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Page 1
KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease.
Rah G, Cha H, Kim J, Song J, Kim H, Oh YK, Ahn C, Kang M, Kim J, Yoo KH, Kim MJ, Ko HW, Ko JY, Park JH. Rah G, et al. J Am Soc Nephrol. 2022 Sep;33(9):1726-1741. doi: 10.1681/ASN.2021111455. Epub 2022 Aug 12. J Am Soc Nephrol. 2022. PMID: 35961787 Free PMC article.
KLC3 interacts with CILK1 at cilia bases and is increased in cyst-lining cells of CILK1-deficient mice. ...Reduction in KLC3 rescued the ciliary defects and inhibited cyst progression caused by CILK1 deficiency. ...
KLC3 interacts with CILK1 at cilia bases and is increased in cyst-lining cells of CILK1-deficient mice. ...Reduction in KLC3 r …
KLC3 activates PI3K/AKT signaling and promotes ovarian cancer cell proliferation and migration through COL3A1.
Yang J, He R, Zhang X, Wang X, Liu M, Liu X, Li Y. Yang J, et al. Oncol Rep. 2025 Jun;53(6):67. doi: 10.3892/or.2025.8900. Epub 2025 Apr 17. Oncol Rep. 2025. PMID: 40242978 Free PMC article.
Ovarian cancer (OC) is a prevalent malignancy; however, the role of kinesin light chain 3 (KLC3) in OC remains unclear. The present study conducted a comprehensive investigation of KLC3 using bioinformatics analysis, as well as in vitro and in vivo experiments. The …
Ovarian cancer (OC) is a prevalent malignancy; however, the role of kinesin light chain 3 (KLC3) in OC remains unclear. The present s …
Kinesins in spermatogenesis.
Ma DD, Wang DH, Yang WX. Ma DD, et al. Biol Reprod. 2017 Feb 1;96(2):267-276. doi: 10.1095/biolreprod.116.144113. Biol Reprod. 2017. PMID: 28203733 Review.
In this process, KIFC1, KIF5C, KRP3A, and KRP3B may be involved in acrosome biogenesis; KIFC1, KIFC5, CHO2, KIF17b, and KIF3A probably contribute to nuclear shaping; KIF17b, KIF3A, and KLC3 are implicated in the tail formation process; and KIF20 and KRP3 likely participate …
In this process, KIFC1, KIF5C, KRP3A, and KRP3B may be involved in acrosome biogenesis; KIFC1, KIFC5, CHO2, KIF17b, and KIF3A probably contr …
KLC3 is involved in sperm tail midpiece formation and sperm function.
Zhang Y, Ou Y, Cheng M, Saadi HS, Thundathil JC, van der Hoorn FA. Zhang Y, et al. Dev Biol. 2012 Jun 15;366(2):101-10. doi: 10.1016/j.ydbio.2012.04.026. Epub 2012 Apr 27. Dev Biol. 2012. PMID: 22561200 Free article.
Kinesin light chain 3 (KLC3) is the only known kinesin light chain expressed in post-meiotic male germ cells. ...In fibroblasts, expression of KLC3 results in formation of large KLC3 aggregates close to the nucleus that contain mitochondria. ...
Kinesin light chain 3 (KLC3) is the only known kinesin light chain expressed in post-meiotic male germ cells. ...In fibroblasts, expr …
Altered expression of KLC3 may affect semen parameters.
Kargar-Dastjerdy P, Tavalaee M, Salehi M, Falahati M, Izadi T, Nasr Esfahani MH. Kargar-Dastjerdy P, et al. Int J Reprod Biomed. 2016 Jan;14(1):15-22. Int J Reprod Biomed. 2016. PMID: 27141544 Free PMC article.
A significant correlation was not found between KLC3 expression and sperm motility; however, the relative expression of KLC3 was significantly higher in asthenozoospermic compared to non-asthenozoospermic individuals. CONCLUSION: Low expression of KLC3 may re …
A significant correlation was not found between KLC3 expression and sperm motility; however, the relative expression of KLC3 w …
NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis.
