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Page 1
Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed.
Shon AS, Bajwa RP, Russo TA. Shon AS, et al. Virulence. 2013 Feb 15;4(2):107-18. doi: 10.4161/viru.22718. Epub 2013 Jan 9. Virulence. 2013. PMID: 23302790 Free PMC article. Review.
The traits that enhance its virulence when compared with "classical" K. pneumoniae are the ability to more efficiently acquire iron and perhaps an increase in capsule production, which confers the hypermucoviscous phenotype. ...
The traits that enhance its virulence when compared with "classical" K. pneumoniae are the ability to more efficiently acquire iron a …
Robotic Primary and Revisional Bariatric Surgery.
Iranmanesh P, Bajwa KS, Felinski MM, Shah SK, Wilson EB. Iranmanesh P, et al. Surg Clin North Am. 2020 Apr;100(2):417-430. doi: 10.1016/j.suc.2019.12.011. Epub 2020 Feb 1. Surg Clin North Am. 2020. PMID: 32169187 Review.
Peripartum Infections: A Position Statement of the Indian Society of Critical Care Medicine.
Samavedam S, Sodhi K, Anand P, Bajwa SJ, Karnad DR, Karanth S, Pandya ST, Patil LA, Sinha S, Trikha A. Samavedam S, et al. Indian J Crit Care Med. 2024 Aug;28(Suppl 2):S92-S103. doi: 10.5005/jp-journals-10071-24657. Epub 2024 Aug 10. Indian J Crit Care Med. 2024. PMID: 39234221 Free PMC article.
This position statement reviews the evidence and rationale for the management of severe peripartum infections with a special focus on tropical infections and is tailored for resource-limited settings. HOW TO CITE THIS ARTICLE: Samavedam S, Sodhi K, Anand P, Bajwa
This position statement reviews the evidence and rationale for the management of severe peripartum infections with a special focus on tropic …
Treatment of Richter's Transformation with Novel Therapies.
Bajwa A, Habib A, Kittai AS. Bajwa A, et al. Curr Hematol Malig Rep. 2024 Apr;19(2):45-55. doi: 10.1007/s11899-023-00721-8. Epub 2024 Jan 9. Curr Hematol Malig Rep. 2024. PMID: 38194201 Free PMC article. Review.
PURPOSE OF REVIEW: This review presents recently published clinical trial data and ongoing investigations regarding the treatment of Richter's transformation (RT). RECENT FINDINGS: Recently, numerous approaches have been investigated for the treatment of RT including: trad …
PURPOSE OF REVIEW: This review presents recently published clinical trial data and ongoing investigations regarding the treatment of Richter …
Bacterial catabolism of acetovanillone, a lignin-derived compound.
Dexter GN, Navas LE, Grigg JC, Bajwa H, Levy-Booth DJ, Liu J, Louie NA, Nasseri SA, Jang SK, Renneckar S, Eltis LD, Mohn WW. Dexter GN, et al. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2213450119. doi: 10.1073/pnas.2213450119. Epub 2022 Oct 18. Proc Natl Acad Sci U S A. 2022. PMID: 36256818 Free PMC article.
Furthermore, HpeCBA, a biotin-dependent enzyme, catalyzed the ATP-dependent carboxylation of 4-phospho-acetovanillone but not acetovanillone. The carboxylase's specificity for 4-phospho-acetophenone (k(cat)/K(M) = 34 2 mM(-1) s(-1)) was approximately a …
Furthermore, HpeCBA, a biotin-dependent enzyme, catalyzed the ATP-dependent carboxylation of 4-phospho-acetovanillone but not acetovanillone …
Preclinical rationale for entinostat in embryonal rhabdomyosarcoma.
Bharathy N, Berlow NE, Wang E, Abraham J, Settelmeyer TP, Hooper JE, Svalina MN, Bajwa Z, Goros MW, Hernandez BS, Wolff JE, Pal R, Davies AM, Ashok A, Bushby D, Mancini M, Noakes C, Goodwin NC, Ordentlich P, Keck J, Hawkins DS, Rudzinski ER, Mansoor A, Perkins TJ, Vakoc CR, Michalek JE, Keller C. Bharathy N, et al. Skelet Muscle. 2019 May 21;9(1):12. doi: 10.1186/s13395-019-0198-x. Skelet Muscle. 2019. PMID: 31113472 Free PMC article.
CONCLUSION: Our results suggest that the targeting class I HDACs may provide a therapeutic benefit for selected patients with eRMS. ENT's preclinical in vivo efficacy makes ENT a rational drug candidate in a phase II clinical trial for eRMS....
CONCLUSION: Our results suggest that the targeting class I HDACs may provide a therapeutic benefit for selected patients with eRMS. ENT's
Extended interval dosing with ocrelizumab in multiple sclerosis.
Novak F, Bajwa HM, Østergaard K, Berg JM, Madsen JS, Olsen DA, Urbonaviciute I, Illes Z, Stilund ML, Romme Christensen J, Bramow S, Sellebjerg F, Sejbaek T. Novak F, et al. Mult Scler. 2024 Jun;30(7):847-856. doi: 10.1177/13524585241245296. Epub 2024 Apr 22. Mult Scler. 2024. PMID: 38646949
Characterization of a phylogenetically distinct extradiol dioxygenase involved in the bacterial catabolism of lignin-derived aromatic compounds.
Navas LE, Zahn M, Bajwa H, Grigg JC, Wolf ME, Chan ACK, Murphy MEP, McGeehan JE, Eltis LD. Navas LE, et al. J Biol Chem. 2022 May;298(5):101871. doi: 10.1016/j.jbc.2022.101871. Epub 2022 Mar 26. J Biol Chem. 2022. PMID: 35346686 Free PMC article.
To better understand the role of AphC in RHA1 catabolism, we first showed that purified AphC had highest apparent specificity for 4-propylcatechol (k(cat)/K(M) 10(6) M(-1) s(-1)), and its apparent specificity for 4-alkylated substrates followed the trend for …
To better understand the role of AphC in RHA1 catabolism, we first showed that purified AphC had highest apparent specificity for 4-propylca …
27 results