Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2016 3
2017 2
2018 1
2019 4
2020 3
2021 5
2022 2
2023 5
2024 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

25 results

Results by year

Filters applied: . Clear all
Page 1
JMJD8 Is an M2 Macrophage Biomarker, and It Associates With DNA Damage Repair to Facilitate Stemness Maintenance, Chemoresistance, and Immunosuppression in Pan-Cancer.
Liang X, Zhang H, Wang Z, Zhang X, Dai Z, Zhang J, Luo P, Zhang L, Hu J, Liu Z, Bi C, Cheng Q. Liang X, et al. Front Immunol. 2022 Jul 11;13:875786. doi: 10.3389/fimmu.2022.875786. eCollection 2022. Front Immunol. 2022. PMID: 35898493 Free PMC article.
RESULTS: We first noticed that JMJD8 was an oncogene in many cancer types. High JMJD8 was associated with lower genome stability. ...Finally, potential JMJD8-targeted drugs were screened out and docked to JMJD8 protein. CONCLUSION: We found that JMJ …
RESULTS: We first noticed that JMJD8 was an oncogene in many cancer types. High JMJD8 was associated with lower genome stabili …
ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer.
Yi J, Wang L, Du J, Wang M, Shen H, Liu Z, Qin Y, Liu J, Hu G, Xiao R, Ding J, Chen X, Wang H, Huang H, Ouyang G, Liu W. Yi J, et al. Dev Cell. 2023 May 8;58(9):760-778.e6. doi: 10.1016/j.devcel.2023.03.015. Epub 2023 Apr 12. Dev Cell. 2023. PMID: 37054705 Free article.
JMJD8 knockdown improves the efficacy of chemotherapy and immune checkpoint therapy in treating both human and mouse breast cancer cell-derived implanted tumors. ...Overall, our study found that JMJD8 regulates type I IFN responses, and targeting JMJD8 trigge …
JMJD8 knockdown improves the efficacy of chemotherapy and immune checkpoint therapy in treating both human and mouse breast cancer ce …
JMJD8 reduces cancer's STING.
VanHook AM. VanHook AM. Sci Signal. 2023 May 23;16(786):eadi7593. doi: 10.1126/scisignal.adi7593. Epub 2023 May 23. Sci Signal. 2023. PMID: 37220182
JMJD8 inhibits STING signaling and reduces antitumor responses....
JMJD8 inhibits STING signaling and reduces antitumor responses....
JMJD8 regulates neuropathic pain by affecting spinal cord astrocyte differentiation.
Li Y, Zhang Y, Zhou Z, Yi L, Ji F, Zhang K, Zhang Y, Xu H. Li Y, et al. Neurosci Lett. 2023 Jul 13;809:137307. doi: 10.1016/j.neulet.2023.137307. Epub 2023 May 19. Neurosci Lett. 2023. PMID: 37211325
Using a chronic constriction injury (CCI) mouse model of NP, we investigated the expression levels of JMJD8 during NP and the influences of JMJD8 on regulating pain sensitivity. We found that JMJD8 expression in the spinal dorsal horn was reduced after CCI. I …
Using a chronic constriction injury (CCI) mouse model of NP, we investigated the expression levels of JMJD8 during NP and the influen …
JMJD8 Functions as a Novel AKT1 Lysine Demethylase.
Wang Y, Zhang Y, Li Z, Wang J. Wang Y, et al. Int J Mol Sci. 2022 Dec 27;24(1):460. doi: 10.3390/ijms24010460. Int J Mol Sci. 2022. PMID: 36613903 Free PMC article.
JMJD8 is a protein from the JMJD family that only has the JmjC domain. Studies on the function of JMJD8 indicate that JMJD8 is involved in signaling pathways, including AKT/NF-kappaB, and thus affects cell proliferation and development. Here, we reported the …
JMJD8 is a protein from the JMJD family that only has the JmjC domain. Studies on the function of JMJD8 indicate that JMJD8 …
USP22-JMJD8 axis promotes Lenvatinib resistance in hepatocellular carcinoma.
Guo J, Zhao J. Guo J, et al. Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119617. doi: 10.1016/j.bbamcr.2023.119617. Epub 2023 Oct 26. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 37898375
More importantly, we found that USP22 and JMJD8 constitute a functional axis regulating the drug resistance of Lenvatinib in HCC. In the rescue experiment, the overexpression of JMJD8 could reduce the apoptosis induced by USP22 knockdown. In general, this study show …
More importantly, we found that USP22 and JMJD8 constitute a functional axis regulating the drug resistance of Lenvatinib in HCC. In …
JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance.
You D, Chul Jung B, Villivalam SD, Lim HW, Kang S. You D, et al. Diabetes. 2021 Oct 21:db210596. doi: 10.2337/db21-0596. Online ahead of print. Diabetes. 2021. PMID: 34957483
Adipose JMJD8 levels were dramatically increased in obesity-associated insulin resistance models. ...For this, JMJD8 required Interferon Regulatory Factor (IRF3) to mediate its actions in adipocytes. ...
Adipose JMJD8 levels were dramatically increased in obesity-associated insulin resistance models. ...For this, JMJD8 required …
JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance.
You D, Chul Jung B, Villivalam SD, Lim HW, Kang S. You D, et al. Diabetes. 2021 Oct 22;71(1):43-59. doi: 10.2337/db21-0596. Online ahead of print. Diabetes. 2021. PMID: 34686520 Free PMC article.
Adipose JMJD8 levels were dramatically increased in obesity-associated insulin resistance models. ...For this, JMJD8 required Interferon Regulatory Factor (IRF3) to mediate its actions in adipocytes. ...
Adipose JMJD8 levels were dramatically increased in obesity-associated insulin resistance models. ...For this, JMJD8 required …
JMJD8 Promotes Malignant Progression of Lung Cancer by Maintaining EGFR Stability and EGFR/PI3K/AKT Pathway Activation.
Zhang B, Zhang Y, Jiang X, Su H, Wang Q, Wudu M, Jiang J, Ren H, Xu Y, Liu Z, Qiu X. Zhang B, et al. J Cancer. 2021 Jan 1;12(4):976-987. doi: 10.7150/jca.50234. eCollection 2021. J Cancer. 2021. PMID: 33442397 Free PMC article.
The underlying biological functions and molecular mechanisms of JMJD8 in non-small-cell lung cancer (NSCLC) remain unclear. Herein, we explored the relationship between JMJD8 and the activation of malignancy pathways in NSCLC. ...Co-immunoprecipitation experiments i …
The underlying biological functions and molecular mechanisms of JMJD8 in non-small-cell lung cancer (NSCLC) remain unclear. Herein, w …
JMJD8 is a novel endoplasmic reticulum protein with a JmjC domain.
Yeo KS, Tan MC, Lim YY, Ea CK. Yeo KS, et al. Sci Rep. 2017 Nov 13;7(1):15407. doi: 10.1038/s41598-017-15676-z. Sci Rep. 2017. PMID: 29133832 Free PMC article.
Here, we employed bioinformatic analysis and immunofluorescence microscopy to examine the physiological properties of JMJD8. We demonstrated that JMJD8 localizes to the lumen of endoplasmic reticulum and that JMJD8 forms dimers or oligomers in vivo. Furthermo …
Here, we employed bioinformatic analysis and immunofluorescence microscopy to examine the physiological properties of JMJD8. We demon …
25 results