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Plight of the pore polar bar(rier).

Denton JS, Kharade SV. Denton JS, et al. Among authors: kharade sv. Channels (Austin). 2017 Nov 2;11(6):502-503. doi: 10.1080/19336950.2017.1367234. Epub 2017 Aug 25. Channels (Austin). 2017. PMID: 28806132 Free PMC article. No abstract available.

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The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics.

Kharade SV, Nichols C, Denton JS. Kharade SV, et al. Future Med Chem. 2016 May;8(7):789-802. doi: 10.4155/fmc-2016-0005. Epub 2016 May 10. Future Med Chem. 2016. PMID: 27161588 Free PMC article. Review.

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Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.

Sammons MF, Kharade SV, Filipski KJ, Boehm M, Smith AC, Shavnya A, Fernando DP, Dowling MS, Carpino PA, Castle NA, Zellmer SG, Antonio BM, Gosset JR, Carlo A, Denton JS. Sammons MF, et al. Among authors: kharade sv. ACS Med Chem Lett. 2018 Jan 19;9(2):125-130. doi: 10.1021/acsmedchemlett.7b00481. eCollection 2018 Feb 8. ACS Med Chem Lett. 2018. PMID: 29456800 Free PMC article.

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Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides.

Aretz CD, Kharade SV, Chronister K, Rusconi Trigueros R, Martinez Rodriguez EJ, Piermarini PM, Denton JS, Hopkins CR. Aretz CD, et al. Among authors: kharade sv. ChemMedChem. 2021 Jan 19;16(2):319-327. doi: 10.1002/cmdc.202000598. Epub 2020 Oct 28. ChemMedChem. 2021. PMID: 32926544 Free PMC article.

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Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.

Swale DR, Kharade SV, Denton JS. Swale DR, et al. Among authors: kharade sv. Curr Opin Pharmacol. 2014 Apr;15:7-15. doi: 10.1016/j.coph.2013.11.002. Epub 2013 Nov 26. Curr Opin Pharmacol. 2014. PMID: 24721648 Free PMC article. Review.

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ROMK (Kir1.1) pharmacology comes of age.

Kharade SV, Swale DR, Denton JS. Kharade SV, et al. Channels (Austin). 2015;9(3):119-20. doi: 10.1080/19336950.2015.1046733. Channels (Austin). 2015. PMID: 25941772 Free PMC article. No abstract available.

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Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063.

Kharade SV, Sanchez-Andres JV, Fulton MG, Shelton EL, Blobaum AL, Engers DW, Hofmann CS, Dadi PK, Lantier L, Jacobson DA, Lindsley CW, Denton JS. Kharade SV, et al. J Pharmacol Exp Ther. 2019 Sep;370(3):350-359. doi: 10.1124/jpet.119.257204. Epub 2019 Jun 14. J Pharmacol Exp Ther. 2019. PMID: 31201216 Free PMC article.

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ROMK inhibitor actions in the nephron probed with diuretics.

Kharade SV, Flores D, Lindsley CW, Satlin LM, Denton JS. Kharade SV, et al. Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F732-F737. doi: 10.1152/ajprenal.00423.2015. Epub 2015 Dec 9. Am J Physiol Renal Physiol. 2016. PMID: 26661652 Free PMC article.

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The LRRC8 volume-regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel.

Afzal A, Figueroa EE, Kharade SV, Bittman K, Matlock BK, Flaherty DK, Denton JS. Afzal A, et al. Among authors: kharade sv. Physiol Rep. 2019 Dec;7(23):e14303. doi: 10.14814/phy2.14303. Physiol Rep. 2019. PMID: 31814333 Free PMC article.

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Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 ( AeKir1) Channel.

Aretz CD, Morwitzer MJ, Sanford AG, Hogan AM, Portillo MV, Kharade SV, Kramer M, McCarthey JB, Trigueros RR, Piermarini PM, Denton JS, Hopkins CR. Aretz CD, et al. Among authors: kharade sv. ACS Infect Dis. 2019 Jun 14;5(6):917-931. doi: 10.1021/acsinfecdis.8b00368. Epub 2019 Mar 15. ACS Infect Dis. 2019. PMID: 30832472 Free PMC article.

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