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Resveratrol and prostate cancer: promising role for microRNAs.
Dhar S, Hicks C, Levenson AS. Dhar S, et al. Mol Nutr Food Res. 2011 Aug;55(8):1219-29. doi: 10.1002/mnfr.201100141. Epub 2011 Jun 29. Mol Nutr Food Res. 2011. PMID: 21714127
Selected miRs were verified by qRT-PCR, including miR-17, miR-20a, miR-20b, miR-106a and miR106b. Since these miRNAs target PTEN (phosphatase and tensin homolog deleted on chromosome 10), we performed Western blot to confirm up-regulation of PTEN in PCa cells. ...
Selected miRs were verified by qRT-PCR, including miR-17, miR-20a, miR-20b, miR-106a and miR106b. Since these miRNAs target PTEN (pho …
Extracting material parameters from x-ray attenuation: a CT feasibility study using kilovoltage synchrotron x-rays incident upon low atomic number absorbers.
Kirby BJ, Davis JR, Grant JA, Morgan MJ. Kirby BJ, et al. Phys Med Biol. 2003 Oct 21;48(20):3389-409. doi: 10.1088/0031-9155/48/20/009. Phys Med Biol. 2003. PMID: 14620065
Computed tomography (CT) scans of small samples containing several liquids and solids were carried out with synchrotron radiation at the Australian National Beamline Facility (BL 20B) in Japan. Average values of the x-ray linear attenuation coefficient were extracted for e …
Computed tomography (CT) scans of small samples containing several liquids and solids were carried out with synchrotron radiation at the Aus …
Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.
Slater MJ, Amphlett EM, Andrews DM, Bravi G, Burton G, Cheasty AG, Corfield JA, Ellis MR, Fenwick RH, Fernandes S, Guidetti R, Haigh D, Hartley CD, Howes PD, Jackson DL, Jarvest RL, Lovegrove VL, Medhurst KJ, Parry NR, Price H, Shah P, Singh OM, Stocker R, Thommes P, Wilkinson C, Wonacott A. Slater MJ, et al. J Med Chem. 2007 Mar 8;50(5):897-900. doi: 10.1021/jm061207r. Epub 2007 Feb 2. J Med Chem. 2007. PMID: 17269759
Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties....
Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development cand …