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Showing results for K. A. germinal
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Two complementary features of humoral immune memory confer protection against the same or variant antigens.
Van Beek M, Nussenzweig MC, Chakraborty AK. Van Beek M, et al. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2205598119. doi: 10.1073/pnas.2205598119. Epub 2022 Aug 25. Proc Natl Acad Sci U S A. 2022. PMID: 36006981 Free PMC article.
Upon infection or vaccination, B cells undergo a Darwinian evolutionary process in germinal centers (GCs), resulting in the production of antibodies and memory B cells. We developed a computational model to study how humoral memory is recalled upon reinfection or booster v …
Upon infection or vaccination, B cells undergo a Darwinian evolutionary process in germinal centers (GCs), resulting in the productio …
Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1.
Koenig JFE, Wade-Vallance AK, Jiménez-Saiz R, Bruton K, Gadkar S, Grydziuszko E, Walker TD, Gordon ME, Gillgrass AE, Taylor JJ, Waserman S, Jordana M. Koenig JFE, et al. Allergy. 2025 Aug;80(8):2141-2157. doi: 10.1111/all.16460. Epub 2025 Jan 13. Allergy. 2025. PMID: 39803817 Free PMC article.
At a cellular level, the capacity to undergo sequential switching through IgG1 provided no competitive advantage for subsequent IgE expression among germinal center B cells or plasma cells. Furthermore, the recall of allergic immunity at memory timepoints was preserved in …
At a cellular level, the capacity to undergo sequential switching through IgG1 provided no competitive advantage for subsequent IgE expressi …
Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity.
Yoshii K, Hosomi K, Shimoyama A, Wang Y, Yamaura H, Nagatake T, Suzuki H, Lan H, Kiyono H, Fukase K, Kunisawa J. Yoshii K, et al. Microorganisms. 2020 Jul 23;8(8):1102. doi: 10.3390/microorganisms8081102. Microorganisms. 2020. PMID: 32718009 Free PMC article.
Alcaligenes lipid A supported the generation of high levels of PspA-specific IgA and IgG responses through the augmentation of germinal center formation in the nasopharynx-associated lymphoid tissue and cervical lymph nodes (CLNs). ...
Alcaligenes lipid A supported the generation of high levels of PspA-specific IgA and IgG responses through the augmentation of germinal …
Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus.
Juul-Madsen K, Troldborg A, Wittenborn TR, Axelsen MG, Zhao H, Klausen LH, Luecke S, Paludan SR, Stengaard-Pedersen K, Dong M, Møller HJ, Thiel S, Jensen H, Schuck P, Sutherland DS, Degn SE, Vorup-Jensen T. Juul-Madsen K, et al. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2106647118. doi: 10.1073/pnas.2106647118. Proc Natl Acad Sci U S A. 2021. PMID: 34301873 Free PMC article.
Mechanistic insight from an animal model of lupus supported that DNA-stabilized superoligomers stimulate the formation of germinal center B cells and drive loss of immunological tolerance. The formation involves an inverse relationship between the concentration of MBL supe …
Mechanistic insight from an animal model of lupus supported that DNA-stabilized superoligomers stimulate the formation of germinal ce …
Human Germinal Center B Cells Differ from Naive and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response.
Huse K, Wogsland CE, Polikowsky HG, Diggins KE, Smeland EB, Myklebust JH, Irish JM. Huse K, et al. Cytometry A. 2019 Apr;95(4):442-449. doi: 10.1002/cyto.a.23737. Epub 2019 Mar 5. Cytometry A. 2019. PMID: 30838773 Free PMC article.
CD40 expression is required for germinal center (GC) formation and function, but the kinetics and magnitude of signaling following CD40 engagement remain poorly characterized in human B cells undergoing GC reactions. ...
CD40 expression is required for germinal center (GC) formation and function, but the kinetics and magnitude of signaling following CD …
Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity.
