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Page 1
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.
Thomas T, Friedrich M, Rich-Griffin C, Pohin M, Agarwal D, Pakpoor J, Lee C, Tandon R, Rendek A, Aschenbrenner D, Jainarayanan A, Voda A, Siu JHY, Sanches-Peres R, Nee E, Sathananthan D, Kotliar D, Todd P, Kiourlappou M, Gartner L, Ilott N, Issa F, Hester J, Turner J, Nayar S, Mackerodt J, Zhang F, Jonsson A, Brenner M, Raychaudhuri S, Kulicke R, Ramsdell D, Stransky N, Pagliarini R, Bielecki P, Spies N, Marsden B, Taylor S, Wagner A, Klenerman P, Walsh A, Coles M, Jostins-Dean L, Powrie FM, Filer A, Travis S, Uhlig HH, Dendrou CA, Buckley CD. Thomas T, et al. Among authors: jostins dean l. Nat Immunol. 2024 Nov;25(11):2152-2165. doi: 10.1038/s41590-024-01994-8. Epub 2024 Oct 22. Nat Immunol. 2024. PMID: 39438660 Free PMC article.
Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.
Ryzhakov G, Almuttaqi H, Corbin AL, Berthold DL, Khoyratty T, Eames HL, Bullers S, Pearson C, Ai Z, Zec K, Bonham S, Fischer R, Jostins-Dean L, Travis SPL, Kessler BM, Udalova IA. Ryzhakov G, et al. Among authors: jostins dean l. Nat Commun. 2021 Nov 18;12(1):6702. doi: 10.1038/s41467-021-27038-5. Nat Commun. 2021. PMID: 34795257 Free PMC article.
Defining predictors of responsiveness to advanced therapies in Crohn's disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine.
Wyatt NJ, Watson H, Anderson CA, Kennedy NA, Raine T, Ahmad T, Allerton D, Bardgett M, Clark E, Clewes D, Cotobal Martin C, Doona M, Doyle JA, Frith K, Hancock HC, Hart AL, Hildreth V, Irving PM, Iqbal S, Kennedy C, King A, Lawrence S, Lees CW, Lees R, Letchford L, Liddle T, Lindsay JO, Maier RH, Mansfield JC, Marchesi JR, McGregor N, McIntyre RE, Ostermayer J, Osunnuyi T, Powell N, Prescott NJ, Satsangi J, Sharma S, Shrestha T, Speight A, Strickland M, Wason JM, Whelan K, Wood R, Young GR, Zhang X, Parkes M, Stewart CJ, Jostins-Dean L, Lamb CA. Wyatt NJ, et al. Among authors: jostins dean l. BMJ Open. 2024 Apr 17;14(4):e073639. doi: 10.1136/bmjopen-2023-073639. BMJ Open. 2024. PMID: 38631839 Free PMC article.
Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background.
Zhang C, Shestopaloff K, Hollis B, Kwok CH, Hon C, Hartmann N, Tian C, Wozniak M, Santos L, West D, Gardiner S, Mallon AM, Readie A, Martin R, Nichols T, Beste MT, Zierer J, Ferrero E, Vandemeulebroecke M, Jostins-Dean L. Zhang C, et al. Among authors: jostins dean l. Am J Hum Genet. 2023 Oct 5;110(10):1817-1824. doi: 10.1016/j.ajhg.2023.08.010. Epub 2023 Sep 1. Am J Hum Genet. 2023. PMID: 37659414 Free PMC article.
Considerations for peripheral blood transport and storage during large-scale multicentre metabolome research.
Alexander JL, Wyatt NJ, Camuzeaux S, Chekmeneva E, Jimenez B, Sands CJ, Fuller H, Takis P, Ahmad T, Doyle JA, Hart A, Irving PM, Kennedy NA, Lees CW, Lindsay JO, McIntyre RE, Parkes M, Prescott NJ, Raine T, Satsangi J, Speight RA, Jostins-Dean L, Powell N, Marchesi JR, Stewart CJ, Lamb CA. Alexander JL, et al. Among authors: jostins dean l. Gut. 2024 Jan 5;73(2):379-383. doi: 10.1136/gutjnl-2022-329297. Gut. 2024. PMID: 36754608 Free PMC article. No abstract available.
Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank.
Hollis B, Chatzigeorgiou C, Southam L, Hatzikotoulas K, Kluzek S, Williams A; Genetics of Osteoarthritis Consortium; Zeggini E, Jostins-Dean L, Watt FE. Hollis B, et al. Among authors: jostins dean l. Osteoarthritis Cartilage. 2023 Oct;31(10):1377-1387. doi: 10.1016/j.joca.2023.05.012. Epub 2023 May 27. Osteoarthritis Cartilage. 2023. PMID: 37247657 Free article.
Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2.
Mukhopadhyay S, Heinz E, Porreca I, Alasoo K, Yeung A, Yang HT, Schwerd T, Forbester JL, Hale C, Agu CA, Choi YH, Rodrigues J, Capitani M, Jostins-Dean L, Thomas DC, Travis S, Gaffney D, Skarnes WC, Thomson N, Uhlig HH, Dougan G, Powrie F. Mukhopadhyay S, et al. Among authors: jostins dean l. J Exp Med. 2020 Feb 3;217(2):e20180649. doi: 10.1084/jem.20180649. J Exp Med. 2020. PMID: 31819956 Free PMC article.
Development of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium.
Deng Y, Perry TA, Hulley P, Maciewicz RA, Mitchelmore J, Perry D, Larsson S, Brachat S, Struglics A, Appleton CT, Kluzek S, Arden NK, Felson D, Marsden B, Tom BDM, Bondi L, Kapoor M, Batchelor V, Mackay-Alderson J, Kumar V, Lohmander LS, Welting TJ, Walsh DA, Valdes AM; STEpUP OA Consortium; Vincent TL, Watt FE, Jostins-Dean L. Deng Y, et al. Among authors: jostins dean l. PLoS One. 2024 Nov 18;19(11):e0309677. doi: 10.1371/journal.pone.0309677. eCollection 2024. PLoS One. 2024. PMID: 39556578 Free PMC article.