem (ES) cells are lines of cells that are isolated from blastocysts. The murine ES cells were d …
Inflammasome and autophagy regulation - a two-way street.
Sun Q, Fan J, Billiar TR, Scott MJ. Sun Q, et al. Mol Med. 2017 Sep;23:188-195. doi: 10.2119/molmed.2017.00077. Epub 2017 Jul 24. Mol Med. 2017. PMID: 28741645 Free PMC article. Review.
This then allows cleavage and activation of caspase-1, followed by downstream cleavage and release of proinflammatory cytokines, IL-1beta and IL-18, from innate immune cells. Hyperinflammation caused by unrestrained inflammasome activation is linked with multiple inflammat …
This then allows cleavage and activation of caspase-1, followed by downstream cleavage and release of proinflammatory cytokines, IL-1beta an …
Mechanism and regulation of cellular zinc transport.
Sekler I, Sensi SL, Hershfinkel M, Silverman WF. Sekler I, et al. Mol Med. 2007 Jul-Aug;13(7-8):337-43. doi: 10.2119/2007–00037.Sekler. Mol Med. 2007. PMID: 17622322 Free PMC article. Review.
Thus, the concentration of cellular zinc requires establishment of discrete, active cellular gradients. ...We will also highlight some of the unsolved issues regarding their role in cellular zinc homeostasis....
Thus, the concentration of cellular zinc requires establishment of discrete, active cellular gradients. ...We will also highli …
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