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Cord blood DNA methylation signatures associated with preeclampsia are enriched for cardiovascular pathways: insights from the VDAART trial.
Knihtilä HM, Kachroo P, Shadid I, Raissadati A, Peng C, McElrath TF, Litonjua AA, Demeo DL, Loscalzo J, Weiss ST, Mirzakhani H. Knihtilä HM, et al. EBioMedicine. 2023 Dec;98:104890. doi: 10.1016/j.ebiom.2023.104890. Epub 2023 Nov 22. EBioMedicine. 2023. PMID: 37995466 Free PMC article.
We performed an epigenome-wide association study of preeclampsia and cord blood DNA methylation (Illumina 450 K chip). We then examined gene expression of the same subjects for validation and replicated the gene signatures in independent DNA methylation datasets. ...
We performed an epigenome-wide association study of preeclampsia and cord blood DNA methylation (Illumina 450 K chip). We then examin …
Late first trimester circulating microparticle proteins predict the risk of preeclampsia < 35 weeks and suggest phenotypic differences among affected cases.
McElrath TF, Cantonwine DE, Gray KJ, Mirzakhani H, Doss RC, Khaja N, Khalid M, Page G, Brohman B, Zhang Z, Sarracino D, Rosenblatt KP. McElrath TF, et al. Sci Rep. 2020 Oct 21;10(1):17353. doi: 10.1038/s41598-020-74078-w. Sci Rep. 2020. PMID: 33087742 Free PMC article.
Logistic models then determined feature selection with best performing models determined by cross-validation. K-means clustering examined cases for phenotypic subtypes and biological pathway enrichment was examined. ...
Logistic models then determined feature selection with best performing models determined by cross-validation. K-means clustering exam …