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KLC4 shapes axon arbors during development and mediates adult behavior.
Haynes EM, Burnett KH, He J, Jean-Pierre MW, Jarzyna M, Eliceiri KW, Huisken J, Halloran MC. Haynes EM, et al. Elife. 2022 Oct 12;11:e74270. doi: 10.7554/eLife.74270. Elife. 2022. PMID: 36222498 Free PMC article.
Using live imaging approaches in klc4 mutant zebrafish, we show that KLC4 is required for stabilization of nascent axon branches, proper microtubule (MT) dynamics, and endosomal transport. Furthermore, KLC4 is required for proper tiling of peripheral axon arb …
Using live imaging approaches in klc4 mutant zebrafish, we show that KLC4 is required for stabilization of nascent axon branch …
Hereditary Spastic Paraplegia Overview.
Hedera P. Hedera P. 2000 Aug 15 [updated 2021 Feb 11]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2000 Aug 15 [updated 2021 Feb 11]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301682 Free Books & Documents. Review.
A humanized Caenorhabditis elegans model of hereditary spastic paraplegia-associated variants in KLC4.
Gümüşderelioğlu S, Resch L, Brock T; Undiagnosed Diseases Network; Luxton GWG, Cope H, Tan QK, Hopkins C, Starr DA. Gümüşderelioğlu S, et al. Dis Model Mech. 2023 Aug 1;16(8):dmm050076. doi: 10.1242/dmm.050076. Epub 2023 Aug 29. Dis Model Mech. 2023. PMID: 37565267 Free PMC article.
We identified a variant in human kinesin light chain 4 (KLC4) that is suspected to be associated with autosomal-dominant HSP. How this and other variants relate to pathologies is unknown. We created a humanized Caenorhabditis elegans model in which klc-2 was replaced by hu …
We identified a variant in human kinesin light chain 4 (KLC4) that is suspected to be associated with autosomal-dominant HSP. How thi …
SETD3 reduces KLC4 expression to improve the sensitization of cervical cancer cell to radiotherapy.
Li Q, Zhang Y, Jiang Q. Li Q, et al. Biochem Biophys Res Commun. 2019 Aug 27;516(3):619-625. doi: 10.1016/j.bbrc.2019.06.058. Epub 2019 Jun 22. Biochem Biophys Res Commun. 2019. PMID: 31235251
In addition, we found that SETD3 down-regulated the expression of kinesin light chain 4 (KLC4), contributing to the radiosensitivity of cervical cancer cells, and the regulatory role of SETD3 could be abolished by KLC4 over-expression. ...
In addition, we found that SETD3 down-regulated the expression of kinesin light chain 4 (KLC4), contributing to the radiosensitivity …
A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4.
Gümüşderelioğlu S, Resch L, Brock T; Undiagnosed Diseases Network; Luxton GWG, Tan QK, Hopkins C, Starr DA. Gümüşderelioğlu S, et al. bioRxiv [Preprint]. 2023 Jan 8:2023.01.07.523106. doi: 10.1101/2023.01.07.523106. bioRxiv. 2023. Update in: Dis Model Mech. 2023 Aug 1;16(8):dmm050076. doi: 10.1242/dmm.050076 PMID: 36789438 Free PMC article. Updated. Preprint.
Thus, we were able to establish humanized C. elegans as an animal model for HSP and use it to test the significance of five variants of uncertain significance in the human gene KLC4 . SUMMARY STATEMENT: We identified a variant in KLC4 associated with Hereditary Spas …
Thus, we were able to establish humanized C. elegans as an animal model for HSP and use it to test the significance of five variants of unce …
Hereditary spastic paraplegia with recessive trait caused by mutation in KLC4 gene.
