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Year Number of Results
2009 1
2014 1
2015 1
2016 1
2018 6
2019 1
2020 3
2021 2
2022 2
2023 3
2024 0

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18 results

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Page 1
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.
Vuckovic Z, Wang J, Pham V, Mobbs JI, Belousoff MJ, Bhattarai A, Burger WAC, Thompson G, Yeasmin M, Nawaratne V, Leach K, van der Westhuizen ET, Khajehali E, Liang YL, Glukhova A, Wootten D, Lindsley CW, Tobin A, Sexton P, Danev R, Valant C, Miao Y, Christopoulos A, Thal DM. Vuckovic Z, et al. Among authors: khajehali e. Elife. 2023 May 30;12:e83477. doi: 10.7554/eLife.83477. Elife. 2023. PMID: 37248726 Free PMC article.
M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease.
Dwomoh L, Rossi M, Scarpa M, Khajehali E, Molloy C, Herzyk P, Mistry SN, Bottrill AR, Sexton PM, Christopoulos A, Conn J, Lindsley CW, Bradley SJ, Tobin AB. Dwomoh L, et al. Among authors: khajehali e. Sci Signal. 2022 Nov 15;15(760):eabm3720. doi: 10.1126/scisignal.abm3720. Epub 2022 Nov 15. Sci Signal. 2022. PMID: 36378750 Free PMC article.
Dual Action Calcium-Sensing Receptor Modulator Unmasks Novel Mode-Switching Mechanism.
Gregory KJ, Kufareva I, Keller AN, Khajehali E, Mun HC, Goolam MA, Mason RS, Capuano B, Conigrave AD, Christopoulos A, Leach K. Gregory KJ, et al. Among authors: khajehali e. ACS Pharmacol Transl Sci. 2018 Sep 12;1(2):96-109. doi: 10.1021/acsptsci.8b00021. eCollection 2018 Nov 9. ACS Pharmacol Transl Sci. 2018. PMID: 32219206 Free PMC article.
Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.
Jörg M, Khajehali E, van der Westhuizen ET, C Choy KH, Shackleford DM, Tobin AB, Sexton PM, Valant C, Capuano B, Christopoulos A, Scammells PJ. Jörg M, et al. Among authors: khajehali e. ChemMedChem. 2021 Jan 8;16(1):216-233. doi: 10.1002/cmdc.202000540. Epub 2020 Sep 25. ChemMedChem. 2021. PMID: 32851779 Free PMC article.
Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.
Jörg M, van der Westhuizen ET, Lu Y, Christopher Choy KH, Shackleford DM, Khajehali E, Tobin AB, Thal DM, Capuano B, Christopoulos A, Valant C, Scammells PJ. Jörg M, et al. Among authors: khajehali e. Eur J Med Chem. 2023 Oct 5;258:115588. doi: 10.1016/j.ejmech.2023.115588. Epub 2023 Jul 1. Eur J Med Chem. 2023. PMID: 37423123 Free PMC article.
6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity.
Jörg M, van der Westhuizen ET, Khajehali E, Burger WAC, White JM, Choy KHC, Tobin AB, Sexton PM, Valant C, Capuano B, Christopoulos A, Scammells PJ. Jörg M, et al. Among authors: khajehali e. ACS Chem Neurosci. 2019 Mar 20;10(3):1099-1114. doi: 10.1021/acschemneuro.8b00613. Epub 2018 Dec 28. ACS Chem Neurosci. 2019. PMID: 30547573 Free PMC article.
18 results