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Kidney and epigenetic mechanisms of salt-sensitive hypertension.

Kawarazaki W, Fujita T. Kawarazaki W, et al. Nat Rev Nephrol. 2021 May;17(5):350-363. doi: 10.1038/s41581-021-00399-2. Epub 2021 Feb 24. Nat Rev Nephrol. 2021. PMID: 33627838 Review.

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Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency.

Kawarazaki W, Mizuno R, Nishimoto M, Ayuzawa N, Hirohama D, Ueda K, Kawakami-Mori F, Oba S, Marumo T, Fujita T. Kawarazaki W, et al. J Clin Invest. 2020 Aug 3;130(8):4152-4166. doi: 10.1172/JCI134431. J Clin Invest. 2020. PMID: 32597829 Free PMC article.

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Role of Rho in Salt-Sensitive Hypertension.

Kawarazaki W, Fujita T. Kawarazaki W, et al. Int J Mol Sci. 2021 Mar 15;22(6):2958. doi: 10.3390/ijms22062958. Int J Mol Sci. 2021. PMID: 33803946 Free PMC article. Review.

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The Role of Aldosterone in Obesity-Related Hypertension.

Kawarazaki W, Fujita T. Kawarazaki W, et al. Am J Hypertens. 2016 Apr;29(4):415-23. doi: 10.1093/ajh/hpw003. Epub 2016 Feb 28. Am J Hypertens. 2016. PMID: 26927805 Free PMC article. Review.

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Aberrant Rac1-mineralocorticoid receptor pathways in salt-sensitive hypertension.

Kawarazaki W, Fujita T. Kawarazaki W, et al. Clin Exp Pharmacol Physiol. 2013 Dec;40(12):929-36. doi: 10.1111/1440-1681.12177. Clin Exp Pharmacol Physiol. 2013. PMID: 24111570 Review.

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Activation of Rac1-Mineralocorticoid Receptor Pathway Contributes to Renal Injury in Salt-Loaded db/db Mice.

Hirohama D, Nishimoto M, Ayuzawa N, Kawarazaki W, Fujii W, Oba S, Shibata S, Marumo T, Fujita T. Hirohama D, et al. Among authors: kawarazaki w. Hypertension. 2021 Jul;78(1):82-93. doi: 10.1161/HYPERTENSIONAHA.121.17263. Epub 2021 Jun 1. Hypertension. 2021. PMID: 34058848

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Two Mineralocorticoid Receptor-Mediated Mechanisms of Pendrin Activation in Distal Nephrons.

Ayuzawa N, Nishimoto M, Ueda K, Hirohama D, Kawarazaki W, Shimosawa T, Marumo T, Fujita T. Ayuzawa N, et al. Among authors: kawarazaki w. J Am Soc Nephrol. 2020 Apr;31(4):748-764. doi: 10.1681/ASN.2019080804. Epub 2020 Feb 7. J Am Soc Nephrol. 2020. PMID: 32034107 Free PMC article.

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Aldosterone Is Essential for Angiotensin II-Induced Upregulation of Pendrin.

Hirohama D, Ayuzawa N, Ueda K, Nishimoto M, Kawarazaki W, Watanabe A, Shimosawa T, Marumo T, Shibata S, Fujita T. Hirohama D, et al. Among authors: kawarazaki w. J Am Soc Nephrol. 2018 Jan;29(1):57-68. doi: 10.1681/ASN.2017030243. Epub 2017 Oct 11. J Am Soc Nephrol. 2018. PMID: 29021385 Free PMC article.

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Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells.

Oba S, Ayuzawa N, Nishimoto M, Kawarazaki W, Ueda K, Hirohama D, Kawakami-Mori F, Shimosawa T, Marumo T, Fujita T. Oba S, et al. Among authors: kawarazaki w. Sci Rep. 2018 Nov 5;8(1):16338. doi: 10.1038/s41598-018-34612-3. Sci Rep. 2018. PMID: 30397232 Free PMC article.

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Methylation pattern of urinary DNA as a marker of kidney function decline in diabetes.

Marumo T, Hoshino J, Kawarazaki W, Nishimoto M, Ayuzawa N, Hirohama D, Yamanouchi M, Ubara Y, Okaneya T, Fujii T, Yuki K, Atsumi Y, Sato A, Arai E, Kanai Y, Shimosawa T, Fujita T. Marumo T, et al. Among authors: kawarazaki w. BMJ Open Diabetes Res Care. 2020 Sep;8(1):e001501. doi: 10.1136/bmjdrc-2020-001501. BMJ Open Diabetes Res Care. 2020. PMID: 32883689 Free PMC article.

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