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26 results

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Page 1
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.
Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y. Anastas JN, et al. Among authors: kalin jh. Cancer Cell. 2019 Nov 11;36(5):528-544.e10. doi: 10.1016/j.ccell.2019.09.005. Epub 2019 Oct 17. Cancer Cell. 2019. PMID: 31631026 Free article.
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.
Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA. Kalin JH, et al. Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4. Nat Commun. 2018. PMID: 29302039 Free PMC article.
Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor.
Diaz E, Adhikary S, Tepper AWJW, Riley D, Ortiz-Meoz R, Krosky D, Buyck C, Lamenca CM, Llaveria J, Fang L, Kalin JH, Klaren VNA, Fahmy S, Shaffer PL, Kirkpatrick R, Carbajo RJ, Thomsen M, Impagliazzo A. Diaz E, et al. Among authors: kalin jh. Commun Biol. 2022 Aug 5;5(1):787. doi: 10.1038/s42003-022-03735-9. Commun Biol. 2022. PMID: 35931745 Free PMC article.
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes.
Padalino G, Celatka CA, Rienhoff HY Jr, Kalin JH, Cole PA, Lassalle D, Forde-Thomas J, Chalmers IW, Brancale A, Grunau C, Hoffmann KF. Padalino G, et al. Among authors: kalin jh. Wellcome Open Res. 2023 Mar 30;8:146. doi: 10.12688/wellcomeopenres.18826.1. eCollection 2023. Wellcome Open Res. 2023. PMID: 37520936 Free PMC article.
DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.
Carney SM, Grosse S, Yin Y, Tran MT, Kalin JH, Jacoby E, Fung A, Simmons N, Xie X, Bhaumik A, Carbajo RJ, Piassek M, Miller R, Hu L, Lemmens C, Lutter FH, Pieters S, Rombouts G, Vetrano I, Oehlrich D, Tomaso S, Lozada K, Garcia MO, Anson B, De Bruyn S, Smith-Monroy C, Neefs JM, Conceição-Neto N, Kesteleyn B, Fino R, Stoops B, van Vlijmen H, Patrick AN, Yu X, Wong V, Krosky DJ, Abeywickrema P, Ortiz-Meoz RF, Mason SW, Jin Z, Sharma S, Jonckers THM. Carney SM, et al. Among authors: kalin jh. J Med Chem. 2025 Mar 5. doi: 10.1021/acs.jmedchem.4c02906. Online ahead of print. J Med Chem. 2025. PMID: 40042938
26 results