Bi X, Zhang Q, Chen L, Liu D, Li Y, Zhao X, Zhang Y, Zhang L, Liu J, Wu C, Li Z, Zhao Y, Ma H, Huang G, Liu X, Wang QF, Zhang R. Bi X, et al. J Hematol Oncol. 2022 Jul 28;15(1):101. doi: 10.1186/s13045-022-01318-z. J Hematol Oncol. 2022. PMID: 35902954 Free PMC article.
Additionally, two candidate genes, RAB9B and KLC3, showed a direct relationship with known HLH genes in protein-protein interaction (PPI) network analysis. We analyzed NBAS, RAB9B, KLC3 and known HLH genes in an independent validation cohort of 224 pediatric HLH pat …
Additionally, two candidate genes, RAB9B and KLC3, showed a direct relationship with known HLH genes in protein-protein interaction ( …
Kinesin light-chain KLC3 expression in testis is restricted to spermatids.
Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA. Junco A, et al. Biol Reprod. 2001 May;64(5):1320-30. doi: 10.1095/biolreprod64.5.1320. Biol Reprod. 2001. PMID: 11319135 Free PMC article.
We report the cloning from a testicular cDNA expression library of a mammalian light chain, KLC3. The KLC3 gene is located in close proximity to the ERCC2 gene. KLC3 can be classified as a genuine light chain: it interacts in vitro with the KHC, the interacti …
We report the cloning from a testicular cDNA expression library of a mammalian light chain, KLC3. The KLC3 gene is located in …
Rat kinesin light chain 3 associates with spermatid mitochondria.
Zhang Y, Oko R, van der Hoorn FA. Zhang Y, et al. Dev Biol. 2004 Nov 1;275(1):23-33. doi: 10.1016/j.ydbio.2004.07.014. Dev Biol. 2004. PMID: 15464570 Free PMC article.
Expression of KLC3 in fibroblasts results in formation of large KLC3 clusters close to the nucleus, which also contain mitochondria: no other organelles were present in these clusters. Mitochondria are not present in KLC3 clusters after deletion of KLC3 …
Expression of KLC3 in fibroblasts results in formation of large KLC3 clusters close to the nucleus, which also contain mitocho …
Somatic mutational landscape across Indian breast cancer cases by whole exome sequencing.
Kumar R, Awasthi S, Pradhan D, Kumar R, Goel H, Singh J, Haider I, Deo SVS, Kumar C, Srivastava A, Bhatnagar A, Kumar R, Lakshmi S, Augustine P, Ranjan A, Chopra A, Gogia A, Batra A, Mathur S, Rath GK, Kaur T, Dhaliwal RS, Mathew A, Agrawal U, Hussain S, Tanwar P. Kumar R, et al. Sci Rep. 2024 Aug 12;14(1):18679. doi: 10.1038/s41598-024-65148-4. Sci Rep. 2024. PMID: 39134585 Free PMC article.
TTN, TP53, MUC16, SYNE1, and OBSCN were the frequently altered genes found in our cohort. The PIK3CA and KLC3 genes are driver genes implicated in various cellular functions and cargo transportation through microtubules, respectively. ...
TTN, TP53, MUC16, SYNE1, and OBSCN were the frequently altered genes found in our cohort. The PIK3CA and KLC3 genes are driver genes …
Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion.
Bhullar B, Zhang Y, Junco A, Oko R, van der Hoorn FA. Bhullar B, et al. J Biol Chem. 2003 May 2;278(18):16159-68. doi: 10.1074/jbc.M213126200. Epub 2003 Feb 19. J Biol Chem. 2003. PMID: 12594206 Free PMC article.
No significant binding of KLC3 with microtubules was observed with this monoclonal antibody. In vitro experiments showed that KLC3-ODF binding occurred in the absence of kinesin heavy chains or microtubules and required the KLC3 HR. ODF1, a major ODF protein, …
No significant binding of KLC3 with microtubules was observed with this monoclonal antibody. In vitro experiments showed that KLC3 …
28 results