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Tumor microenvironment evaluation promotes precise checkpoint immunotherapy of advanced gastric cancer.

Zeng D, Wu J, Luo H, Li Y, Xiao J, Peng J, Ye Z, Zhou R, Yu Y, Wang G, Huang N, Wu J, Rong X, Sun L, Sun H, Qiu W, Xue Y, Bin J, Liao Y, Li N, Shi M, Kim KM, Liao W. Zeng D, et al. J Immunother Cancer. 2021 Aug;9(8):e002467. doi: 10.1136/jitc-2021-002467. J Immunother Cancer. 2021. PMID: 34376552 Free PMC article. Clinical Trial.

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Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma.

Greten TF, Abou-Alfa GK, Cheng AL, Duffy AG, El-Khoueiry AB, Finn RS, Galle PR, Goyal L, He AR, Kaseb AO, Kelley RK, Lencioni R, Lujambio A, Mabry Hrones D, Pinato DJ, Sangro B, Troisi RI, Wilson Woods A, Yau T, Zhu AX, Melero I. Greten TF, et al. J Immunother Cancer. 2021 Sep;9(9):e002794. doi: 10.1136/jitc-2021-002794. J Immunother Cancer. 2021. PMID: 34518290 Free PMC article.

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Neoadjuvant immunotherapy for non-small cell lung cancer: right drugs, right patient, right time?

Ahern E, Solomon BJ, Hui R, Pavlakis N, O'Byrne K, Hughes BGM. Ahern E, et al. J Immunother Cancer. 2021 Jun;9(6):e002248. doi: 10.1136/jitc-2020-002248. J Immunother Cancer. 2021. PMID: 34083418 Free PMC article. Review.

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THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.

Li C, Chi H, Deng S, Wang H, Yao H, Wang Y, Chen D, Guo X, Fang JY, He F, Xu J. Li C, et al. J Immunother Cancer. 2021 Aug;9(8):e002443. doi: 10.1136/jitc-2021-002443. J Immunother Cancer. 2021. PMID: 34341130 Free PMC article.

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Trans-arterial chemoembolization as a loco-regional inducer of immunogenic cell death in hepatocellular carcinoma: implications for immunotherapy.

Pinato DJ, Murray SM, Forner A, Kaneko T, Fessas P, Toniutto P, Mínguez B, Cacciato V, Avellini C, Diaz A, Boyton RJ, Altmann DM, Goldin RD, Akarca AU, Marafioti T, Mauri FA, Casagrande E, Grillo F, Giannini E, Bhoori S, Mazzaferro V. Pinato DJ, et al. J Immunother Cancer. 2021 Sep;9(9):e003311. doi: 10.1136/jitc-2021-003311. J Immunother Cancer. 2021. PMID: 34593621 Free PMC article.

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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design.

Qin H, Yang L, Chukinas JA, Shah N, Tarun S, Pouzolles M, Chien CD, Niswander LM, Welch AR, Taylor N, Tasian SK, Fry TJ. Qin H, et al. J Immunother Cancer. 2021 Sep;9(9):e003149. doi: 10.1136/jitc-2021-003149. J Immunother Cancer. 2021. PMID: 34531250 Free PMC article.

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CXCR6 is required for antitumor efficacy of intratumoral CD8⁺ T cell.

Wang B, Wang Y, Sun X, Deng G, Huang W, Wu X, Gu Y, Tian Z, Fan Z, Xu Q, Chen H, Sun Y. Wang B, et al. J Immunother Cancer. 2021 Aug;9(8):e003100. doi: 10.1136/jitc-2021-003100. J Immunother Cancer. 2021. PMID: 34462326 Free PMC article.

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Genomic alterations in biliary tract cancer predict prognosis and immunotherapy outcomes.

Chen X, Wang D, Liu J, Qiu J, Zhou J, Ying J, Shi Y, Wang Z, Lou H, Cui J, Zhang J, Liu Y, Zhao F, Pan L, Zhao J, Zhu D, Chen S, Li X, Li X, Zhu L, Shao Y, Shu Y. Chen X, et al. J Immunother Cancer. 2021 Nov;9(11):e003214. doi: 10.1136/jitc-2021-003214. J Immunother Cancer. 2021. PMID: 34795005 Free PMC article.

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Deregulation of HLA-I in cancer and its central importance for immunotherapy.

Hazini A, Fisher K, Seymour L. Hazini A, et al. J Immunother Cancer. 2021 Aug;9(8):e002899. doi: 10.1136/jitc-2021-002899. J Immunother Cancer. 2021. PMID: 34353849 Free PMC article. Review.

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PD-L2 glycosylation promotes immune evasion and predicts anti-EGFR efficacy.

Xu Y, Gao Z, Hu R, Wang Y, Wang Y, Su Z, Zhang X, Yang J, Mei M, Ren Y, Li M, Zhou X. Xu Y, et al. J Immunother Cancer. 2021 Oct;9(10):e002699. doi: 10.1136/jitc-2021-002699. J Immunother Cancer. 2021. PMID: 34697216 Free PMC article.

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