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Non-vitamin K oral antagonist (NOAC) compared to vitamin K antagonist (VKA) in left ventricular thrombus.
Al-Kaf F, Al Basiri S, Al Ash'hab Y, Otain M, Al Askary H, Khushail AA, Robert AA, Al Fagih A. Al-Kaf F, et al. J Family Med Prim Care. 2024 Jun;13(6):2485-2490. doi: 10.4103/jfmpc.jfmpc_1905_23. Epub 2024 Jun 14. J Family Med Prim Care. 2024. PMID: 39027879 Free PMC article.
BACKGROUND: Thromboembolic events are serious left ventricular thrombus (LVT) complications. Despite the limitations of vitamin K antagonist (VKA) drugs, it continues to be the recommended oral anticoagulation for LVT. Recently, nonvitamin K oral antagonist (NOAC) h …
BACKGROUND: Thromboembolic events are serious left ventricular thrombus (LVT) complications. Despite the limitations of vitamin K ant …
The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism.
Haratizadeh S, Ranjbar M, Darvishzadeh-Mahani F, Basiri M, Nozari M. Haratizadeh S, et al. Dev Psychobiol. 2023 Jan;65(1):e22353. doi: 10.1002/dev.22353. Dev Psychobiol. 2023. PMID: 36567653
In this study, based on the excitatory/inhibitory imbalance theory of autism, the time window of GABA switch, the role of K-Cl co-transporter 2 (KCC2) in adjustment GABA switch, and brain permeability to erythropoietin (EPO), the effects of postnatal -EPO and- nano- erythr …
In this study, based on the excitatory/inhibitory imbalance theory of autism, the time window of GABA switch, the role of K-Cl co-tra …
Metabolite Profiling of the Antisense Oligonucleotide Eluforsen Using Liquid Chromatography-Mass Spectrometry.
Kim J, Basiri B, Hassan C, Punt C, van der Hage E, den Besten C, Bartlett MG. Kim J, et al. Mol Ther Nucleic Acids. 2019 Sep 6;17:714-725. doi: 10.1016/j.omtn.2019.07.006. Epub 2019 Jul 22. Mol Ther Nucleic Acids. 2019. PMID: 31422288 Free PMC article.
Solid-phase extraction was used following proteinase K digestion for sample preparation. Chain-shortened metabolites of eluforsen by 3' exonuclease were observed in mouse liver in an in vitro incubation system and by either 3' exonuclease or 5' exonuclease in liver and lun …
Solid-phase extraction was used following proteinase K digestion for sample preparation. Chain-shortened metabolites of eluforsen by …
Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.
Kia Y, Osman H, Kumar RS, Murugaiyah V, Basiri A, Perumal S, Wahab HA, Bing CS. Kia Y, et al. Bioorg Med Chem. 2013 Apr 1;21(7):1696-707. doi: 10.1016/j.bmc.2013.01.066. Epub 2013 Feb 8. Bioorg Med Chem. 2013. PMID: 23454132
The in vitro evaluation of cholinesterase enzymes inhibitory activity of these cycloadducts disclosed that monospiripyrrolizines (8a-k), are more active with IC50 ranging from 3.36 to 20.07 muM than either the dipolarophiles (5a-k) or bisspiropyrrolizines (9a-k …
The in vitro evaluation of cholinesterase enzymes inhibitory activity of these cycloadducts disclosed that monospiripyrrolizines (8a-k …