Walsh ER, Pisitkun P, Voynova E, Deane JA, Scott BL, Caspi RR, Bolland S. Walsh ER, et al. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16276-81. doi: 10.1073/pnas.1209372109. Epub 2012 Sep 17. Proc Natl Acad Sci U S A. 2012. PMID: 22988104 Free PMC article.
We determined that Tlr7 exerts B-cell-intrinsic effects in promoting spontaneous germinal center (GC) and plasmablast B-cell development, and that these B-cell subsets are dependent on T-cell-derived signals through CD40L and SLAM-associated protein (SAP), but not IL-17. A …
We determined that Tlr7 exerts B-cell-intrinsic effects in promoting spontaneous germinal center (GC) and plasmablast B-cell developm …
Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.
Morita K, Okamura T, Inoue M, Komai T, Teruya S, Iwasaki Y, Sumitomo S, Shoda H, Yamamoto K, Fujio K. Morita K, et al. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8131-E8140. doi: 10.1073/pnas.1611286114. Epub 2016 Nov 30. Proc Natl Acad Sci U S A. 2016. PMID: 27911796 Free PMC article.
In accordance with the observation that CD4(+)CD25(-)LAG3(+) cells from Egr2/3DKO mice completely lost the capacity to produce TGF-beta3, the excessive germinal center reaction in Egr2/3DKO mice was suppressed by the adoptive transfer of WT CD4(+)CD25(-)LAG3(+) cells or tr …
In accordance with the observation that CD4(+)CD25(-)LAG3(+) cells from Egr2/3DKO mice completely lost the capacity to produce TGF-beta3, th …
Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease.
Mantyh CR, Gates TS, Zimmerman RP, Welton ML, Passaro EP Jr, Vigna SR, Maggio JE, Kruger L, Mantyh PW. Mantyh CR, et al. Proc Natl Acad Sci U S A. 1988 May;85(9):3235-9. doi: 10.1073/pnas.85.9.3235. Proc Natl Acad Sci U S A. 1988. PMID: 2834738 Free PMC article.
Several lines of evidence indicate that tachykinin neuropeptides [substance P (SP), substance K (SK), and neuromedin K (NK)] play a role in regulating the inflammatory and immune responses. ...In addition, very high concentrations of SP receptor binding sites are ex …
Several lines of evidence indicate that tachykinin neuropeptides [substance P (SP), substance K (SK), and neuromedin K (NK)] p …
Mercury-induced alterations in rat kidneys and testes in vivo.
Massanyi P, Lukac N, Slivkova J, Kovacik J, Makarevich AV, Chrenek P, Toman R, Forgacs Z, Somosy Z, Stawarz R, Formicki G. Massanyi P, et al. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007 Jun;42(7):865-70. doi: 10.1080/10934520701370410. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007. PMID: 17558766
After the preparation of histological samples the results were compared with control group (K). In kidney decreased diameters of glomeruli and renal corpuscles, damaged tubules with affected quality of tubular cells and infiltration of interstitium were detected. ...In tes …
After the preparation of histological samples the results were compared with control group (K). In kidney decreased diameters of glom …
Influence of serotonin on the action of melatonin in MIH-induced meiotic resumption in the oocytes of carp Catla catla.
Chattoraj A, Seth M, Maitra SK. Chattoraj A, et al. Comp Biochem Physiol A Mol Integr Physiol. 2008 Jul;150(3):301-6. doi: 10.1016/j.cbpa.2008.03.014. Epub 2008 Mar 28. Comp Biochem Physiol A Mol Integr Physiol. 2008. PMID: 18455941
Oocytes from gravid female carp were isolated and incubated separately in Medium 199 containing either (a) only melatonin (MEL; 100 pg/mL), or (b) only serotonin (SER; 100 pg/mL), or (c) only MIH (1 microg/mL), or (d) MEL and MIH (e) or MEL (4 h before) and MIH, or (f) MEL and SE …
Oocytes from gravid female carp were isolated and incubated separately in Medium 199 containing either (a) only melatonin (MEL; 100 pg/mL), …
11 results