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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
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1982 1
1985 1
1989 1
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1994 1
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1998 2
2000 3
2003 3
2004 3
2005 3
2006 5
2007 7
2008 7
2009 5
2010 5
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2012 27
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593 results

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Page 1
KLB dysregulation mediates disrupted muscle development in intrauterine growth restriction.
Cortes-Araya Y, Stenhouse C, Salavati M, Dan-Jumbo SO, Ho W, Ashworth CJ, Clark E, Esteves CL, Donadeu FX. Cortes-Araya Y, et al. J Physiol. 2022 Apr;600(7):1771-1790. doi: 10.1113/JP281647. Epub 2022 Feb 17. J Physiol. 2022. PMID: 35081669 Free PMC article.
In conclusion, our results identify KLB as a novel and potentially critical mediator of impaired muscle development in IUGR, through conserved mechanisms in pigs and humans. ...KLB mediates a reduction in muscle development through inhibition of mechanistic target o …
In conclusion, our results identify KLB as a novel and potentially critical mediator of impaired muscle development in IUGR, through …
Metabolic Messengers: FGF21.
Flippo KH, Potthoff MJ. Flippo KH, et al. Nat Metab. 2021 Mar;3(3):309-317. doi: 10.1038/s42255-021-00354-2. Epub 2021 Mar 18. Nat Metab. 2021. PMID: 33758421 Free PMC article. Review.
β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130.
Geng L, Liao B, Jin L, Yu J, Zhao X, Zhao Y, Zhong L, Wang B, Li J, Liu J, Yang JK, Jia W, Lian Q, Xu A. Geng L, et al. Nat Metab. 2022 May;4(5):608-626. doi: 10.1038/s42255-022-00572-2. Epub 2022 May 12. Nat Metab. 2022. PMID: 35551509
However, cellular signaling machineries that control GSIS remain incompletely understood. Here, we report that beta-klotho (KLB), a single-pass transmembrane protein known as a co-receptor for fibroblast growth factor 21 (FGF21), fine tunes GSIS via modulation of glycolysi …
However, cellular signaling machineries that control GSIS remain incompletely understood. Here, we report that beta-klotho (KLB), a s …
Epigenetic Regulation of Hepatic Lipid Metabolism by DNA Methylation.
Wang S, Zha L, Cui X, Yeh YT, Liu R, Jing J, Shi H, Chen W, Hanover J, Yin J, Yu L, Xue B, Shi H. Wang S, et al. Adv Sci (Weinh). 2023 Jul;10(20):e2206068. doi: 10.1002/advs.202206068. Epub 2023 Jun 6. Adv Sci (Weinh). 2023. PMID: 37282749 Free PMC article.
Targeted demethylation at the Klb promoter increases Klb expression and fatty acid oxidation, resulting in decreased hepatic lipid accumulation. Up-regulation of methyltransferases by HFD may induce hypermethylation of the Klb promoter and subsequent down-reg …
Targeted demethylation at the Klb promoter increases Klb expression and fatty acid oxidation, resulting in decreased hepatic l …
Aberrant acetylated modification of FGF21-KLB signaling contributes to hepatocellular carcinoma metastasis through the beta-catenin pathway.
Xia J, Zhu Z, Wen G, Chen Y, An R, Xia S, Guan W, Ren H. Xia J, et al. Int J Oncol. 2023 Aug;63(2):91. doi: 10.3892/ijo.2023.5539. Epub 2023 Jun 23. Int J Oncol. 2023. PMID: 37350415
In addition, KLB expression was closely associated with HCC metastasis. Migration and invasion assays revealed that KLB knockdown promoted the metastatic capability of HCC cells. ...In conclusion, the present study demonstrated that aberrant acetylated modification …
In addition, KLB expression was closely associated with HCC metastasis. Migration and invasion assays revealed that KLB knockd …
FGF21 in obesity and cancer: New insights.
Lu W, Li X, Luo Y. Lu W, et al. Cancer Lett. 2021 Feb 28;499:5-13. doi: 10.1016/j.canlet.2020.11.026. Epub 2020 Nov 29. Cancer Lett. 2021. PMID: 33264641 Free PMC article. Review.
The white and brown adipose tissues and, to some extent, the hypothalamus, all of which host a transmembrane receptor binary complex of FGFR1 and co-receptor KLB, are considered the essential tissue and molecular targets of hepatic or pharmacological FGF21. ...This review …
The white and brown adipose tissues and, to some extent, the hypothalamus, all of which host a transmembrane receptor binary complex of FGFR …
KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese.
Ji F, Liu Y, Hao JG, Wang LP, Dai MJ, Shen GF, Yan XB. Ji F, et al. Aging (Albany NY). 2019 Sep 23;11(18):7847-7858. doi: 10.18632/aging.102293. Epub 2019 Sep 23. Aging (Albany NY). 2019. PMID: 31548436 Free PMC article.
Klotho beta (KLB) mediates binding of fibroblast growth factor (FGF) 21 to the FGF receptor (FGFR). FGF21-KLB-FGFR signaling regulates multiple metabolic systems in the liver, and we hypothesized that FGF21, KLB and FGFR single-nucleotide polymorphisms (SNPs) …
Klotho beta (KLB) mediates binding of fibroblast growth factor (FGF) 21 to the FGF receptor (FGFR). FGF21-KLB-FGFR signaling r …
Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis.
Guo W, Cao H, Shen Y, Li W, Wang W, Cheng L, Cai M, Xu F. Guo W, et al. Nutr Diabetes. 2024 Apr 12;14(1):18. doi: 10.1038/s41387-024-00277-3. Nutr Diabetes. 2024. PMID: 38609395 Free PMC article.
FGF21 conventionally initiates its intracellular signaling via receptor beta-klotho (KLB). However, the mechanistic role of FGF21-KLB signaling for KD-ameliorated fatty liver remains unknown. ...Transcriptional analysis revealed that KD dramatically activated FGF21 …
FGF21 conventionally initiates its intracellular signaling via receptor beta-klotho (KLB). However, the mechanistic role of FGF21- …
KLB and NOX4 expression levels as potential blood-based transcriptional biomarkers of physical activity in children.
Galmés S, Rupérez AI, Sánchez J, Moreno LA, Foraita R, Hebestreit A, Molnár D, Palou A, Picó C. Galmés S, et al. Sci Rep. 2023 Apr 5;13(1):5563. doi: 10.1038/s41598-023-31537-4. Sci Rep. 2023. PMID: 37019912 Free PMC article.

A set of genes differentially expressed (p < 0.01, Limma test) in less physically active children were identified, including the down-regulation of genes related to cardiometabolic benefits and improved skeletal function (KLB, NOX4, and SYPL2), and the up-regulation of

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A set of genes differentially expressed (p < 0.01, Limma test) in less physically active children were identified, including the down-reg

…
593 results