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Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.

Wouters R, Michiels C, Sannerud R, Kleizen B, Dillen K, Vermeire W, Ayala AE, Demedts D, Schekman R, Annaert W. Wouters R, et al. Among authors: kleizen b. J Cell Biol. 2021 Sep 6;220(9):e201911104. doi: 10.1083/jcb.201911104. Epub 2021 Jul 22. J Cell Biol. 2021. PMID: 34292306 Free PMC article.

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Correcting CFTR folding defects by small-molecule correctors to cure cystic fibrosis.

Mijnders M, Kleizen B, Braakman I. Mijnders M, et al. Among authors: kleizen b. Curr Opin Pharmacol. 2017 Jun;34:83-90. doi: 10.1016/j.coph.2017.09.014. Epub 2017 Oct 18. Curr Opin Pharmacol. 2017. PMID: 29055231 Free article. Review.

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Co-Translational Folding of the First Transmembrane Domain of ABC-Transporter CFTR is Supported by Assembly with the First Cytosolic Domain.

Kleizen B, van Willigen M, Mijnders M, Peters F, Grudniewska M, Hillenaar T, Thomas A, Kooijman L, Peters KW, Frizzell R, van der Sluijs P, Braakman I. Kleizen B, et al. J Mol Biol. 2021 Jun 25;433(13):166955. doi: 10.1016/j.jmb.2021.166955. Epub 2021 Mar 24. J Mol Biol. 2021. PMID: 33771570 Free article.

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Protein folding and quality control in the endoplasmic reticulum.

Kleizen B, Braakman I. Kleizen B, et al. Curr Opin Cell Biol. 2004 Aug;16(4):343-9. doi: 10.1016/j.ceb.2004.06.012. Curr Opin Cell Biol. 2004. PMID: 15261665 Review.

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CFTR: New insights into structure and function and implications for modulation by small molecules.

Kleizen B, Hunt JF, Callebaut I, Hwang TC, Sermet-Gaudelus I, Hafkemeyer S, Sheppard DN. Kleizen B, et al. J Cyst Fibros. 2020 Mar;19 Suppl 1:S19-S24. doi: 10.1016/j.jcf.2019.10.021. Epub 2019 Nov 21. J Cyst Fibros. 2020. PMID: 31759907 Free article.

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Regulated trafficking of the CFTR chloride channel.

Kleizen B, Braakman I, de Jonge HR. Kleizen B, et al. Eur J Cell Biol. 2000 Aug;79(8):544-56. doi: 10.1078/0171-9335-00078. Eur J Cell Biol. 2000. PMID: 11001491 Review.

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Cell biology. A sweet send-off.

Kleizen B, Braakman I. Kleizen B, et al. Science. 2013 May 24;340(6135):930-1. doi: 10.1126/science.1239294. Science. 2013. PMID: 23704559 No abstract available.

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Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants.

van Willigen M, Vonk AM, Yeoh HY, Kruisselbrink E, Kleizen B, van der Ent CK, Egmond MR, de Jonge HR, Braakman I, Beekman JM, van der Sluijs P. van Willigen M, et al. Among authors: kleizen b. Life Sci Alliance. 2019 Jan 18;2(1):e201800172. doi: 10.26508/lsa.201800172. Print 2019 Feb. Life Sci Alliance. 2019. PMID: 30659068 Free PMC article.

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Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase.

McCaul N, Yeoh HY, van Zadelhoff G, Lodder N, Kleizen B, Braakman I. McCaul N, et al. Among authors: kleizen b. J Vis Exp. 2019 Feb 12;(144). doi: 10.3791/58952. J Vis Exp. 2019. PMID: 30829321

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Alteration of protein function by a silent polymorphism linked to tRNA abundance.

Kirchner S, Cai Z, Rauscher R, Kastelic N, Anding M, Czech A, Kleizen B, Ostedgaard LS, Braakman I, Sheppard DN, Ignatova Z. Kirchner S, et al. Among authors: kleizen b. PLoS Biol. 2017 May 16;15(5):e2000779. doi: 10.1371/journal.pbio.2000779. eCollection 2017 May. PLoS Biol. 2017. PMID: 28510592 Free PMC article.

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