Bayrakli F, Poyrazoglu HG, Yuksel S, Yakicier C, Erguner B, Sagiroglu MS, Yuceturk B, Ozer B, Doganay S, Tanrikulu B, Seker A, Akbulut F, Ozen A, Per H, Kumandas S, Altuner Torun Y, Bayri Y, Sakar M, Dagcinar A, Ziyal I. Bayrakli F, et al. J Hum Genet. 2015 Dec;60(12):763-8. doi: 10.1038/jhg.2015.109. Epub 2015 Oct 1. J Hum Genet. 2015. PMID: 26423925 Clinical Trial.
Whole-exome sequencing revealed a homozygous mutation (c.853_871del19) in the gene coding the kinesin light chain 4 protein (KLC4). Meanwhile, the unaffected parents and two siblings were heterozygous and one sibling was homozygous wild type. The 19 bp deletion in exon 6 g …
Whole-exome sequencing revealed a homozygous mutation (c.853_871del19) in the gene coding the kinesin light chain 4 protein (KLC4). M …
Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network.
Baek JH, Yun HS, Kim JY, Lee J, Lee YJ, Lee CW, Song JY, Ahn J, Park JK, Kim JS, Lee KH, Kim EH, Hwang SG. Baek JH, et al. Cell Death Dis. 2020 May 26;11(5):398. doi: 10.1038/s41419-020-2592-z. Cell Death Dis. 2020. PMID: 32457423 Free PMC article.
In addition, KLC4 and CHEK2 expression levels showed negative correlation in lung tumor samples from patients, and KLC4 overexpression correlated negatively with survival. Our results indicate a novel link between the KLC4 and CHK2 pathways regulating DNA dam …
In addition, KLC4 and CHEK2 expression levels showed negative correlation in lung tumor samples from patients, and KLC4 overex …
Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx.
Baek JH, Lee J, Yun HS, Lee CW, Song JY, Um HD, Park JK, Park IC, Kim JS, Kim EH, Hwang SG. Baek JH, et al. Cell Death Dis. 2018 May 1;9(5):496. doi: 10.1038/s41419-018-0549-2. Cell Death Dis. 2018. PMID: 29717133 Free PMC article.
KLC4 was upregulated in human lung cancer cell lines. Moreover, in paired clinical specimens of lung cancer patients, KLC4 expression was significantly higher in tumor tissues than in paired adjacent normal tissues. ...Colony formation decreased as the radiation dos …
KLC4 was upregulated in human lung cancer cell lines. Moreover, in paired clinical specimens of lung cancer patients, KLC4 exp …
Radiotherapy diagnostic biomarkers in radioresistant human H460 lung cancer stem-like cells.
Yun HS, Baek JH, Yim JH, Um HD, Park JK, Song JY, Park IC, Kim JS, Lee SJ, Lee CW, Hwang SG. Yun HS, et al. Cancer Biol Ther. 2016;17(2):208-18. doi: 10.1080/15384047.2016.1139232. Cancer Biol Ther. 2016. PMID: 26901847 Free PMC article.
Using proteomic analyses, we identified 8 proteins that were up-regulated in RR-H460 CSC lines and therefore potentially involved in radioresistance and CSC-related biological processes. Notably, 4 of these-PAI-2, NOMO2, KLC4, and PLOD3-have not been previously linked to r …
Using proteomic analyses, we identified 8 proteins that were up-regulated in RR-H460 CSC lines and therefore potentially involved in radiore …
Identification of tumor antigens and immune subtypes in head and neck squamous cell carcinoma for mRNA vaccine development.
Chen Y, Jiang N, Chen M, Sui B, Liu X. Chen Y, et al. Front Cell Dev Biol. 2022 Nov 17;10:1064754. doi: 10.3389/fcell.2022.1064754. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36467412 Free PMC article.
Here, we analyzed alternative splicing and mutation of genes in TCGA-HNSCC samples and identified seven potential tumor antigens, including SREBF1, LUC7L3, LAMA5, PCGF3, HNRNPH1, KLC4, and OFD1, which were associated with nonsense-mediated mRNA decay factor expression, ove …
Here, we analyzed alternative splicing and mutation of genes in TCGA-HNSCC samples and identified seven potential tumor antigens, including …
13 results