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Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1.
Jarjour AA, Bull SJ, Almasieh M, Rajasekharan S, Baker KA, Mui J, Antel JP, Di Polo A, Kennedy TE. Jarjour AA, et al. J Neurosci. 2008 Oct 22;28(43):11003-14. doi: 10.1523/JNEUROSCI.3285-08.2008. J Neurosci. 2008. PMID: 18945908 Free PMC article.
Furthermore, the domain organization of myelin is compromised in the absence of netrin-1 signaling: K+ channels inappropriately invade the paranodal region, and the normally restricted paranodal distribution of Caspr expands longitudinally along the axon. ...
Furthermore, the domain organization of myelin is compromised in the absence of netrin-1 signaling: K+ channels inappropriately invad …