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Year Number of Results
2014 1
2016 1
2017 2
2018 2
2019 1
2020 1
2021 2
2022 0
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10 results
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Page 1
Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction.
Kinnunen SM, Tölli M, Välimäki MJ, Gao E, Szabo Z, Rysä J, Ferreira MPA, Ohukainen P, Serpi R, Correia A, Mäkilä E, Salonen J, Hirvonen J, Santos HA, Ruskoaho H. Kinnunen SM, et al. Sci Rep. 2018 Mar 15;8(1):4611. doi: 10.1038/s41598-018-22830-8. Sci Rep. 2018. PMID: 29545582 Free PMC article.
Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators.
Jumppanen M, Kinnunen SM, Välimäki MJ, Talman V, Auno S, Bruun T, Boije Af Gennäs G, Xhaard H, Aumüller IB, Ruskoaho H, Yli-Kauhaluoma J. Jumppanen M, et al. Among authors: kinnunen sm. J Med Chem. 2019 Sep 12;62(17):8284-8310. doi: 10.1021/acs.jmedchem.9b01086. Epub 2019 Sep 3. J Med Chem. 2019. PMID: 31431011 Free PMC article.
GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes.
Karhu ST, Kinnunen SM, Tölli M, Välimäki MJ, Szabó Z, Talman V, Ruskoaho H. Karhu ST, et al. Among authors: kinnunen sm. Arch Toxicol. 2020 Jun;94(6):2113-2130. doi: 10.1007/s00204-020-02711-8. Epub 2020 Mar 17. Arch Toxicol. 2020. PMID: 32185414 Free PMC article.
Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.
Karhu ST, Välimäki MJ, Jumppanen M, Kinnunen SM, Pohjolainen L, Leigh RS, Auno S, Földes G, Boije Af Gennäs G, Yli-Kauhaluoma J, Ruskoaho H, Talman V. Karhu ST, et al. Among authors: kinnunen sm. Arch Toxicol. 2018 Sep;92(9):2897-2911. doi: 10.1007/s00204-018-2257-1. Epub 2018 Jul 9. Arch Toxicol. 2018. PMID: 29987409 Free PMC article.
In vitro and in vivo assessment of heart-homing porous silicon nanoparticles.
Ferreira MP, Ranjan S, Correia AM, Mäkilä EM, Kinnunen SM, Zhang H, Shahbazi MA, Almeida PV, Salonen JJ, Ruskoaho HJ, Airaksinen AJ, Hirvonen JT, Santos HA. Ferreira MP, et al. Among authors: kinnunen sm. Biomaterials. 2016 Jul;94:93-104. doi: 10.1016/j.biomaterials.2016.03.046. Epub 2016 Apr 11. Biomaterials. 2016. PMID: 27107168
In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart.
Tölli MA, Ferreira MP, Kinnunen SM, Rysä J, Mäkilä EM, Szabó Z, Serpi RE, Ohukainen PJ, Välimäki MJ, Correia AM, Salonen JJ, Hirvonen JT, Ruskoaho HJ, Santos HA. Tölli MA, et al. Among authors: kinnunen sm. Biomaterials. 2014 Sep;35(29):8394-405. doi: 10.1016/j.biomaterials.2014.05.078. Epub 2014 Jun 28. Biomaterials. 2014. PMID: 24985734