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Methadone Blockade of Cardiac Inward Rectifier K(+) Current Augments Membrane Instability and Amplifies U Waves on Surface ECGs: A Translational Study.
Klein MG, Krantz MJ, Fatima N, Watters A, Colon-Sanchez D, Geiger RM, Goldstein RE, Solhjoo S, Mehler PS, Flagg TP, Haigney MC. Klein MG, et al. J Am Heart Assoc. 2022 Jun 7;11(11):e023482. doi: 10.1161/JAHA.121.023482. Epub 2022 Jun 6. J Am Heart Assoc. 2022. PMID: 35658478 Free PMC article.
Background Methadone is associated with a disproportionate risk of sudden death and ventricular tachyarrhythmia despite only modest inhibition of delayed rectifier K(+) current (I(Kr))(,) the principal mechanism of drug-associated arrhythmia. Congenital defects of inward r …
Background Methadone is associated with a disproportionate risk of sudden death and ventricular tachyarrhythmia despite only modest inhibiti …
Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis.
Zhou L, Solhjoo S, Millare B, Plank G, Abraham MR, Cortassa S, Trayanova N, O'Rourke B. Zhou L, et al. Circ Arrhythm Electrophysiol. 2014 Feb;7(1):143-51. doi: 10.1161/CIRCEP.113.000600. Epub 2014 Jan 1. Circ Arrhythm Electrophysiol. 2014. PMID: 24382411 Free PMC article.
It has been proposed that the formation of metabolic current sinks, caused by the nonuniform collapse of mitochondrial inner membrane potential (deltapsim), contributes to re-entrant arrhythmias because deltapsim depolarization is tightly coupled to the activation of sarcolemmal …
It has been proposed that the formation of metabolic current sinks, caused by the nonuniform collapse of mitochondrial inner membrane potent …
Role of suppression of the inward rectifier current in terminal action potential repolarization in the failing heart.
Klein MG, Shou M, Stohlman J, Solhjoo S, Haigney M, Tidwell RR, Goldstein RE, Flagg TP, Haigney MC. Klein MG, et al. Heart Rhythm. 2017 Aug;14(8):1217-1223. doi: 10.1016/j.hrthm.2017.04.001. Epub 2017 Apr 8. Heart Rhythm. 2017. PMID: 28396172
BACKGROUND: The failing heart exhibits an increased arrhythmia susceptibility that is often attributed to action potential (AP) prolongation due to significant ion channel remodeling. The inwardly rectifying K(+) current (I(K1)) has been reported to be reduced, but its con …
BACKGROUND: The failing heart exhibits an increased arrhythmia susceptibility that is often attributed to action potential (AP) prolongation …