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An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes - application to establishing CYP2C8 inhibitor selectivity.

Kahma H, Aurinsalo L, Neuvonen M, Katajamäki J, Paludetto MN, Viinamäki J, Launiainen T, Filppula AM, Tornio A, Niemi M, Backman JT. Kahma H, et al. Eur J Pharm Sci. 2021 Jul 1;162:105810. doi: 10.1016/j.ejps.2021.105810. Epub 2021 Mar 19. Eur J Pharm Sci. 2021. PMID: 33753217 Free article.

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8.

Kahma H, Filppula AM, Launiainen T, Viinamäki J, Neuvonen M, Evangelista EA, Totah RA, Backman JT. Kahma H, et al. Drug Metab Dispos. 2019 Apr;47(4):436-443. doi: 10.1124/dmd.118.085498. Epub 2019 Feb 1. Drug Metab Dispos. 2019. PMID: 30709838

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions.

Kahma H, Filppula AM, Neuvonen M, Tarkiainen EK, Tornio A, Holmberg MT, Itkonen MK, Finel M, Neuvonen PJ, Niemi M, Backman JT. Kahma H, et al. Drug Metab Dispos. 2018 Feb;46(2):141-150. doi: 10.1124/dmd.117.078162. Epub 2017 Nov 14. Drug Metab Dispos. 2018. PMID: 29138287

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