Kilford PJ[au] - Search Results

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Year	Number of Results
2007	1
2008	4
2009	1
2022	2

Page 1

Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.

Kilford PJ, Chen KF, Crewe K, Gardner I, Hatley O, Ke AB, Neuhoff S, Zhang M, Rowland Yeo K. Kilford PJ, et al. CPT Pharmacometrics Syst Pharmacol. 2022 Apr 20. doi: 10.1002/psp4.12794. Online ahead of print. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35445542 Free article.

Toward an improved prediction of human in vivo brain penetration.

Summerfield SG, Lucas AJ, Porter RA, Jeffrey P, Gunn RN, Read KR, Stevens AJ, Metcalf AC, Osuna MC, Kilford PJ, Passchier J, Ruffo AD. Summerfield SG, et al. Among authors: kilford pj. Xenobiotica. 2008 Dec;38(12):1518-35. doi: 10.1080/00498250802499459. Xenobiotica. 2008. PMID: 18979396

A Mechanistic Absorption and Disposition Model of Ritonavir to Predict Exposure and Drug-Drug Interaction Potential of CYP3A4/5 and CYP2D6 Substrates.

Arora S, Pansari A, Kilford PJ, Jamei M, Turner DB, Gardner I. Arora S, et al. Among authors: kilford pj. Eur J Drug Metab Pharmacokinet. 2022 Apr 29. doi: 10.1007/s13318-022-00765-w. Online ahead of print. Eur J Drug Metab Pharmacokinet. 2022. PMID: 35486324

Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data.

Kilford PJ, Gertz M, Houston JB, Galetin A. Kilford PJ, et al. Drug Metab Dispos. 2008 Jul;36(7):1194-7. doi: 10.1124/dmd.108.020834. Epub 2008 Apr 14. Drug Metab Dispos. 2008. PMID: 18411401

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.

Kilford PJ, Stringer R, Sohal B, Houston JB, Galetin A. Kilford PJ, et al. Drug Metab Dispos. 2009 Jan;37(1):82-9. doi: 10.1124/dmd.108.023853. Epub 2008 Oct 2. Drug Metab Dispos. 2009. PMID: 18832476

Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations.

Gertz M, Kilford PJ, Houston JB, Galetin A. Gertz M, et al. Among authors: kilford pj. Drug Metab Dispos. 2008 Mar;36(3):535-42. doi: 10.1124/dmd.107.018713. Epub 2007 Dec 20. Drug Metab Dispos. 2008. PMID: 18096674

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