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SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice.
Zhu J, Quizon PM, Wang Y, Adeniran CA, Strauss MJ, Jiménez-Torres AC, Patel P, Cirino TJ, Eans SO, Hammond HR, Deliscar LS, O'Hara P, Saini SK, Ofori E, Vekariya RH, Zhang S, Moukha-Chafiq O, Nguyen TH, Ananthan S, Augelli-Szafran CE, Zhan CG, McLaughlin JP. Zhu J, et al. Among authors: jimenez torres ac. Neuropharmacology. 2022 Dec 1;220:109239. doi: 10.1016/j.neuropharm.2022.109239. Epub 2022 Sep 17. Neuropharmacology. 2022. PMID: 36126727
Identification of pyrimidine structure-based compounds as allosteric ligands of the dopamine transporter as therapeutic agents for NeuroHIV.
Jimenez-Torres AC, Hastie JA, Davis SE, Porter KD, Lei B, Moukha-Chafiq O, Zhang S, Nguyen TH, Ananthan S, Augelli-Szafran CE, Zhu J. Jimenez-Torres AC, et al. J Pharmacol Exp Ther. 2024 Sep 16:JPET-AR-2024-002138. doi: 10.1124/jpet.124.002138. Online ahead of print. J Pharmacol Exp Ther. 2024. PMID: 39284625 Free article.