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Page 1
Altered expression of KCNG3 and KCNG4 in Hirschsprung's disease.
O'Donnell AM, Nakamura H, Tomuschat C, Marayati NF, Puri P. O'Donnell AM, et al. Pediatr Surg Int. 2019 Feb;35(2):193-197. doi: 10.1007/s00383-018-4394-2. Epub 2018 Nov 1. Pediatr Surg Int. 2019. PMID: 30386900
We designed this study to investigate KCNG3 and KCNG4 expression in the normal human colon and in Hirschsprung's disease (HSCR). ...KCNG3 and KCNG4 downregulation within ganglionic specimens highlights the physiologically abnormal nature of this segment in HSCR pati …
We designed this study to investigate KCNG3 and KCNG4 expression in the normal human colon and in Hirschsprung's disease (HSCR). ... …
A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers.
Stewart RG, Marquis MJ, Jo S, Aberra A, Cook V, Whiddon Z, Ferns M, Sack JT. Stewart RG, et al. bioRxiv [Preprint]. 2024 May 14:2024.01.31.578214. doi: 10.1101/2024.01.31.578214. bioRxiv. 2024. PMID: 38352561 Free PMC article. Preprint.
Mammals have 10 KvS subunits: Kv5.1 ( KCNF1 ), Kv6.1 ( KCNG1 ), Kv6.2 ( KCNG2 ), Kv6.3 ( KCNG3 ), Kv6.4 ( KCNG4 ), Kv8.1 ( KCNV1 ), Kv8.2 ( KCNV2 ), Kv9.1 ( KCNS1 ), Kv9.2 ( KCNS2 ), and Kv9.3 ( KCNS3 ). ...
Mammals have 10 KvS subunits: Kv5.1 ( KCNF1 ), Kv6.1 ( KCNG1 ), Kv6.2 ( KCNG2 ), Kv6.3 ( KCNG3 ), Kv6.4 ( KCNG4 ), Kv8.1 ( KCNV1 ), K …
Regulation of aberrantly expressed SERPINH1 by antitumor miR-148a-5p inhibits cancer cell aggressiveness in gastric cancer.
Kawagoe K, Wada M, Idichi T, Okada R, Yamada Y, Moriya S, Okubo K, Matsushita D, Arigami T, Kurahara H, Maemura K, Natsugoe S, Seki N. Kawagoe K, et al. J Hum Genet. 2020 Aug;65(8):647-656. doi: 10.1038/s10038-020-0746-6. Epub 2020 Mar 31. J Hum Genet. 2020. PMID: 32235846
Among these targets, high expression levels of six genes (THBS2, P4HA3, SERPINH1, CDH11, BCAT1, and KCNG3) were closely associated with a poor prognosis (10-year survival rates) in GC patients (p < 0.05) according to TCGA database analyses. ...
Among these targets, high expression levels of six genes (THBS2, P4HA3, SERPINH1, CDH11, BCAT1, and KCNG3) were closely associated wi …
DNA methylation biomarkers for lung cancer.
Rauch TA, Wang Z, Wu X, Kernstine KH, Riggs AD, Pfeifer GP. Rauch TA, et al. Tumour Biol. 2012 Apr;33(2):287-96. doi: 10.1007/s13277-011-0282-2. Epub 2011 Dec 6. Tumour Biol. 2012. PMID: 22143938
Using sodium-bisulfite-based approaches, 12 CpG islands (associated with the BARHL2, EVX2, IRX2, MEIS1, MSX1, NR2E1, OC2, OSR1, OTX1, PAX6, TFAP2A, and ZNF577 genes) were confirmed to be methylated in 85% to 100% of the squamous cell carcinomas and 11 CpG islands (associated with …
Using sodium-bisulfite-based approaches, 12 CpG islands (associated with the BARHL2, EVX2, IRX2, MEIS1, MSX1, NR2E1, OC2, OSR1, OTX1, PAX6, …
Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells.
Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX. Fantozzi I, et al. Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L993-1004. doi: 10.1152/ajplung.00191.2005. Epub 2006 Jun 30. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16815889 Free article.
BMP-2 (100 nM for 18-24 h) significantly (>2-fold) upregulated mRNA expression of KCNA5, KCNA7, KCNA10, KCNC3, KCNC4, KCNF1, KCNG3, KCNS1, and KCNS3 but downregulated (at least 2-fold) KCNAB1, KCNA2, KCNG2, and KCNV2. ...
BMP-2 (100 nM for 18-24 h) significantly (>2-fold) upregulated mRNA expression of KCNA5, KCNA7, KCNA10, KCNC3, KCNC4, KCNF1, KCNG3
Early onset schizophrenia: Gender analysis of genome-wide potential methylation.
Bani-Fatemi A, Zai C, De Luca V. Bani-Fatemi A, et al. Clin Chim Acta. 2015 Sep 20;449:63-7. doi: 10.1016/j.cca.2015.03.032. Epub 2015 Apr 1. Clin Chim Acta. 2015. PMID: 25840049
RESULTS: In the SNP-wise analysis, the top autosomal SNP was rs12619000 with 50% potential methylation in males and 95% in females (p=0.000008). In the gene-wise analysis, the KCNG3 was significantly associated with higher potential methylation in males (p=0.0004). ...
RESULTS: In the SNP-wise analysis, the top autosomal SNP was rs12619000 with 50% potential methylation in males and 95% in females (p=0.0000 …
Novel RNA biomarkers of prostate cancer revealed by RNA-seq analysis of formalin-fixed samples obtained from Russian patients.
Nikitina AS, Sharova EI, Danilenko SA, Butusova TB, Vasiliev AO, Govorov AV, Prilepskaya EA, Pushkar DY, Kostryukova ES. Nikitina AS, et al. Oncotarget. 2017 May 16;8(20):32990-33001. doi: 10.18632/oncotarget.16518. Oncotarget. 2017. PMID: 28380430 Free PMC article.
Overexpression of four of the discovered genes (ANKRD34B, NEK5, KCNG3, and PTPRT) was validated by RT-qPCR. Furthermore, the enrichment analysis of overrepresented microRNA and transcription factor (TF) recognition sites within DE genes revealed common regulatory elements …
Overexpression of four of the discovered genes (ANKRD34B, NEK5, KCNG3, and PTPRT) was validated by RT-qPCR. Furthermore, the enrichme …
De novo expression of Kv6.3 contributes to changes in vascular smooth muscle cell excitability in a hypertensive mice strain.
Moreno-Domínguez A, Cidad P, Miguel-Velado E, López-López JR, Pérez-García MT. Moreno-Domínguez A, et al. J Physiol. 2009 Feb 1;587(3):625-40. doi: 10.1113/jphysiol.2008.165217. Epub 2008 Dec 15. J Physiol. 2009. PMID: 19074965 Free PMC article.
In mesenteric arteries, the most conspicuous change was the de novo expression of Kv6.3 (Kcng3) mRNA in hypertensive animals. The functional relevance of this change was studied by using patch-clamp techniques. ...
In mesenteric arteries, the most conspicuous change was the de novo expression of Kv6.3 (Kcng3) mRNA in hypertensive animals. The fun …
17 results