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Page 1
Development of High-Affinity CHD1 Chromodomain Inhibitors.
Greschik H, Friedrich F, Seifert L, Mousavizadeh F, Fiorentino F, Walz J, Zhang L, Li J, Fabbrizi E, Tomassi S, Panahi F, Papenkordt N, Wurnig SL, Osterroth J, Strasser AM, Ruprecht J, Moumbock AFA, Hügle M, Sum M, Peng L, Wang S, Baniahmad AA, Pulido-Cortés L, Timmers HTM, Flaig R, Metzger E, Breit B, Einsle O, Günther S, Rotili D, Mai A, Schüle R, Jung M. Greschik H, et al. J Med Chem. 2026 May 28;69(10):12020-12047. doi: 10.1021/acs.jmedchem.5c03690. Epub 2026 May 5. J Med Chem. 2026. PMID: 42085696 Free PMC article.
We developed the first submicromolar inhibitors (2n and 2s) that target the H3K4me3 binding site of the CHD1 tCD with K(d) values of 0.15 muM and 0.14 muM, respectively. Co-crystal structures of these quinoline-based compounds revealed aromatic cage interactions and extend …
We developed the first submicromolar inhibitors (2n and 2s) that target the H3K4me3 binding site of the CHD1 tCD with K(d) values of …
Alteration by ouabain of rat submandibular glands function.
Dehpour AR, Ghafourifar P, Juibari AM, Mousavizadeh K. Dehpour AR, et al. Gen Pharmacol. 1995 Sep;26(5):1009-13. doi: 10.1016/0306-3623(94)00285-u. Gen Pharmacol. 1995. PMID: 7557242
Potassium and calcium and their product (K+ x Ca2+) were found to be elevated in all groups. 3. Changes in salivary flow were not the major cause of the alterations in electrolytes. 4. ...
Potassium and calcium and their product (K+ x Ca2+) were found to be elevated in all groups. 3. Changes in salivary flow were not the …
Cyclosporin A-induced functional and morphological changes in pilocarpine treated rat submandibular glands.
Dehpour AR, Nouhnejad P, Mousavizadeh K, Ghafourifar P, Djamali M, Borhanimoghadam B. Dehpour AR, et al. Toxicology. 1996 Apr 15;108(1-2):65-71. doi: 10.1016/s0300-483x(95)03278-n. Toxicology. 1996. PMID: 8644119
Sialochemistry studies revealed a reduction of pilocarpine-stimulated flow rates to 54% compared to the controls. Salivary Mg(2+) and K+ were elevated and a marked decrease in total protein concentration was observed. ...
Sialochemistry studies revealed a reduction of pilocarpine-stimulated flow rates to 54% compared to the controls. Salivary Mg(2+) and K …