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Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification.
Kampstra ASB, Dekkers JS, Volkov M, Dorjée AL, Hafkenscheid L, Kempers AC, van Delft M, Kissel T, Reijm S, Janssen GMC, van Veelen PA, Bang H, Huizinga TWJ, Trouw LA, van der Woude D, Toes REM. Kampstra ASB, et al. Among authors: kempers ac. Ann Rheum Dis. 2019 Jul;78(7):908-916. doi: 10.1136/annrheumdis-2018-214950. Epub 2019 May 31. Ann Rheum Dis. 2019. PMID: 31151934
Synovial fluid mononuclear cells provide an environment for long-term survival of antibody-secreting cells and promote the spontaneous production of anti-citrullinated protein antibodies.
Kerkman PF, Kempers AC, van der Voort EI, van Oosterhout M, Huizinga TW, Toes RE, Scherer HU. Kerkman PF, et al. Among authors: kempers ac. Ann Rheum Dis. 2016 Dec;75(12):2201-2207. doi: 10.1136/annrheumdis-2015-208554. Epub 2016 Apr 11. Ann Rheum Dis. 2016. PMID: 27069015