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Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics.
Kimura I, Yamasoba D, Nasser H, Ito H, Zahradnik J, Wu J, Fujita S, Uriu K, Sasaki J, Tamura T, Suzuki R, Deguchi S, Plianchaisuk A, Yoshimatsu K, Kazuma Y, Mitoma S, Schreiber G, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Takaori-Kondo A; Genotype to Phenotype Japan (G2P-Japan) Consortium; Ito J, Shirakawa K, Takayama K, Irie T, Hashiguchi T, Nakagawa S, Fukuhara T, Saito A, Ikeda T, Sato K. Kimura I, et al. Among authors: kazuma y. J Virol. 2023 Oct 31;97(10):e0101123. doi: 10.1128/jvi.01011-23. Epub 2023 Oct 5. J Virol. 2023. PMID: 37796123 Free PMC article.
The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance.
Kimura I, Kosugi Y, Wu J, Zahradnik J, Yamasoba D, Butlertanaka EP, Tanaka YL, Uriu K, Liu Y, Morizako N, Shirakawa K, Kazuma Y, Nomura R, Horisawa Y, Tokunaga K, Ueno T, Takaori-Kondo A, Schreiber G, Arase H; Genotype to Phenotype Japan (G2P-Japan) Consortium; Motozono C, Saito A, Nakagawa S, Sato K. Kimura I, et al. Among authors: kazuma y. Cell Rep. 2022 Jan 11;38(2):110218. doi: 10.1016/j.celrep.2021.110218. Epub 2021 Dec 18. Cell Rep. 2022. PMID: 34968415 Free PMC article.
Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation.
Saito A, Irie T, Suzuki R, Maemura T, Nasser H, Uriu K, Kosugi Y, Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertanaka EP, Tanaka YL, Shimizu R, Shimizu K, Yoshimatsu K, Kawabata R, Sakaguchi T, Tokunaga K, Yoshida I, Asakura H, Nagashima M, Kazuma Y, Nomura R, Horisawa Y, Yoshimura K, Takaori-Kondo A, Imai M; Genotype to Phenotype Japan (G2P-Japan) Consortium; Tanaka S, Nakagawa S, Ikeda T, Fukuhara T, Kawaoka Y, Sato K. Saito A, et al. Among authors: kazuma y. Nature. 2022 Feb;602(7896):300-306. doi: 10.1038/s41586-021-04266-9. Epub 2021 Nov 25. Nature. 2022. PMID: 34823256 Free PMC article.
Summary of the current status of clinically diagnosed cases of Schnitzler syndrome in Japan.
Takimoto-Ito R, Kambe N, Kogame T, Nomura T, Izawa K, Jo T, Kazuma Y, Yoshifuji H, Tabuchi Y, Abe H, Yamamoto M, Nakajima K, Tomita O, Yagi Y, Katagiri K, Matsuzaka Y, Takeuchi Y, Hatanaka M, Kanekura T, Takeuchi S, Kadono T, Fujita Y, Migita K, Fujino T, Akagi T, Mukai T, Nagano T, Kawano M, Kimura H, Okubo Y, Morita A, Hide M, Satoh T, Asahina A, Kanazawa N, Kabashima K. Takimoto-Ito R, et al. Among authors: kazuma y. Allergol Int. 2023 Apr;72(2):297-305. doi: 10.1016/j.alit.2022.11.004. Epub 2022 Dec 2. Allergol Int. 2023. PMID: 36470790 Free article.
A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron.
Maeda R, Fujita J, Konishi Y, Kazuma Y, Yamazaki H, Anzai I, Watanabe T, Yamaguchi K, Kasai K, Nagata K, Yamaoka Y, Miyakawa K, Ryo A, Shirakawa K, Sato K, Makino F, Matsuura Y, Inoue T, Imura A, Namba K, Takaori-Kondo A. Maeda R, et al. Among authors: kazuma y. Commun Biol. 2022 Jul 6;5(1):669. doi: 10.1038/s42003-022-03630-3. Commun Biol. 2022. PMID: 35794202 Free PMC article.
APOBEC3B is preferentially expressed at the G2/M phase of cell cycle.
Hirabayashi S, Shirakawa K, Horisawa Y, Matsumoto T, Matsui H, Yamazaki H, Sarca AD, Kazuma Y, Nomura R, Konishi Y, Takeuchi S, Stanford E, Kawaji H, Murakawa Y, Takaori-Kondo A. Hirabayashi S, et al. Among authors: kazuma y. Biochem Biophys Res Commun. 2021 Mar 26;546:178-184. doi: 10.1016/j.bbrc.2021.02.008. Epub 2021 Feb 13. Biochem Biophys Res Commun. 2021. PMID: 33592502 Free article.
Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation.
Matsumoto T, Shirakawa K, Yokoyama M, Fukuda H, Sarca AD, Koyabu S, Yamazaki H, Kazuma Y, Matsui H, Maruyama W, Nagata K, Tanabe F, Kobayashi M, Shindo K, Morishita R, Sato H, Takaori-Kondo A. Matsumoto T, et al. Among authors: kazuma y. Sci Rep. 2019 Jun 5;9(1):8307. doi: 10.1038/s41598-019-44407-9. Sci Rep. 2019. PMID: 31165764 Free PMC article.
Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice.
Nagata K, Utsumi D, Asaka MN, Maeda R, Shirakawa K, Kazuma Y, Nomura R, Horisawa Y, Yanagida Y, Kawai Y, Sato K, Yamaoka Y, Miyakawa K, Ryo A, Yasutomi Y, Imura A, Takaori-Kondo A. Nagata K, et al. Among authors: kazuma y. Commun Med (Lond). 2022 Nov 26;2(1):152. doi: 10.1038/s43856-022-00213-5. Commun Med (Lond). 2022. PMID: 36435945 Free PMC article.
21 results