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Year Number of Results
2016 3
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2019 4
2020 3
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2025 3

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Page 1
JMJD8 reduces cancer's STING.
VanHook AM. VanHook AM. Sci Signal. 2023 May 23;16(786):eadi7593. doi: 10.1126/scisignal.adi7593. Epub 2023 May 23. Sci Signal. 2023. PMID: 37220182
JMJD8 inhibits STING signaling and reduces antitumor responses....
JMJD8 inhibits STING signaling and reduces antitumor responses....
JMJD8 regulates neuropathic pain by affecting spinal cord astrocyte differentiation.
Li Y, Zhang Y, Zhou Z, Yi L, Ji F, Zhang K, Zhang Y, Xu H. Li Y, et al. Neurosci Lett. 2023 Jul 13;809:137307. doi: 10.1016/j.neulet.2023.137307. Epub 2023 May 19. Neurosci Lett. 2023. PMID: 37211325
Using a chronic constriction injury (CCI) mouse model of NP, we investigated the expression levels of JMJD8 during NP and the influences of JMJD8 on regulating pain sensitivity. We found that JMJD8 expression in the spinal dorsal horn was reduced after CCI. I …
Using a chronic constriction injury (CCI) mouse model of NP, we investigated the expression levels of JMJD8 during NP and the influen …
JMJD8 Functions as a Novel AKT1 Lysine Demethylase.
Wang Y, Zhang Y, Li Z, Wang J. Wang Y, et al. Int J Mol Sci. 2022 Dec 27;24(1):460. doi: 10.3390/ijms24010460. Int J Mol Sci. 2022. PMID: 36613903 Free PMC article.
JMJD8 is a protein from the JMJD family that only has the JmjC domain. Studies on the function of JMJD8 indicate that JMJD8 is involved in signaling pathways, including AKT/NF-kappaB, and thus affects cell proliferation and development. Here, we reported the …
JMJD8 is a protein from the JMJD family that only has the JmjC domain. Studies on the function of JMJD8 indicate that JMJD8 …
JMJD8 Is an M2 Macrophage Biomarker, and It Associates With DNA Damage Repair to Facilitate Stemness Maintenance, Chemoresistance, and Immunosuppression in Pan-Cancer.
Liang X, Zhang H, Wang Z, Zhang X, Dai Z, Zhang J, Luo P, Zhang L, Hu J, Liu Z, Bi C, Cheng Q. Liang X, et al. Front Immunol. 2022 Jul 11;13:875786. doi: 10.3389/fimmu.2022.875786. eCollection 2022. Front Immunol. 2022. PMID: 35898493 Free PMC article.
RESULTS: We first noticed that JMJD8 was an oncogene in many cancer types. High JMJD8 was associated with lower genome stability. ...Finally, potential JMJD8-targeted drugs were screened out and docked to JMJD8 protein. CONCLUSION: We found that JMJ …
RESULTS: We first noticed that JMJD8 was an oncogene in many cancer types. High JMJD8 was associated with lower genome stabili …
JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance.
You D, Chul Jung B, Villivalam SD, Lim HW, Kang S. You D, et al. Diabetes. 2021 Oct 22;71(1):43-59. doi: 10.2337/db21-0596. Online ahead of print. Diabetes. 2021. PMID: 34686520 Free PMC article.
Adipose JMJD8 levels were dramatically increased in obesity-associated insulin resistance models. ...For this, JMJD8 required Interferon Regulatory Factor (IRF3) to mediate its actions in adipocytes. ...
Adipose JMJD8 levels were dramatically increased in obesity-associated insulin resistance models. ...For this, JMJD8 required …
JMJD8 Regulates Adipocyte Hypertrophy Through the Interaction With Perilipin 2.
You D, Kang S. You D, et al. Diabetes. 2025 Apr 1;74(4):458-471. doi: 10.2337/db23-0883. Diabetes. 2025. PMID: 39787420
New research builds on previous findings that JMJD8 mediates insulin resistance by promoting adipocyte hypertrophy. We identified PLIN2 as a binding partner of JMJD8 using proteomics approaches. ...JMJD8 suppresses fasting-induced lipophagy and reduces energy …
New research builds on previous findings that JMJD8 mediates insulin resistance by promoting adipocyte hypertrophy. We identified PLI …
JMJD8 Facilitates Hepatic Lipid Deposition and Metabolic Dysfunction.
You D, Ren H, Jung BC, Oh NY, Wang L, Maschek JA, Summers SA, Kang S. You D, et al. Am J Physiol Endocrinol Metab. 2025 Oct 29. doi: 10.1152/ajpendo.00328.2025. Online ahead of print. Am J Physiol Endocrinol Metab. 2025. PMID: 41159910 Free article.
To define the metabolic role of JMJD8 in the liver, we generated liver-specific Jmjd8 knockout (Jmjd8(LKO)) mice. Hepatic deletion of Jmjd8 reduced triglyceride (TG) accumulation under both dietary conditions, without affecting overall body weight or a …
To define the metabolic role of JMJD8 in the liver, we generated liver-specific Jmjd8 knockout (Jmjd8(LKO)) mice. Hepat …
JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance.
You D, Chul Jung B, Villivalam SD, Lim HW, Kang S. You D, et al. Diabetes. 2021 Oct 21:db210596. doi: 10.2337/db21-0596. Online ahead of print. Diabetes. 2021. PMID: 34957483
Adipose JMJD8 levels were dramatically increased in obesity-associated insulin resistance models. ...For this, JMJD8 required Interferon Regulatory Factor (IRF3) to mediate its actions in adipocytes. ...
Adipose JMJD8 levels were dramatically increased in obesity-associated insulin resistance models. ...For this, JMJD8 required …
JMJD8 Promotes Malignant Progression of Lung Cancer by Maintaining EGFR Stability and EGFR/PI3K/AKT Pathway Activation.
Zhang B, Zhang Y, Jiang X, Su H, Wang Q, Wudu M, Jiang J, Ren H, Xu Y, Liu Z, Qiu X. Zhang B, et al. J Cancer. 2021 Jan 1;12(4):976-987. doi: 10.7150/jca.50234. eCollection 2021. J Cancer. 2021. PMID: 33442397 Free PMC article.
The underlying biological functions and molecular mechanisms of JMJD8 in non-small-cell lung cancer (NSCLC) remain unclear. Herein, we explored the relationship between JMJD8 and the activation of malignancy pathways in NSCLC. ...Co-immunoprecipitation experiments i …
The underlying biological functions and molecular mechanisms of JMJD8 in non-small-cell lung cancer (NSCLC) remain unclear. Herein, w …
USP22-JMJD8 axis promotes Lenvatinib resistance in hepatocellular carcinoma.
Guo J, Zhao J. Guo J, et al. Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119617. doi: 10.1016/j.bbamcr.2023.119617. Epub 2023 Oct 26. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 37898375 Free article.
More importantly, we found that USP22 and JMJD8 constitute a functional axis regulating the drug resistance of Lenvatinib in HCC. In the rescue experiment, the overexpression of JMJD8 could reduce the apoptosis induced by USP22 knockdown. In general, this study show …
More importantly, we found that USP22 and JMJD8 constitute a functional axis regulating the drug resistance of Lenvatinib in HCC. In …
28 results