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CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide.
Gurney M, Stikvoort A, Nolan E, Kirkham-McCarthy L, Khoruzhenko S, Shivakumar R, Zweegman S, Van de Donk NWCJ, Mutis T, Szegezdi E, Sarkar S, O'Dwyer M. Gurney M, et al. Among authors: khoruzhenko s. Haematologica. 2022 Feb 1;107(2):437-445. doi: 10.3324/haematol.2020.271908. Haematologica. 2022. PMID: 33375774 Free PMC article.
Short peptide sequences mimic HLA-DM functions.
Chou CL, Mirshahidi S, Su KW, Kim A, Narayan K, Khoruzhenko S, Xu M, Sadegh-Nasseri S. Chou CL, et al. Among authors: khoruzhenko s. Mol Immunol. 2008 Apr;45(7):1935-43. doi: 10.1016/j.molimm.2007.10.033. Epub 2007 Dec 3. Mol Immunol. 2008. PMID: 18054387