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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 1
1948 1
1951 1
1957 1
1959 1
1961 2
1964 1
1966 2
1972 1
1979 1
1986 2
1987 2
1988 2
1989 2
1991 1
1993 1
1994 1
1997 3
1998 1
1999 3
2000 3
2001 4
2002 3
2003 4
2004 8
2005 5
2006 10
2007 13
2008 7
2009 3
2010 7
2011 8
2012 3
2013 5
2014 5
2015 6
2016 3
2017 5
2018 2
2019 1
2020 2
2021 6
2022 4
2023 2
2024 2

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138 results

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Page 1
The global preclinical antibacterial pipeline.
Theuretzbacher U, Outterson K, Engel A, Karlén A. Theuretzbacher U, et al. Among authors: karlen a. Nat Rev Microbiol. 2020 May;18(5):275-285. doi: 10.1038/s41579-019-0288-0. Epub 2019 Nov 19. Nat Rev Microbiol. 2020. PMID: 31745331 Free PMC article. Review.
Towards the sustainable discovery and development of new antibiotics.
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Miethke M, et al. Among authors: karlen a. Nat Rev Chem. 2021 Oct;5(10):726-749. doi: 10.1038/s41570-021-00313-1. Epub 2021 Aug 19. Nat Rev Chem. 2021. PMID: 37118182 Review.
Towards the sustainable discovery and development of new antibiotics.
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Miethke M, et al. Among authors: karlen a. Nat Rev Chem. 2021;5(10):726-749. doi: 10.1038/s41570-021-00313-1. Epub 2021 Aug 19. Nat Rev Chem. 2021. PMID: 34426795 Free PMC article. Review.
Discovery and preclinical development of new antibiotics.
Hughes D, Karlén A. Hughes D, et al. Among authors: karlen a. Ups J Med Sci. 2014 May;119(2):162-9. doi: 10.3109/03009734.2014.896437. Epub 2014 Mar 19. Ups J Med Sci. 2014. PMID: 24646082 Free PMC article. Review.
Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Huseby DL, Cao S, Zamaratski E, Sooriyaarachchi S, Ahmad S, Bergfors T, Krasnova L, Pelss J, Ikaunieks M, Loza E, Katkevics M, Bobileva O, Cirule H, Gukalova B, Grinberga S, Backlund M, Simoff I, Leber AT, Berruga-Fernández T, Antonov D, Konda VR, Lindström S, Olanders G, Brandt P, Baranczewski P, Vingsbo Lundberg C, Liepinsh E, Suna E, Jones TA, Mowbray SL, Hughes D, Karlén A. Huseby DL, et al. Among authors: karlen a. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2317274121. doi: 10.1073/pnas.2317274121. Epub 2024 Apr 5. Proc Natl Acad Sci U S A. 2024. PMID: 38579010 Free PMC article.
Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule.
Grinkevich VV, Vema A, Fawkner K, Issaeva N, Andreotti V, Dickinson ER, Hedström E, Spinnler C, Inga A, Larsson LG, Karlén A, Wilhelm M, Barran PE, Okorokov AL, Selivanova G, Zawacka-Pankau JE. Grinkevich VV, et al. Among authors: karlen a. Front Mol Biosci. 2022 Jun 1;9:823195. doi: 10.3389/fmolb.2022.823195. eCollection 2022. Front Mol Biosci. 2022. PMID: 35720128 Free PMC article.
The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance.
Kostyanev T, Bonten MJ, O'Brien S, Steel H, Ross S, François B, Tacconelli E, Winterhalter M, Stavenger RA, Karlén A, Harbarth S, Hackett J, Jafri HS, Vuong C, MacGowan A, Witschi A, Angyalosi G, Elborn JS, deWinter R, Goossens H. Kostyanev T, et al. Among authors: karlen a. J Antimicrob Chemother. 2016 Feb;71(2):290-5. doi: 10.1093/jac/dkv339. Epub 2015 Nov 15. J Antimicrob Chemother. 2016. PMID: 26568581 Review.
138 results