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Page 1
Aberrant Histone Methylation Profile in Patients with Sporadic Primary Hyperparathyroidism.
Kumari P, Bhadada SK, Arya AK, Kaur J, Sachdeva N, Saikia UN, Dahiya D, Kumar A, Kharbanda C, Rao SD. Kumari P, et al. J Clin Endocrinol Metab. 2026 May 19;111(6):1680-1691. doi: 10.1210/clinem/dgaf668. J Clin Endocrinol Metab. 2026. PMID: 41396875
RESULTS: We observed dynamic alterations in histone H3 modifications of lysine (K) residues across parathyroid tumor phenotypes in blood and tissue samples. A reduction in H3K4 and H3K36 trimethylation (<60%) and an increase in H3K27 trimethylation and H3K9 monomethylat …
RESULTS: We observed dynamic alterations in histone H3 modifications of lysine (K) residues across parathyroid tumor phenotypes in bl …
Classification of drug molecules for oxidative stress signalling pathway.
Verma N, Singh H, Khanna D, Rana PS, Bhadada SK. Verma N, et al. IET Syst Biol. 2019 Oct;13(5):243-250. doi: 10.1049/iet-syb.2018.5078. IET Syst Biol. 2019. PMID: 31538958 Free PMC article.
The validation of the proposed scheme is done using the K-fold cross-validation method and an accuracy of 90% is achieved for prediction of activity score for ARE molecules which determine their power to refine oxidative stress....
The validation of the proposed scheme is done using the K-fold cross-validation method and an accuracy of 90% is achieved for predict …
Pre-exposure of voglibose exerts cerebroprotective effects through attenuating activation of the polyol pathway and inflammation.
Chavda V, Shah P, Patel SS, Bhadada S. Chavda V, et al. Eur J Neurosci. 2021 Apr;53(8):2541-2552. doi: 10.1111/ejn.15151. Epub 2021 Mar 8. Eur J Neurosci. 2021. PMID: 33608957

In the end, brain samples were excised for determination of brain infarct volume, brain hemisphere weight difference, Na+-K+ ATPase activity oxidative stress-related parameters, aldose reductase activity, and gene expression studies. ...Voglibose significantly (p < .05)

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In the end, brain samples were excised for determination of brain infarct volume, brain hemisphere weight difference, Na+-K+ ATPase a …
Magnesium valproate ameliorates type 1 diabetes and cardiomyopathy in diabetic rats through estrogen receptors.
Rabadiya S, Bhadada S, Dudhrejiya A, Vaishnav D, Patel B. Rabadiya S, et al. Biomed Pharmacother. 2018 Jan;97:919-927. doi: 10.1016/j.biopha.2017.10.137. Epub 2017 Nov 7. Biomed Pharmacother. 2018. PMID: 29136770
MgV also significantly reduced left ventricular hypertrophy index and cardiac hypertrophy index, LV wall thickness, LV collagen, cardiomyocyte diameter and prevented the oxidative stress with significant increase in Na(+)-K(+)-ATPase activity in LV. Moreover, MgV reversed …
MgV also significantly reduced left ventricular hypertrophy index and cardiac hypertrophy index, LV wall thickness, LV collagen, cardiomyocy …
Development of the Asia Pacific Consortium on Osteoporosis (APCO) Framework: clinical standards of care for the screening, diagnosis, and management of osteoporosis in the Asia-Pacific region.
Chandran M, Mitchell PJ, Amphansap T, Bhadada SK, Chadha M, Chan DC, Chung YS, Ebeling P, Gilchrist N, Habib Khan A, Halbout P, Hew FL, Lan HT, Lau TC, Lee JK, Lekamwasam S, Lyubomirsky G, Mercado-Asis LB, Mithal A, Nguyen TV, Pandey D, Reid IR, Suzuki A, Chit TT, Tiu KL, Valleenukul T, Yung CK, Zhao YL; Asia Pacific Consortium on Osteoporosis (APCO). Chandran M, et al. Osteoporos Int. 2021 Jul;32(7):1249-1275. doi: 10.1007/s00198-020-05742-0. Epub 2021 Jan 27. Osteoporos Int. 2021. PMID: 33502559 Free PMC article.
Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies.
Shah P, Chavda V, Patel S, Bhadada S, Ashraf GM. Shah P, et al. Curr Gene Ther. 2020;20(3):223-235. doi: 10.2174/1566523220999200726225457. Curr Gene Ther. 2020. PMID: 33054705
Brains were excised for determination of brain infarct volume, brain hemisphere weight difference, Na+-K+ ATPase activity, ROS parameters, NO levels, and aldose reductase activity. RESULTS: In-silico docking studies showed good docking binding score for stroke associated p …
Brains were excised for determination of brain infarct volume, brain hemisphere weight difference, Na+-K+ ATPase activity, ROS parame …