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78 results

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Page 1
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K. Wang Y, et al. Among authors: kharas mg. Nature. 2021 Nov;599(7883):136-140. doi: 10.1038/s41586-021-04025-w. Epub 2021 Oct 27. Nature. 2021. PMID: 34707288 Free PMC article.
Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells.
Park SM, Miyamoto DK, Han GYQ, Chan M, Curnutt NM, Tran NL, Velleca A, Kim JH, Schurer A, Chang K, Xu W, Kharas MG, Woo CM. Park SM, et al. Among authors: kharas mg. Cancer Cell. 2023 Apr 10;41(4):726-739.e11. doi: 10.1016/j.ccell.2023.02.010. Epub 2023 Mar 9. Cancer Cell. 2023. PMID: 36898380 Free PMC article.
BTG1 mutation yields supercompetitive B cells primed for malignant transformation.
Mlynarczyk C, Teater M, Pae J, Chin CR, Wang L, Arulraj T, Barisic D, Papin A, Hoehn KB, Kots E, Ersching J, Bandyopadhyay A, Barin E, Poh HX, Evans CM, Chadburn A, Chen Z, Shen H, Isles HM, Pelzer B, Tsialta I, Doane AS, Geng H, Rehman MH, Melnick J, Morgan W, Nguyen DTT, Elemento O, Kharas MG, Jaffrey SR, Scott DW, Khelashvili G, Meyer-Hermann M, Victora GD, Melnick A. Mlynarczyk C, et al. Among authors: kharas mg. Science. 2023 Jan 20;379(6629):eabj7412. doi: 10.1126/science.abj7412. Epub 2023 Jan 20. Science. 2023. PMID: 36656933 Free PMC article.
Dotting Out AML by Targeting Fibrillarin.
Luo H, Kharas MG. Luo H, et al. Among authors: kharas mg. Cancer Res. 2024 Sep 4;84(17):2759-2760. doi: 10.1158/0008-5472.CAN-24-2125. Cancer Res. 2024. PMID: 38924716 Review.
IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation.
Park SM, Cho H, Thornton AM, Barlowe TS, Chou T, Chhangawala S, Fairchild L, Taggart J, Chow A, Schurer A, Gruet A, Witkin MD, Kim JH, Shevach EM, Krivtsov A, Armstrong SA, Leslie C, Kharas MG. Park SM, et al. Among authors: kharas mg. Cell Stem Cell. 2019 Jan 3;24(1):153-165.e7. doi: 10.1016/j.stem.2018.10.016. Epub 2018 Nov 21. Cell Stem Cell. 2019. PMID: 30472158 Free PMC article.
SON is an essential m6A target for hematopoietic stem cell fate.
Luo H, Cortés-López M, Tam CL, Xiao M, Wakiro I, Chu KL, Pierson A, Chan M, Chang K, Yang X, Fecko D, Han G, Ahn EE, Morris QD, Landau DA, Kharas MG. Luo H, et al. Among authors: kharas mg. Cell Stem Cell. 2023 Dec 7;30(12):1658-1673.e10. doi: 10.1016/j.stem.2023.11.006. Cell Stem Cell. 2023. PMID: 38065069 Free PMC article.
Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia.
Kotini AG, Carcamo S, Cruz-Rodriguez N, Olszewska M, Wang T, Demircioglu D, Chang CJ, Bernard E, Chao MP, Majeti R, Luo H, Kharas MG, Hasson D, Papapetrou EP. Kotini AG, et al. Among authors: kharas mg. Blood Cancer Discov. 2023 Jul 5;4(4):318-335. doi: 10.1158/2643-3230.BCD-22-0167. Blood Cancer Discov. 2023. PMID: 37067914 Free PMC article.
RNA Regulators in Leukemia and Lymphoma.
Prieto C, Kharas MG. Prieto C, et al. Among authors: kharas mg. Cold Spring Harb Perspect Med. 2020 May 1;10(5):a034967. doi: 10.1101/cshperspect.a034967. Cold Spring Harb Perspect Med. 2020. PMID: 31615866 Free PMC article. Review.
Design and Development of IKZF2 and CK1α Dual Degraders.
Miyamoto DK, Curnutt NM, Park SM, Stavropoulos A, Kharas MG, Woo CM. Miyamoto DK, et al. Among authors: kharas mg. J Med Chem. 2023 Dec 28;66(24):16953-16979. doi: 10.1021/acs.jmedchem.3c01736. Epub 2023 Dec 12. J Med Chem. 2023. PMID: 38085607 Free PMC article.
78 results