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Page 1
Synthesis and crystallographic analysis of two rhizopuspepsin inhibitor complexes.
Parris KD, Hoover DJ, Damon DB, Davies DR. Parris KD, et al. Biochemistry. 1992 Sep 8;31(35):8125-41. doi: 10.1021/bi00150a004. Biochemistry. 1992. PMID: 1525154
The second inhibitor, a hydrated difluorostatone, was examined in a search for transition-state analogs that could cast further light on the mechanism of action [Suguna, K., Padlan, E. A., Smith, C. W., Carlson, W. D., & Davies, D. R. (1987) Proc. Natl. ...These …
The second inhibitor, a hydrated difluorostatone, was examined in a search for transition-state analogs that could cast further light on the …
Structural and functional characterization of mercuric reductase from Lysinibacillus sphaericus strain G1.
Bafana A, Khan F, Suguna K. Bafana A, et al. Biometals. 2017 Oct;30(5):809-819. doi: 10.1007/s10534-017-0050-x. Epub 2017 Sep 11. Biometals. 2017. PMID: 28894951
The enzyme was homodimeric with subunit molecular weight of about 60 kDa. The K(m) and V(max) were found to be 32 M of HgCl(2) and 18 units/mg respectively. The enzyme activity was enhanced by beta-mercaptoethanol and NaCl up to concentrations of 500 M and 100 mM respectiv …
The enzyme was homodimeric with subunit molecular weight of about 60 kDa. The K(m) and V(max) were found to be 32 M of HgCl(2) and 18 …
Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+.
Kapoor M, Mukhi PL, Surolia N, Suguna K, Surolia A. Kapoor M, et al. Biochem J. 2004 Aug 1;381(Pt 3):725-33. doi: 10.1042/BJ20040228. Biochem J. 2004. PMID: 15125687 Free PMC article.
The increase in the binding constant was due to a 17 times increase in the association rate constant (k(1)) from 741 M(-1) x s(-1) to 1.3x10(4) M(-1) x s(-1) and a 16 times decrease in the dissociation rate constant (k(-1)) from 6.84x10(-3) s(-1) to 4.2x10(-4) s(-1) …
The increase in the binding constant was due to a 17 times increase in the association rate constant (k(1)) from 741 M(-1) x s(-1) to …
Functional inactivation of the human guanylyl cyclase C receptor: modeling and mutation of the protein kinase-like domain.
Bhandari R, Srinivasan N, Mahaboobi M, Ghanekar Y, Suguna K, Visweswariah SS. Bhandari R, et al. Biochemistry. 2001 Aug 7;40(31):9196-206. doi: 10.1021/bi002595g. Biochemistry. 2001. PMID: 11478887
We therefore suggest that the KHD in receptor guanylyl cyclases provides a critical structural link between the extracellular domain and the catalytic domain in regulation of activity in this family of receptors, and the presence of K(516) is critical for the possible prop …
We therefore suggest that the KHD in receptor guanylyl cyclases provides a critical structural link between the extracellular domain and the …
Crystallization and preliminary X-ray crystallographic analysis of a galactose-specific lectin from Dolichos lablab.
Latha VL, Kulkarni KA, Rao RN, Kumar NS, Suguna K. Latha VL, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Feb 1;62(Pt 2):163-5. doi: 10.1107/S1744309106001448. Epub 2006 Jan 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16511291 Free PMC article.
X-ray diffraction data to a resolution of 3.0 A have been collected under cryoconditions (100 K) using a MAR imaging-plate detector system mounted on a rotating-anode X-ray generator. ...
X-ray diffraction data to a resolution of 3.0 A have been collected under cryoconditions (100 K) using a MAR imaging-plate detector s …
Conformational stability and thermodynamic characterization of homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase.
Karmodiya K, Sajad S, Sinha S, Maity K, Suguna K, Surolia N. Karmodiya K, et al. IUBMB Life. 2007 Jul;59(7):441-9. doi: 10.1080/15216540701472113. IUBMB Life. 2007. PMID: 17654120 Free article.
In addition, the conformational stability (Delta G(s)) as well as the Delta C(p) for the protein unfolding is quite high, 22.68 kcal/mole and 5.83 kcal/(mole K), respectively, which may be a reflection of the relatively large size of the tetrameric molecule (Mr 120, 000) a …
In addition, the conformational stability (Delta G(s)) as well as the Delta C(p) for the protein unfolding is quite high, 22.68 kcal/mole an …
Crystallization and preliminary crystallographic analysis of beta-hydroxyacyl ACP dehydratase (FabZ) from Plasmodium falciparum.
Lakshmi Swarna Mukhi P, Kumar Sharma S, Kapoor M, Surolia N, Surolia A, Suguna K. Lakshmi Swarna Mukhi P, et al. Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):120-1. doi: 10.1107/s0907444903022327. Epub 2003 Dec 18. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 14684903
A complete data set to a resolution of 2.5 A has been collected under cryoconditions (100 K) using a MAR imaging-plate detector system mounted on a rotating-anode X-ray generator....
A complete data set to a resolution of 2.5 A has been collected under cryoconditions (100 K) using a MAR imaging-plate detector syste …